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Illumina Body Map 2: averaged replicates
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Results for TBX3
Z-value: 1.71
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Transcription factors associated with TBX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX3 | hg19_v2_chr12_-_115121962_115121987 | -0.08 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_156824840 Show fit | 4.44 |
ENST00000536354.2
|
tryptophan 2,3-dioxygenase |
|
| chr6_-_52668605 Show fit | 3.83 |
ENST00000334575.5
|
glutathione S-transferase alpha 1 |
|
| chr20_+_56725952 Show fit | 3.73 |
ENST00000371168.3
|
chromosome 20 open reading frame 85 |
|
| chr13_-_46679144 Show fit | 3.43 |
ENST00000181383.4
|
carboxypeptidase B2 (plasma) |
|
| chr22_+_22749343 Show fit | 3.26 |
ENST00000390298.2
|
immunoglobulin lambda variable 7-43 |
|
| chr2_-_89310012 Show fit | 3.18 |
ENST00000493819.1
|
immunoglobulin kappa variable 1-9 |
|
| chr5_+_54320078 Show fit | 3.00 |
ENST00000231009.2
|
granzyme K (granzyme 3; tryptase II) |
|
| chr14_-_106642049 Show fit | 2.98 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
|
| chr3_+_149192475 Show fit | 2.93 |
ENST00000465758.1
|
transmembrane 4 L six family member 4 |
|
| chr22_+_23237555 Show fit | 2.90 |
ENST00000390321.2
|
immunoglobulin lambda constant 1 (Mcg marker) |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 10.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 8.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 5.6 | GO:1901687 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.0 | 5.3 | GO:0042246 | tissue regeneration(GO:0042246) |
| 1.1 | 4.4 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.3 | 4.3 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.4 | 3.5 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.9 | 3.4 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.0 | 3.2 | GO:0001958 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 10.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 4.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 4.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 4.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 4.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 3.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.8 | 3.2 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 3.2 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.7 | 2.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 10.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 10.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 4.4 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.0 | 4.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 3.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 3.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 3.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 3.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.8 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.0 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.8 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 0.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.3 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 4.4 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 4.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 3.5 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 3.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.7 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 2.0 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 1.8 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |