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Illumina Body Map 2: averaged replicates

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Results for TBX2

Z-value: 1.48

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Transcription factors associated with TBX2

Gene Symbol Gene ID Gene Info
TBX2
ENSG00000121068.9 T-box transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX2hg19_v2_chr17_+_59477233_59477263-0.115.5e-01Click!

Activity profile of TBX2 motif

Sorted Z-values of TBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_219031709 3.74 ENST00000295683.2
CXCR1
chemokine (C-X-C motif) receptor 1
chrY_+_2709527 3.49 ENST00000250784.8
RPS4Y1
ribosomal protein S4, Y-linked 1
chrY_+_2709906 3.18 ENST00000430575.1
RPS4Y1
ribosomal protein S4, Y-linked 1
chr19_-_51875894 2.89 ENST00000600427.1
ENST00000595217.1
ENST00000221978.5
NKG7
natural killer cell group 7 sequence
chr5_+_54320078 2.69 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr19_+_859425 2.68 ENST00000327726.6
CFD
complement factor D (adipsin)
chr6_+_131894284 2.37 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr19_+_859654 2.37 ENST00000592860.1
CFD
complement factor D (adipsin)
chr19_-_51875523 2.31 ENST00000593572.1
ENST00000595157.1
NKG7
natural killer cell group 7 sequence
chr3_-_44465475 1.97 ENST00000416124.1
LINC00694
long intergenic non-protein coding RNA 694
chr2_+_171571827 1.93 ENST00000375281.3
SP5
Sp5 transcription factor
chr15_-_22448819 1.84 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr12_-_7848364 1.78 ENST00000329913.3
GDF3
growth differentiation factor 3
chr6_-_6225026 1.74 ENST00000445223.1
F13A1
coagulation factor XIII, A1 polypeptide
chr3_+_52811596 1.71 ENST00000542827.1
ENST00000273283.2
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr7_-_142181009 1.61 ENST00000390368.2
TRBV6-5
T cell receptor beta variable 6-5
chr1_+_203444887 1.57 ENST00000343110.2
PRELP
proline/arginine-rich end leucine-rich repeat protein
chr1_+_32716857 1.53 ENST00000482949.1
ENST00000495610.2
LCK
lymphocyte-specific protein tyrosine kinase
chr12_-_91348949 1.53 ENST00000358859.2
CCER1
coiled-coil glutamate-rich protein 1
chr7_+_80253387 1.52 ENST00000438020.1
CD36
CD36 molecule (thrombospondin receptor)
chr1_+_32716840 1.51 ENST00000336890.5
LCK
lymphocyte-specific protein tyrosine kinase
chr8_-_99955042 1.48 ENST00000519420.1
STK3
serine/threonine kinase 3
chr1_-_150780757 1.48 ENST00000271651.3
CTSK
cathepsin K
chr20_-_1538319 1.47 ENST00000381621.1
SIRPD
signal-regulatory protein delta
chr7_-_142240014 1.46 ENST00000390363.2
TRBV9
T cell receptor beta variable 9
chrX_-_70329118 1.44 ENST00000374188.3
IL2RG
interleukin 2 receptor, gamma
chr3_+_148447887 1.41 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr6_+_391739 1.41 ENST00000380956.4
IRF4
interferon regulatory factor 4
chr21_+_30502806 1.40 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr7_-_142120321 1.37 ENST00000390377.1
TRBV7-7
T cell receptor beta variable 7-7
chr15_-_35088340 1.34 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr22_+_40441456 1.33 ENST00000402203.1
TNRC6B
trinucleotide repeat containing 6B
chr4_+_124317940 1.32 ENST00000505319.1
ENST00000339241.1
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr10_-_99531709 1.31 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr2_+_7865923 1.25 ENST00000417930.1
AC092580.4
AC092580.4
chr21_+_30503282 1.24 ENST00000399925.1
MAP3K7CL
MAP3K7 C-terminal like
chr14_+_21236586 1.22 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr7_-_142224280 1.20 ENST00000390367.3
TRBV11-1
T cell receptor beta variable 11-1
chr1_+_154975110 1.20 ENST00000535420.1
ENST00000368426.3
ZBTB7B
zinc finger and BTB domain containing 7B
chr10_+_114135952 1.19 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_39108643 1.18 ENST00000396857.2
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr1_+_20915409 1.17 ENST00000375071.3
CDA
cytidine deaminase
chr12_+_58148842 1.17 ENST00000266643.5
MARCH9
membrane-associated ring finger (C3HC4) 9
chrX_+_123480194 1.16 ENST00000371139.4
SH2D1A
SH2 domain containing 1A
chr17_-_46657473 1.15 ENST00000332503.5
HOXB4
homeobox B4
chr19_+_55235969 1.14 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000291860.1
ENST00000396284.2
KIR3DL1
KIR3DL3
KIR2DL4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
chr16_+_12059050 1.13 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr19_-_39108568 1.13 ENST00000586296.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr4_+_155484155 1.13 ENST00000509493.1
FGB
fibrinogen beta chain
chr19_-_39108552 1.12 ENST00000591517.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr1_-_25256368 1.11 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr4_+_155484103 1.10 ENST00000302068.4
FGB
fibrinogen beta chain
chrX_+_99899180 1.09 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr16_-_79634595 1.09 ENST00000326043.4
ENST00000393350.1
MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr2_-_217724767 1.08 ENST00000236979.2
TNP1
transition protein 1 (during histone to protamine replacement)
chr5_+_35856951 1.07 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr10_+_114135004 1.05 ENST00000393081.1
ACSL5
acyl-CoA synthetase long-chain family member 5
chr9_-_117150303 1.03 ENST00000312033.3
AKNA
AT-hook transcription factor
chr7_-_18067478 1.01 ENST00000506618.2
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1
chr14_-_21058982 1.00 ENST00000556526.1
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr7_-_27135591 1.00 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr1_-_207095212 0.99 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr2_+_102758751 0.99 ENST00000442590.1
IL1R1
interleukin 1 receptor, type I
chr16_+_12058961 0.99 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_+_52431016 0.98 ENST00000553200.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr12_+_93965609 0.98 ENST00000549887.1
ENST00000551556.1
SOCS2
suppressor of cytokine signaling 2
chr19_+_52264104 0.97 ENST00000340023.6
FPR2
formyl peptide receptor 2
chr16_+_31271274 0.97 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr1_-_1142067 0.96 ENST00000379268.2
TNFRSF18
tumor necrosis factor receptor superfamily, member 18
chr8_-_101724989 0.96 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr17_-_7081435 0.96 ENST00000380920.4
ASGR1
asialoglycoprotein receptor 1
chr19_-_10213335 0.96 ENST00000592641.1
ENST00000253109.4
ANGPTL6
angiopoietin-like 6
chr15_-_55581954 0.95 ENST00000336787.1
RAB27A
RAB27A, member RAS oncogene family
chr1_+_167599532 0.95 ENST00000537350.1
RCSD1
RCSD domain containing 1
chr1_-_22263790 0.93 ENST00000374695.3
HSPG2
heparan sulfate proteoglycan 2
chr7_-_36764062 0.92 ENST00000435386.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr12_+_32112340 0.92 ENST00000540924.1
ENST00000312561.4
KIAA1551
KIAA1551
chrX_+_70503037 0.92 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr12_+_57388230 0.91 ENST00000300098.1
GPR182
G protein-coupled receptor 182
chr1_+_154975258 0.91 ENST00000417934.2
ZBTB7B
zinc finger and BTB domain containing 7B
chr5_+_38445641 0.89 ENST00000397210.3
ENST00000506135.1
ENST00000508131.1
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr5_+_137514403 0.89 ENST00000513276.1
KIF20A
kinesin family member 20A
chr15_+_94774767 0.89 ENST00000543482.1
MCTP2
multiple C2 domains, transmembrane 2
chr12_+_47617284 0.89 ENST00000549630.1
ENST00000551777.1
PCED1B
PC-esterase domain containing 1B
chr2_+_234875252 0.88 ENST00000456930.1
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr7_-_100239132 0.88 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr14_+_103058948 0.87 ENST00000262241.6
RCOR1
REST corepressor 1
chr7_-_99381884 0.86 ENST00000336411.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr19_-_6670128 0.86 ENST00000245912.3
TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr10_-_131762105 0.86 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr14_-_24664540 0.86 ENST00000530563.1
ENST00000528895.1
ENST00000528669.1
ENST00000532632.1
TM9SF1
transmembrane 9 superfamily member 1
chr11_-_414948 0.85 ENST00000530494.1
ENST00000528209.1
ENST00000431843.2
ENST00000528058.1
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_+_101702417 0.85 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr12_+_11905413 0.85 ENST00000545027.1
ETV6
ets variant 6
chr10_+_95256356 0.84 ENST00000371485.3
CEP55
centrosomal protein 55kDa
chr19_-_17958771 0.84 ENST00000534444.1
JAK3
Janus kinase 3
chr11_-_28129656 0.84 ENST00000263181.6
KIF18A
kinesin family member 18A
chr19_-_45748628 0.84 ENST00000590022.1
AC006126.4
AC006126.4
chr5_-_137610300 0.83 ENST00000274721.3
GFRA3
GDNF family receptor alpha 3
chr12_-_49318715 0.82 ENST00000444214.2
FKBP11
FK506 binding protein 11, 19 kDa
chr20_-_44516256 0.81 ENST00000372519.3
SPATA25
spermatogenesis associated 25
chr12_+_52430894 0.81 ENST00000546842.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr7_-_36764004 0.80 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr16_-_67450325 0.80 ENST00000348579.2
ZDHHC1
zinc finger, DHHC-type containing 1
chr14_+_21249200 0.79 ENST00000304677.2
RNASE6
ribonuclease, RNase A family, k6
chr12_+_65672423 0.79 ENST00000355192.3
ENST00000308259.5
ENST00000540804.1
ENST00000535664.1
ENST00000541189.1
MSRB3
methionine sulfoxide reductase B3
chr19_+_55281260 0.79 ENST00000336077.6
ENST00000291633.7
KIR2DL1
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
chr12_+_54379569 0.78 ENST00000513209.1
RP11-834C11.12
RP11-834C11.12
chr11_+_71846764 0.77 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr5_-_137610254 0.77 ENST00000378362.3
GFRA3
GDNF family receptor alpha 3
chr19_+_50529212 0.77 ENST00000270617.3
ENST00000445728.3
ENST00000601364.1
ZNF473
zinc finger protein 473
chr11_-_66112555 0.77 ENST00000425825.2
ENST00000359957.3
BRMS1
breast cancer metastasis suppressor 1
chr14_+_95027772 0.76 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr12_+_65672702 0.76 ENST00000538045.1
ENST00000535239.1
MSRB3
methionine sulfoxide reductase B3
chr4_+_141445333 0.76 ENST00000507667.1
ELMOD2
ELMO/CED-12 domain containing 2
chr1_+_178482212 0.76 ENST00000319416.2
ENST00000258298.2
ENST00000367643.3
ENST00000367642.3
TEX35
testis expressed 35
chr11_-_615570 0.75 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr6_-_84937314 0.75 ENST00000257766.4
ENST00000403245.3
KIAA1009
KIAA1009
chr11_+_120081475 0.75 ENST00000328965.4
OAF
OAF homolog (Drosophila)
chr19_-_40772221 0.75 ENST00000441941.2
ENST00000580747.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr1_+_172628154 0.75 ENST00000340030.3
ENST00000367721.2
FASLG
Fas ligand (TNF superfamily, member 6)
chr19_+_50528971 0.74 ENST00000598809.1
ENST00000595661.1
ENST00000391821.2
ZNF473
zinc finger protein 473
chr11_+_1940786 0.73 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
TNNT3
troponin T type 3 (skeletal, fast)
chr6_-_26108355 0.73 ENST00000338379.4
HIST1H1T
histone cluster 1, H1t
chr12_+_57853918 0.73 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1
GLI family zinc finger 1
chr1_+_206858232 0.72 ENST00000294981.4
MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2
chr1_-_1141927 0.71 ENST00000328596.6
ENST00000379265.5
TNFRSF18
tumor necrosis factor receptor superfamily, member 18
chr9_-_134585221 0.70 ENST00000372190.3
ENST00000427994.1
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr20_+_48884002 0.70 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr16_+_27413483 0.69 ENST00000337929.3
ENST00000564089.1
IL21R
interleukin 21 receptor
chr19_-_44174330 0.69 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr4_+_55096010 0.69 ENST00000503856.1
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr7_-_36764142 0.69 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr20_+_59654146 0.69 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr2_+_53994927 0.68 ENST00000295304.4
CHAC2
ChaC, cation transport regulator homolog 2 (E. coli)
chr2_+_28718921 0.68 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1
phospholipase B1
chr9_+_214842 0.68 ENST00000453981.1
ENST00000432829.2
DOCK8
dedicator of cytokinesis 8
chr22_+_35776828 0.67 ENST00000216117.8
HMOX1
heme oxygenase (decycling) 1
chr3_-_187694195 0.67 ENST00000446091.1
RP11-132N15.3
RP11-132N15.3
chr19_-_13213662 0.67 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr17_-_7590745 0.66 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
TP53
tumor protein p53
chr12_+_75874984 0.66 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr2_+_102758210 0.65 ENST00000450319.1
IL1R1
interleukin 1 receptor, type I
chr4_+_55096489 0.65 ENST00000504461.1
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr22_+_24823517 0.65 ENST00000496258.1
ENST00000337539.7
ADORA2A
adenosine A2a receptor
chr9_-_96717654 0.65 ENST00000253968.6
BARX1
BARX homeobox 1
chr22_+_22988816 0.65 ENST00000480559.1
ENST00000448514.1
GGTLC2
gamma-glutamyltransferase light chain 2
chr2_+_90248739 0.65 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr2_+_102758271 0.64 ENST00000428279.1
IL1R1
interleukin 1 receptor, type I
chr4_+_105828537 0.64 ENST00000515649.1
RP11-556I14.1
RP11-556I14.1
chr1_+_182758900 0.64 ENST00000367555.1
ENST00000367554.3
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr6_-_31619697 0.64 ENST00000434444.1
BAG6
BCL2-associated athanogene 6
chr6_-_31620149 0.64 ENST00000435080.1
ENST00000375976.4
ENST00000441054.1
BAG6
BCL2-associated athanogene 6
chr3_-_183967296 0.64 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr12_-_56121580 0.64 ENST00000550776.1
CD63
CD63 molecule
chr8_+_24241969 0.63 ENST00000522298.1
ADAMDEC1
ADAM-like, decysin 1
chr20_-_23433494 0.63 ENST00000377007.3
CST11
cystatin 11
chr9_-_71161505 0.63 ENST00000446290.1
RP11-274B18.2
RP11-274B18.2
chr6_-_130536774 0.63 ENST00000532763.1
SAMD3
sterile alpha motif domain containing 3
chr10_-_74114714 0.62 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr1_-_67519782 0.62 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr1_+_92417716 0.61 ENST00000402388.1
BRDT
bromodomain, testis-specific
chr12_-_15104040 0.61 ENST00000541644.1
ENST00000545895.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_-_119693745 0.61 ENST00000371323.2
CUL4B
cullin 4B
chr5_-_44388899 0.61 ENST00000264664.4
FGF10
fibroblast growth factor 10
chr3_-_119379427 0.61 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
POPDC2
popeye domain containing 2
chrX_-_53461288 0.60 ENST00000375298.4
ENST00000375304.5
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr19_+_18529674 0.60 ENST00000597724.2
SSBP4
single stranded DNA binding protein 4
chr17_-_43502987 0.60 ENST00000376922.2
ARHGAP27
Rho GTPase activating protein 27
chr6_-_160166218 0.59 ENST00000537657.1
SOD2
superoxide dismutase 2, mitochondrial
chr19_-_46526304 0.59 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr5_+_110407390 0.59 ENST00000344895.3
TSLP
thymic stromal lymphopoietin
chr20_+_816695 0.59 ENST00000246100.3
FAM110A
family with sequence similarity 110, member A
chr11_-_15643937 0.59 ENST00000533082.1
RP11-531H8.2
RP11-531H8.2
chr12_-_56122426 0.59 ENST00000551173.1
CD63
CD63 molecule
chr2_+_29033682 0.59 ENST00000379579.4
ENST00000334056.5
ENST00000449210.1
SPDYA
speedy/RINGO cell cycle regulator family member A
chr19_-_55458860 0.59 ENST00000592784.1
ENST00000448121.2
ENST00000340844.2
NLRP7
NLR family, pyrin domain containing 7
chr10_-_97175444 0.59 ENST00000486141.2
SORBS1
sorbin and SH3 domain containing 1
chr12_-_53614043 0.59 ENST00000338561.5
RARG
retinoic acid receptor, gamma
chr16_-_11367452 0.58 ENST00000327157.2
PRM3
protamine 3
chr19_-_50529193 0.58 ENST00000596445.1
ENST00000599538.1
VRK3
vaccinia related kinase 3
chr12_-_46385811 0.58 ENST00000419565.2
SCAF11
SR-related CTD-associated factor 11
chr12_+_21525818 0.58 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
IAPP
islet amyloid polypeptide
chr8_+_56014949 0.58 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr22_-_31328881 0.58 ENST00000445980.1
MORC2
MORC family CW-type zinc finger 2
chr12_-_18890940 0.57 ENST00000543242.1
ENST00000539072.1
ENST00000541966.1
ENST00000266505.7
ENST00000447925.2
ENST00000435379.1
PLCZ1
phospholipase C, zeta 1
chr21_-_35884573 0.57 ENST00000399286.2
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr15_-_37783009 0.57 ENST00000561054.1
RP11-720L8.1
RP11-720L8.1
chr3_-_39196049 0.57 ENST00000514182.1
CSRNP1
cysteine-serine-rich nuclear protein 1
chr20_+_44509857 0.56 ENST00000372523.1
ENST00000372520.1
ZSWIM1
zinc finger, SWIM-type containing 1
chr19_-_17958832 0.56 ENST00000458235.1
JAK3
Janus kinase 3
chr12_-_57522813 0.56 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_-_44972476 0.56 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr19_+_50832943 0.55 ENST00000542413.1
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr14_-_51411194 0.55 ENST00000544180.2
PYGL
phosphorylase, glycogen, liver
chr7_+_99036996 0.54 ENST00000441580.1
ENST00000412686.1
CPSF4
cleavage and polyadenylation specific factor 4, 30kDa
chr19_+_55897699 0.54 ENST00000558131.1
ENST00000558752.1
ENST00000458349.2
RPL28
ribosomal protein L28
chr8_-_134584092 0.54 ENST00000522652.1
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_6260896 0.54 ENST00000497965.1
RPL22
ribosomal protein L22
chr2_-_209118974 0.54 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.7 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.6 2.8 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.5 2.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.5 1.4 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.5 1.4 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
0.5 2.8 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.4 1.4 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.3 1.3 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.3 1.9 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 1.6 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.3 0.9 GO:0019858 cytosine metabolic process(GO:0019858)
0.3 0.8 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.3 1.1 GO:0060032 notochord regression(GO:0060032)
0.3 0.3 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.3 2.6 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.2 3.2 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.2 1.6 GO:0070384 Harderian gland development(GO:0070384)
0.2 0.7 GO:0061485 memory T cell proliferation(GO:0061485)
0.2 1.3 GO:0090131 mesenchyme migration(GO:0090131)
0.2 0.7 GO:0090108 positive regulation of high-density lipoprotein particle assembly(GO:0090108) positive regulation of secretion of lysosomal enzymes(GO:0090340)
0.2 0.9 GO:0009822 alkaloid catabolic process(GO:0009822)
0.2 1.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.2 0.6 GO:0051039 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.2 5.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.2 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.2 0.6 GO:0032824 negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.2 1.8 GO:0048859 formation of anatomical boundary(GO:0048859)
0.2 2.0 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 1.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.2 1.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.2 2.0 GO:0035771 interleukin-4-mediated signaling pathway(GO:0035771)
0.2 0.5 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 0.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2 0.9 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.2 0.7 GO:0006788 heme oxidation(GO:0006788) negative regulation of mast cell cytokine production(GO:0032764)
0.2 0.7 GO:0051097 negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.2 2.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.1 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.2 0.5 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.1 1.5 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.9 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 1.1 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.1 1.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.0 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 1.5 GO:0070543 response to linoleic acid(GO:0070543)
0.1 1.8 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 3.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 1.1 GO:0048539 bone marrow development(GO:0048539)
0.1 0.8 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.6 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.9 GO:0050955 thermoception(GO:0050955)
0.1 0.7 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.5 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.9 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 0.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 1.6 GO:0030091 protein repair(GO:0030091)
0.1 0.6 GO:0003069 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1 1.0 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.6 GO:0007343 egg activation(GO:0007343)
0.1 0.3 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.8 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.1 0.9 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 3.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.5 GO:0046778 modification by virus of host mRNA processing(GO:0046778)
0.1 0.5 GO:0032571 response to vitamin K(GO:0032571)
0.1 0.8 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.3 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.1 0.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 1.5 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.7 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 2.3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 1.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915) positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.4 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.7 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.6 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.5 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.4 GO:0001757 somite specification(GO:0001757)
0.1 0.3 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.2 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.7 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 1.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 1.6 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.2 GO:1903464 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) negative regulation of mitotic cell cycle DNA replication(GO:1903464) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.6 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 0.4 GO:0010847 regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213)
0.1 0.3 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.1 0.8 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 0.5 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 0.2 GO:0061580 colon epithelial cell migration(GO:0061580)
0.1 0.3 GO:2001162 regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.1 0.4 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 1.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 1.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.8 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.8 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.3 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.1 1.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1 0.1 GO:0060268 negative regulation of respiratory burst(GO:0060268)
0.1 0.6 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 1.0 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 0.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.6 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.1 0.5 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.1 0.3 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1 0.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.3 GO:0001519 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.1 0.8 GO:0015884 folic acid transport(GO:0015884)
0.1 1.0 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 2.0 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 2.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 0.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.3 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.1 0.4 GO:1901297 arterial endothelial cell fate commitment(GO:0060844) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 8.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.7 GO:0001955 blood vessel maturation(GO:0001955)
0.1 0.9 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.4 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 1.7 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.2 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.7 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.4 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 1.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.2 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.0 0.4 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 1.3 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.5 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.3 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.6 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.5 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.0 3.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.4 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.7 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 1.4 GO:0048485 sympathetic nervous system development(GO:0048485)
0.0 0.2 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.9 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.3 GO:1902846 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.2 GO:2000323 circadian regulation of translation(GO:0097167) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.7 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.4 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.1 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.6 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.1 GO:0097017 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) renal protein absorption(GO:0097017) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 2.2 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 1.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.4 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.4 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.4 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0 0.6 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.9 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 1.1 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.2 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0 0.5 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.7 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.6 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.4 GO:0033599 regulation of mammary gland epithelial cell proliferation(GO:0033599)
0.0 0.3 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.9 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.9 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.5 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 1.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.0 0.6 GO:0016180 snRNA processing(GO:0016180)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.6 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.0 0.5 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.4 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.7 GO:0048536 spleen development(GO:0048536)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
0.0 0.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.2 GO:2000507 cap-dependent translational initiation(GO:0002191) positive regulation of energy homeostasis(GO:2000507)
0.0 0.5 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.5 GO:0097186 amelogenesis(GO:0097186)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.4 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.3 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.6 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 0.3 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847) negative regulation of osteoclast development(GO:2001205)
0.0 0.4 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.6 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.2 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.4 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.1 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.0 0.3 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0042643 actomyosin, actin portion(GO:0042643)
0.2 3.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.2 2.6 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 1.5 GO:0036021 endolysosome lumen(GO:0036021)
0.2 0.8 GO:0097183 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.2 2.2 GO:0005577 fibrinogen complex(GO:0005577)
0.2 2.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.1 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 1.0 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.1 0.3 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 7.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.0 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.6 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.9 GO:0042382 paraspeckles(GO:0042382)
0.1 0.2 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.1 0.5 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.1 0.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.1 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.7 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.5 GO:0000125 PCAF complex(GO:0000125)
0.0 0.8 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 5.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.8 GO:0090543 Flemming body(GO:0090543)
0.0 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.4 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.9 GO:0005861 troponin complex(GO:0005861)
0.0 0.5 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 1.6 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 1.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.8 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 3.1 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 9.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.1 GO:0015030 Cajal body(GO:0015030)
0.0 0.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.5 GO:0097542 ciliary tip(GO:0097542)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 3.6 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.1 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.8 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 1.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 1.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.9 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.8 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.0 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0044754 autolysosome(GO:0044754)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.6 3.7 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.6 2.4 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.5 1.4 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.4 2.8 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.3 3.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 1.3 GO:0005018 platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.2 1.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 0.7 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.2 0.9 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 0.9 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.2 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 1.1 GO:0030109 HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.2 1.5 GO:0005124 N-formyl peptide receptor activity(GO:0004982) scavenger receptor binding(GO:0005124)
0.2 0.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 0.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.2 0.7 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.2 0.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 1.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.7 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 0.5 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.2 1.1 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.2 0.6 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.6 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.4 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.1 0.4 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 1.0 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 3.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.5 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
0.1 0.7 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 1.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.4 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 2.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.5 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 1.0 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.6 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.5 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.1 0.5 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 0.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.6 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1 0.7 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.1 0.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.3 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 2.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.5 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.3 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 0.5 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.1 0.3 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.1 1.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.3 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.3 GO:0008518 reduced folate carrier activity(GO:0008518)
0.1 6.7 GO:0019843 rRNA binding(GO:0019843)
0.1 1.0 GO:0001851 complement component C3b binding(GO:0001851)
0.1 1.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 1.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.2 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 0.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.4 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.1 0.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 2.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.1 0.5 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.3 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.1 1.0 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.5 GO:0032190 acrosin binding(GO:0032190)
0.1 0.5 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.7 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 1.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0031433 telethonin binding(GO:0031433)
0.0 1.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.6 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.8 GO:0005542 folic acid binding(GO:0005542)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.9 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 1.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 1.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 1.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.5 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.3 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 1.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.1 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 2.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.8 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.7 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 2.6 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 0.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.7 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.2 GO:0051087 chaperone binding(GO:0051087)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.9 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 2.5 GO:0004519 endonuclease activity(GO:0004519)
0.0 9.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0003924 GTPase activity(GO:0003924)
0.0 0.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 4.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.3 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 3.3 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 3.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 5.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 4.5 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 2.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 3.4 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 3.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 4.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.8 PID AURORA B PATHWAY Aurora B signaling
0.0 1.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 3.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID FOXO PATHWAY FoxO family signaling
0.0 5.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 5.0 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 3.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 2.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 4.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.5 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 6.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.8 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 2.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.7 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.2 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 1.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.6 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 2.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.2 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.7 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 1.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 3.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.3 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 1.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 2.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 0.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.5 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 2.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.7 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 2.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 2.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.0 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression