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Illumina Body Map 2: averaged replicates
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Results for TBX5
Z-value: 1.50
Motif logo
Transcription factors associated with TBX5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TBX5
|
ENSG00000089225.15 | T-box transcription factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX5 | hg19_v2_chr12_-_114841703_114841726 | 0.25 | 1.7e-01 | Click! |
Activity profile of TBX5 motif
Sorted Z-values of TBX5 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_39108643 | 2.93 |
ENST00000396857.2
|
MAP4K1
|
mitogen-activated protein kinase kinase kinase kinase 1 |
| chr14_+_98602380 | 2.78 |
ENST00000557072.1
|
RP11-61O1.2
|
RP11-61O1.2 |
| chr19_-_39108568 | 2.66 |
ENST00000586296.1
|
MAP4K1
|
mitogen-activated protein kinase kinase kinase kinase 1 |
| chr19_-_39108552 | 2.65 |
ENST00000591517.1
|
MAP4K1
|
mitogen-activated protein kinase kinase kinase kinase 1 |
| chr2_+_7865923 | 2.32 |
ENST00000417930.1
|
AC092580.4
|
AC092580.4 |
| chr7_+_80231466 | 1.90 |
ENST00000309881.7
ENST00000534394.1 |
CD36
|
CD36 molecule (thrombospondin receptor) |
| chr19_-_45826125 | 1.88 |
ENST00000221476.3
|
CKM
|
creatine kinase, muscle |
| chr11_+_1940786 | 1.84 |
ENST00000278317.6
ENST00000381561.4 ENST00000381548.3 ENST00000360603.3 ENST00000381549.3 |
TNNT3
|
troponin T type 3 (skeletal, fast) |
| chr11_-_107590383 | 1.81 |
ENST00000525934.1
ENST00000531293.1 |
SLN
|
sarcolipin |
| chr5_+_82767583 | 1.74 |
ENST00000512590.2
ENST00000513960.1 ENST00000513984.1 ENST00000502527.2 |
VCAN
|
versican |
| chr6_-_6225026 | 1.73 |
ENST00000445223.1
|
F13A1
|
coagulation factor XIII, A1 polypeptide |
| chr21_+_30503282 | 1.73 |
ENST00000399925.1
|
MAP3K7CL
|
MAP3K7 C-terminal like |
| chr20_+_816695 | 1.72 |
ENST00000246100.3
|
FAM110A
|
family with sequence similarity 110, member A |
| chr12_+_81101277 | 1.72 |
ENST00000228641.3
|
MYF6
|
myogenic factor 6 (herculin) |
| chr1_-_169680745 | 1.71 |
ENST00000236147.4
|
SELL
|
selectin L |
| chr7_-_142181009 | 1.66 |
ENST00000390368.2
|
TRBV6-5
|
T cell receptor beta variable 6-5 |
| chr19_-_42721819 | 1.66 |
ENST00000336034.4
ENST00000598200.1 ENST00000598727.1 ENST00000596251.1 |
DEDD2
|
death effector domain containing 2 |
| chrY_+_15016725 | 1.64 |
ENST00000336079.3
|
DDX3Y
|
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| chr11_+_1860200 | 1.63 |
ENST00000381911.1
|
TNNI2
|
troponin I type 2 (skeletal, fast) |
| chr11_+_1940925 | 1.62 |
ENST00000453458.1
ENST00000381557.2 ENST00000381589.3 ENST00000381579.3 ENST00000381563.4 ENST00000344578.4 |
TNNT3
|
troponin T type 3 (skeletal, fast) |
| chr14_+_75746781 | 1.59 |
ENST00000555347.1
|
FOS
|
FBJ murine osteosarcoma viral oncogene homolog |
| chr21_+_30502806 | 1.55 |
ENST00000399928.1
ENST00000399926.1 |
MAP3K7CL
|
MAP3K7 C-terminal like |
| chr11_+_35198118 | 1.52 |
ENST00000525211.1
ENST00000526000.1 ENST00000279452.6 ENST00000527889.1 |
CD44
|
CD44 molecule (Indian blood group) |
| chr5_+_54320078 | 1.52 |
ENST00000231009.2
|
GZMK
|
granzyme K (granzyme 3; tryptase II) |
| chr3_-_39234074 | 1.47 |
ENST00000340369.3
ENST00000421646.1 ENST00000396251.1 |
XIRP1
|
xin actin-binding repeat containing 1 |
| chr5_-_100238918 | 1.45 |
ENST00000451528.2
|
ST8SIA4
|
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
| chr20_+_30407105 | 1.44 |
ENST00000375994.2
|
MYLK2
|
myosin light chain kinase 2 |
| chr20_+_30407151 | 1.42 |
ENST00000375985.4
|
MYLK2
|
myosin light chain kinase 2 |
| chrX_-_70329118 | 1.39 |
ENST00000374188.3
|
IL2RG
|
interleukin 2 receptor, gamma |
| chr1_-_11042094 | 1.36 |
ENST00000377004.4
ENST00000377008.4 |
C1orf127
|
chromosome 1 open reading frame 127 |
| chr5_+_82767487 | 1.33 |
ENST00000343200.5
ENST00000342785.4 |
VCAN
|
versican |
| chr6_-_45983549 | 1.32 |
ENST00000544153.1
|
CLIC5
|
chloride intracellular channel 5 |
| chr18_+_32073253 | 1.31 |
ENST00000283365.9
ENST00000596745.1 ENST00000315456.6 |
DTNA
|
dystrobrevin, alpha |
| chrY_+_15016013 | 1.30 |
ENST00000360160.4
ENST00000454054.1 |
DDX3Y
|
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| chr1_-_157670647 | 1.30 |
ENST00000368184.3
|
FCRL3
|
Fc receptor-like 3 |
| chr5_+_82767284 | 1.28 |
ENST00000265077.3
|
VCAN
|
versican |
| chr14_+_22748980 | 1.27 |
ENST00000390465.2
|
TRAV38-2DV8
|
T cell receptor alpha variable 38-2/delta variable 8 |
| chr14_-_23904861 | 1.27 |
ENST00000355349.3
|
MYH7
|
myosin, heavy chain 7, cardiac muscle, beta |
| chr17_+_68164752 | 1.27 |
ENST00000535240.1
|
KCNJ2
|
potassium inwardly-rectifying channel, subfamily J, member 2 |
| chr2_-_152589670 | 1.26 |
ENST00000604864.1
ENST00000603639.1 |
NEB
|
nebulin |
| chr5_-_100238956 | 1.26 |
ENST00000231461.5
|
ST8SIA4
|
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
| chr10_-_125853200 | 1.25 |
ENST00000421115.1
|
CHST15
|
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 |
| chr19_-_42636543 | 1.24 |
ENST00000528894.4
ENST00000560804.2 ENST00000560558.1 ENST00000560398.1 ENST00000526816.2 |
POU2F2
|
POU class 2 homeobox 2 |
| chr1_+_101702417 | 1.24 |
ENST00000305352.6
|
S1PR1
|
sphingosine-1-phosphate receptor 1 |
| chr1_-_157670528 | 1.23 |
ENST00000368186.5
ENST00000496769.1 |
FCRL3
|
Fc receptor-like 3 |
| chr12_+_65672702 | 1.22 |
ENST00000538045.1
ENST00000535239.1 |
MSRB3
|
methionine sulfoxide reductase B3 |
| chr22_-_51016433 | 1.22 |
ENST00000405237.3
|
CPT1B
|
carnitine palmitoyltransferase 1B (muscle) |
| chr19_+_7741968 | 1.22 |
ENST00000597445.1
|
C19orf59
|
chromosome 19 open reading frame 59 |
| chr17_-_3819751 | 1.20 |
ENST00000225538.3
|
P2RX1
|
purinergic receptor P2X, ligand-gated ion channel, 1 |
| chr18_+_32073839 | 1.20 |
ENST00000590412.1
|
DTNA
|
dystrobrevin, alpha |
| chr3_-_42744130 | 1.19 |
ENST00000417472.1
ENST00000442469.1 |
HHATL
|
hedgehog acyltransferase-like |
| chr1_-_27961720 | 1.19 |
ENST00000545953.1
ENST00000374005.3 |
FGR
|
feline Gardner-Rasheed sarcoma viral oncogene homolog |
| chr1_-_25256368 | 1.18 |
ENST00000308873.6
|
RUNX3
|
runt-related transcription factor 3 |
| chr10_-_99531709 | 1.18 |
ENST00000266066.3
|
SFRP5
|
secreted frizzled-related protein 5 |
| chr19_+_7733929 | 1.16 |
ENST00000221515.2
|
RETN
|
resistin |
| chr1_-_153518270 | 1.16 |
ENST00000354332.4
ENST00000368716.4 |
S100A4
|
S100 calcium binding protein A4 |
| chr22_-_31688431 | 1.14 |
ENST00000402249.3
ENST00000443175.1 ENST00000215912.5 ENST00000441972.1 |
PIK3IP1
|
phosphoinositide-3-kinase interacting protein 1 |
| chr6_-_45983581 | 1.14 |
ENST00000339561.6
|
CLIC5
|
chloride intracellular channel 5 |
| chr7_-_142120321 | 1.14 |
ENST00000390377.1
|
TRBV7-7
|
T cell receptor beta variable 7-7 |
| chr1_+_228395755 | 1.13 |
ENST00000284548.11
ENST00000570156.2 ENST00000422127.1 ENST00000366707.4 ENST00000366709.4 |
OBSCN
|
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
| chr11_-_47470591 | 1.12 |
ENST00000524487.1
|
RAPSN
|
receptor-associated protein of the synapse |
| chr22_-_36013368 | 1.09 |
ENST00000442617.1
ENST00000397326.2 ENST00000397328.1 ENST00000451685.1 |
MB
|
myoglobin |
| chr14_+_72399114 | 1.07 |
ENST00000553525.1
ENST00000555571.1 |
RGS6
|
regulator of G-protein signaling 6 |
| chr11_-_47470703 | 1.06 |
ENST00000298854.2
|
RAPSN
|
receptor-associated protein of the synapse |
| chr1_-_6269448 | 1.05 |
ENST00000465335.1
|
RPL22
|
ribosomal protein L22 |
| chr7_+_143013198 | 1.05 |
ENST00000343257.2
|
CLCN1
|
chloride channel, voltage-sensitive 1 |
| chr6_+_108977520 | 1.05 |
ENST00000540898.1
|
FOXO3
|
forkhead box O3 |
| chr4_+_37962018 | 1.04 |
ENST00000504686.1
|
PTTG2
|
pituitary tumor-transforming 2 |
| chr1_+_47901689 | 1.04 |
ENST00000334793.5
|
FOXD2
|
forkhead box D2 |
| chr6_+_34204642 | 1.04 |
ENST00000347617.6
ENST00000401473.3 ENST00000311487.5 ENST00000447654.1 ENST00000395004.3 |
HMGA1
|
high mobility group AT-hook 1 |
| chr7_-_142131914 | 1.03 |
ENST00000390375.2
|
TRBV5-6
|
T cell receptor beta variable 5-6 |
| chr22_-_31688381 | 1.03 |
ENST00000487265.2
|
PIK3IP1
|
phosphoinositide-3-kinase interacting protein 1 |
| chr19_-_42636617 | 1.03 |
ENST00000529067.1
ENST00000529952.1 ENST00000533720.1 ENST00000389341.5 ENST00000342301.4 |
POU2F2
|
POU class 2 homeobox 2 |
| chr11_-_47470682 | 1.03 |
ENST00000529341.1
ENST00000352508.3 |
RAPSN
|
receptor-associated protein of the synapse |
| chr19_-_46526304 | 1.01 |
ENST00000008938.4
|
PGLYRP1
|
peptidoglycan recognition protein 1 |
| chr14_+_22520762 | 1.00 |
ENST00000390449.3
|
TRAV21
|
T cell receptor alpha variable 21 |
| chr11_+_122709200 | 1.00 |
ENST00000227348.4
|
CRTAM
|
cytotoxic and regulatory T cell molecule |
| chr19_-_10450328 | 0.99 |
ENST00000160262.5
|
ICAM3
|
intercellular adhesion molecule 3 |
| chr6_+_41021027 | 0.99 |
ENST00000244669.2
|
APOBEC2
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 |
| chr3_-_18466026 | 0.99 |
ENST00000417717.2
|
SATB1
|
SATB homeobox 1 |
| chr15_+_81489213 | 0.98 |
ENST00000559383.1
ENST00000394660.2 |
IL16
|
interleukin 16 |
| chr1_-_207095324 | 0.97 |
ENST00000530505.1
ENST00000367091.3 ENST00000442471.2 |
FAIM3
|
Fas apoptotic inhibitory molecule 3 |
| chr5_-_88119580 | 0.97 |
ENST00000539796.1
|
MEF2C
|
myocyte enhancer factor 2C |
| chr13_+_30510003 | 0.97 |
ENST00000400540.1
|
LINC00544
|
long intergenic non-protein coding RNA 544 |
| chr4_+_78079570 | 0.95 |
ENST00000509972.1
|
CCNG2
|
cyclin G2 |
| chr1_+_158325684 | 0.93 |
ENST00000368162.2
|
CD1E
|
CD1e molecule |
| chr22_-_51016846 | 0.93 |
ENST00000312108.7
ENST00000395650.2 |
CPT1B
|
carnitine palmitoyltransferase 1B (muscle) |
| chr6_-_41168920 | 0.93 |
ENST00000483722.1
|
TREML2
|
triggering receptor expressed on myeloid cells-like 2 |
| chr16_-_50715196 | 0.93 |
ENST00000423026.2
|
SNX20
|
sorting nexin 20 |
| chr19_-_51875894 | 0.91 |
ENST00000600427.1
ENST00000595217.1 ENST00000221978.5 |
NKG7
|
natural killer cell group 7 sequence |
| chr2_+_174219548 | 0.91 |
ENST00000347703.3
ENST00000392567.2 ENST00000306721.3 ENST00000410101.3 ENST00000410019.3 |
CDCA7
|
cell division cycle associated 7 |
| chr15_+_89182178 | 0.91 |
ENST00000559876.1
|
ISG20
|
interferon stimulated exonuclease gene 20kDa |
| chr1_-_72748140 | 0.90 |
ENST00000434200.1
|
NEGR1
|
neuronal growth regulator 1 |
| chr12_+_65672423 | 0.90 |
ENST00000355192.3
ENST00000308259.5 ENST00000540804.1 ENST00000535664.1 ENST00000541189.1 |
MSRB3
|
methionine sulfoxide reductase B3 |
| chr6_-_31560729 | 0.89 |
ENST00000340027.5
ENST00000376073.4 ENST00000376072.3 |
NCR3
|
natural cytotoxicity triggering receptor 3 |
| chr13_+_28195988 | 0.88 |
ENST00000399697.3
ENST00000399696.1 |
POLR1D
|
polymerase (RNA) I polypeptide D, 16kDa |
| chr9_+_125137565 | 0.88 |
ENST00000373698.5
|
PTGS1
|
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
| chr22_-_30662828 | 0.87 |
ENST00000403463.1
ENST00000215781.2 |
OSM
|
oncostatin M |
| chr20_+_48884002 | 0.86 |
ENST00000425497.1
ENST00000445003.1 |
RP11-290F20.3
|
RP11-290F20.3 |
| chr16_-_50715239 | 0.84 |
ENST00000330943.4
ENST00000300590.3 |
SNX20
|
sorting nexin 20 |
| chr18_-_52969844 | 0.84 |
ENST00000561831.3
|
TCF4
|
transcription factor 4 |
| chr3_+_45986511 | 0.84 |
ENST00000458629.1
ENST00000457814.1 |
CXCR6
|
chemokine (C-X-C motif) receptor 6 |
| chr17_+_34430980 | 0.84 |
ENST00000250151.4
|
CCL4
|
chemokine (C-C motif) ligand 4 |
| chr19_+_39786962 | 0.83 |
ENST00000333625.2
|
IFNL1
|
interferon, lambda 1 |
| chr22_+_38597889 | 0.83 |
ENST00000338483.2
ENST00000538320.1 ENST00000538999.1 ENST00000441709.1 |
MAFF
|
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| chr6_+_83073952 | 0.81 |
ENST00000543496.1
|
TPBG
|
trophoblast glycoprotein |
| chr17_+_68165657 | 0.81 |
ENST00000243457.3
|
KCNJ2
|
potassium inwardly-rectifying channel, subfamily J, member 2 |
| chr16_+_30675654 | 0.81 |
ENST00000287468.5
ENST00000395073.2 |
FBRS
|
fibrosin |
| chr19_+_51358191 | 0.81 |
ENST00000593997.1
ENST00000595952.1 ENST00000360617.3 ENST00000598145.1 |
KLK3
|
kallikrein-related peptidase 3 |
| chr2_+_29336855 | 0.81 |
ENST00000404424.1
|
CLIP4
|
CAP-GLY domain containing linker protein family, member 4 |
| chr14_-_23877474 | 0.80 |
ENST00000405093.3
|
MYH6
|
myosin, heavy chain 6, cardiac muscle, alpha |
| chr1_+_165513231 | 0.80 |
ENST00000294818.1
|
LRRC52
|
leucine rich repeat containing 52 |
| chr4_-_102268708 | 0.80 |
ENST00000525819.1
|
PPP3CA
|
protein phosphatase 3, catalytic subunit, alpha isozyme |
| chr6_-_130182410 | 0.80 |
ENST00000368143.1
|
TMEM244
|
transmembrane protein 244 |
| chr15_+_89182156 | 0.79 |
ENST00000379224.5
|
ISG20
|
interferon stimulated exonuclease gene 20kDa |
| chr19_-_10450287 | 0.79 |
ENST00000589261.1
ENST00000590569.1 ENST00000589580.1 ENST00000589249.1 |
ICAM3
|
intercellular adhesion molecule 3 |
| chr5_+_110559312 | 0.79 |
ENST00000508074.1
|
CAMK4
|
calcium/calmodulin-dependent protein kinase IV |
| chr1_-_205290865 | 0.78 |
ENST00000367157.3
|
NUAK2
|
NUAK family, SNF1-like kinase, 2 |
| chr19_+_51358166 | 0.77 |
ENST00000601503.1
ENST00000326003.2 ENST00000597286.1 ENST00000597483.1 |
KLK3
|
kallikrein-related peptidase 3 |
| chr1_-_153917700 | 0.76 |
ENST00000368646.2
|
DENND4B
|
DENN/MADD domain containing 4B |
| chr15_+_89181974 | 0.76 |
ENST00000306072.5
|
ISG20
|
interferon stimulated exonuclease gene 20kDa |
| chr15_+_86685227 | 0.75 |
ENST00000441037.2
|
AGBL1
|
ATP/GTP binding protein-like 1 |
| chrX_+_95939711 | 0.75 |
ENST00000373049.4
ENST00000324765.8 |
DIAPH2
|
diaphanous-related formin 2 |
| chr5_-_176936844 | 0.74 |
ENST00000510380.1
ENST00000510898.1 ENST00000357198.4 |
DOK3
|
docking protein 3 |
| chr12_+_58148842 | 0.73 |
ENST00000266643.5
|
MARCH9
|
membrane-associated ring finger (C3HC4) 9 |
| chr5_-_88120151 | 0.73 |
ENST00000506716.1
|
MEF2C
|
myocyte enhancer factor 2C |
| chrX_-_106959631 | 0.71 |
ENST00000486554.1
ENST00000372390.4 |
TSC22D3
|
TSC22 domain family, member 3 |
| chr11_-_46142948 | 0.71 |
ENST00000257821.4
|
PHF21A
|
PHD finger protein 21A |
| chr9_+_125133467 | 0.71 |
ENST00000426608.1
|
PTGS1
|
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
| chr13_-_79177673 | 0.70 |
ENST00000377208.5
|
POU4F1
|
POU class 4 homeobox 1 |
| chr2_-_109605663 | 0.70 |
ENST00000409271.1
ENST00000258443.2 ENST00000376651.1 |
EDAR
|
ectodysplasin A receptor |
| chr19_+_55085248 | 0.70 |
ENST00000391738.3
ENST00000251376.3 ENST00000391737.1 ENST00000396321.2 ENST00000418536.2 ENST00000448689.1 |
LILRA2
LILRB1
|
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
| chr19_+_41856816 | 0.70 |
ENST00000539627.1
|
TMEM91
|
transmembrane protein 91 |
| chr9_+_125133315 | 0.69 |
ENST00000223423.4
ENST00000362012.2 |
PTGS1
|
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
| chr2_+_201994042 | 0.68 |
ENST00000417748.1
|
CFLAR
|
CASP8 and FADD-like apoptosis regulator |
| chr17_+_37821593 | 0.68 |
ENST00000578283.1
|
TCAP
|
titin-cap |
| chr2_-_89521942 | 0.68 |
ENST00000482769.1
|
IGKV2-28
|
immunoglobulin kappa variable 2-28 |
| chr11_+_46354455 | 0.68 |
ENST00000343674.6
|
DGKZ
|
diacylglycerol kinase, zeta |
| chr1_-_235116495 | 0.68 |
ENST00000549744.1
|
RP11-443B7.3
|
RP11-443B7.3 |
| chr14_+_75745477 | 0.68 |
ENST00000303562.4
ENST00000554617.1 ENST00000554212.1 ENST00000535987.1 ENST00000555242.1 |
FOS
|
FBJ murine osteosarcoma viral oncogene homolog |
| chr19_-_47734448 | 0.67 |
ENST00000439096.2
|
BBC3
|
BCL2 binding component 3 |
| chr2_+_68962014 | 0.67 |
ENST00000467265.1
|
ARHGAP25
|
Rho GTPase activating protein 25 |
| chr5_-_142784888 | 0.67 |
ENST00000514699.1
|
NR3C1
|
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| chr6_+_167536230 | 0.67 |
ENST00000341935.5
ENST00000349984.4 |
CCR6
|
chemokine (C-C motif) receptor 6 |
| chr18_+_54318893 | 0.67 |
ENST00000593058.1
|
WDR7
|
WD repeat domain 7 |
| chr19_+_51376505 | 0.66 |
ENST00000325321.3
ENST00000600690.1 ENST00000391810.2 ENST00000358049.4 |
KLK2
|
kallikrein-related peptidase 2 |
| chr3_+_63897605 | 0.65 |
ENST00000487717.1
|
ATXN7
|
ataxin 7 |
| chr1_-_6269304 | 0.65 |
ENST00000471204.1
|
RPL22
|
ribosomal protein L22 |
| chr12_+_56511943 | 0.65 |
ENST00000257940.2
ENST00000552345.1 ENST00000551880.1 ENST00000546903.1 ENST00000551790.1 |
ZC3H10
ESYT1
|
zinc finger CCCH-type containing 10 extended synaptotagmin-like protein 1 |
| chr5_-_74348371 | 0.65 |
ENST00000503568.1
|
RP11-229C3.2
|
RP11-229C3.2 |
| chrX_+_95939638 | 0.65 |
ENST00000373061.3
ENST00000373054.4 ENST00000355827.4 |
DIAPH2
|
diaphanous-related formin 2 |
| chr22_+_40441456 | 0.64 |
ENST00000402203.1
|
TNRC6B
|
trinucleotide repeat containing 6B |
| chr8_-_27336747 | 0.64 |
ENST00000240132.2
ENST00000407991.1 |
CHRNA2
|
cholinergic receptor, nicotinic, alpha 2 (neuronal) |
| chr14_-_91526462 | 0.64 |
ENST00000536315.2
|
RPS6KA5
|
ribosomal protein S6 kinase, 90kDa, polypeptide 5 |
| chr3_+_167453026 | 0.63 |
ENST00000472941.1
|
SERPINI1
|
serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
| chr11_-_3147835 | 0.63 |
ENST00000525498.1
|
OSBPL5
|
oxysterol binding protein-like 5 |
| chr17_-_1588101 | 0.63 |
ENST00000577001.1
ENST00000572621.1 ENST00000304992.6 |
PRPF8
|
pre-mRNA processing factor 8 |
| chr5_-_180229791 | 0.62 |
ENST00000504671.1
ENST00000507384.1 |
MGAT1
|
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
| chr2_-_163099546 | 0.61 |
ENST00000447386.1
|
FAP
|
fibroblast activation protein, alpha |
| chr8_-_144654918 | 0.61 |
ENST00000529971.1
|
MROH6
|
maestro heat-like repeat family member 6 |
| chr2_+_68961934 | 0.61 |
ENST00000409202.3
|
ARHGAP25
|
Rho GTPase activating protein 25 |
| chr17_-_61959202 | 0.61 |
ENST00000449787.2
ENST00000456543.2 ENST00000423893.2 ENST00000332800.7 |
GH2
|
growth hormone 2 |
| chr19_-_42931567 | 0.61 |
ENST00000244289.4
|
LIPE
|
lipase, hormone-sensitive |
| chr19_-_41934635 | 0.60 |
ENST00000321702.2
|
B3GNT8
|
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 |
| chr2_+_191334212 | 0.60 |
ENST00000444317.1
ENST00000535751.1 |
MFSD6
|
major facilitator superfamily domain containing 6 |
| chr12_-_116714564 | 0.60 |
ENST00000548743.1
|
MED13L
|
mediator complex subunit 13-like |
| chr6_+_45389893 | 0.60 |
ENST00000371432.3
|
RUNX2
|
runt-related transcription factor 2 |
| chr4_-_102268628 | 0.59 |
ENST00000323055.6
ENST00000512215.1 ENST00000394854.3 |
PPP3CA
|
protein phosphatase 3, catalytic subunit, alpha isozyme |
| chr15_+_91416092 | 0.59 |
ENST00000559353.1
|
FURIN
|
furin (paired basic amino acid cleaving enzyme) |
| chr5_-_145562147 | 0.59 |
ENST00000545646.1
ENST00000274562.9 ENST00000510191.1 ENST00000394434.2 |
LARS
|
leucyl-tRNA synthetase |
| chr17_+_74372662 | 0.58 |
ENST00000591651.1
ENST00000545180.1 |
SPHK1
|
sphingosine kinase 1 |
| chr10_-_131762105 | 0.58 |
ENST00000368648.3
ENST00000355311.5 |
EBF3
|
early B-cell factor 3 |
| chr20_+_57875457 | 0.58 |
ENST00000337938.2
ENST00000311585.7 ENST00000371028.2 |
EDN3
|
endothelin 3 |
| chr15_+_81589254 | 0.57 |
ENST00000394652.2
|
IL16
|
interleukin 16 |
| chr2_+_89998789 | 0.57 |
ENST00000453166.2
|
IGKV2D-28
|
immunoglobulin kappa variable 2D-28 |
| chr2_+_68961905 | 0.57 |
ENST00000295381.3
|
ARHGAP25
|
Rho GTPase activating protein 25 |
| chr17_-_7297519 | 0.57 |
ENST00000576362.1
ENST00000571078.1 |
TMEM256-PLSCR3
|
TMEM256-PLSCR3 readthrough (NMD candidate) |
| chr19_+_38794797 | 0.57 |
ENST00000301246.5
ENST00000588605.1 |
C19orf33
|
chromosome 19 open reading frame 33 |
| chr22_+_38609538 | 0.57 |
ENST00000407965.1
|
MAFF
|
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| chr8_+_123793633 | 0.56 |
ENST00000314393.4
|
ZHX2
|
zinc fingers and homeoboxes 2 |
| chr17_+_34431212 | 0.56 |
ENST00000394495.1
|
CCL4
|
chemokine (C-C motif) ligand 4 |
| chr3_+_35722844 | 0.56 |
ENST00000436702.1
ENST00000438071.1 |
ARPP21
|
cAMP-regulated phosphoprotein, 21kDa |
| chr17_-_37934466 | 0.56 |
ENST00000583368.1
|
IKZF3
|
IKAROS family zinc finger 3 (Aiolos) |
| chr6_+_292253 | 0.55 |
ENST00000603453.1
ENST00000605315.1 ENST00000603881.1 |
DUSP22
|
dual specificity phosphatase 22 |
| chr22_-_51017084 | 0.55 |
ENST00000360719.2
ENST00000457250.1 ENST00000440709.1 |
CPT1B
|
carnitine palmitoyltransferase 1B (muscle) |
| chr4_+_81118647 | 0.54 |
ENST00000415738.2
|
PRDM8
|
PR domain containing 8 |
| chr5_-_176936817 | 0.54 |
ENST00000502885.1
ENST00000506493.1 |
DOK3
|
docking protein 3 |
| chr17_-_61973929 | 0.54 |
ENST00000329882.8
ENST00000453363.3 ENST00000316193.8 |
CSH1
|
chorionic somatomammotropin hormone 1 (placental lactogen) |
| chr21_+_17214724 | 0.54 |
ENST00000449491.1
|
USP25
|
ubiquitin specific peptidase 25 |
| chr5_-_88120083 | 0.53 |
ENST00000509373.1
|
MEF2C
|
myocyte enhancer factor 2C |
| chr14_+_90864504 | 0.53 |
ENST00000544280.2
|
CALM1
|
calmodulin 1 (phosphorylase kinase, delta) |
| chr10_-_31320860 | 0.53 |
ENST00000436087.2
ENST00000442986.1 ENST00000413025.1 ENST00000452305.1 |
ZNF438
|
zinc finger protein 438 |
| chr17_-_7297833 | 0.53 |
ENST00000571802.1
ENST00000576201.1 ENST00000573213.1 ENST00000324822.11 |
TMEM256-PLSCR3
|
TMEM256-PLSCR3 readthrough (NMD candidate) |
| chr13_+_24844979 | 0.53 |
ENST00000454083.1
|
SPATA13
|
spermatogenesis associated 13 |
| chr3_+_167453493 | 0.53 |
ENST00000295777.5
ENST00000472747.2 |
SERPINI1
|
serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
| chr6_-_130536774 | 0.53 |
ENST00000532763.1
|
SAMD3
|
sterile alpha motif domain containing 3 |
| chr3_+_49726932 | 0.53 |
ENST00000327697.6
ENST00000432042.1 ENST00000454491.1 |
RNF123
|
ring finger protein 123 |
| chrX_+_123097014 | 0.52 |
ENST00000394478.1
|
STAG2
|
stromal antigen 2 |
| chr7_+_16700806 | 0.51 |
ENST00000446596.1
ENST00000438834.1 |
BZW2
|
basic leucine zipper and W2 domains 2 |
| chr7_+_139529085 | 0.51 |
ENST00000539806.1
|
TBXAS1
|
thromboxane A synthase 1 (platelet) |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 1.3 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) |
| 1.1 | 3.2 | GO:1900073 | regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075) |
| 0.6 | 1.8 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.5 | 2.5 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.5 | 1.8 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.4 | 2.2 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.4 | 2.1 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.4 | 1.2 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.4 | 2.9 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 0.4 | 1.2 | GO:2000870 | positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870) |
| 0.4 | 2.6 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.4 | 1.4 | GO:0051710 | regulation of cytolysis in other organism(GO:0051710) |
| 0.3 | 1.0 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.3 | 1.0 | GO:0006425 | glutaminyl-tRNA aminoacylation(GO:0006425) |
| 0.3 | 0.6 | GO:1990164 | histone H2A phosphorylation(GO:1990164) |
| 0.3 | 1.2 | GO:0060262 | regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060) |
| 0.3 | 0.9 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.3 | 0.8 | GO:0002372 | myeloid dendritic cell cytokine production(GO:0002372) |
| 0.3 | 1.8 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.3 | 1.3 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 8.2 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.2 | 1.0 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 0.2 | 2.2 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.2 | 1.2 | GO:0002351 | serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554) |
| 0.2 | 0.7 | GO:0042489 | negative regulation of odontogenesis of dentin-containing tooth(GO:0042489) |
| 0.2 | 1.0 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.2 | 0.6 | GO:1902362 | melanocyte apoptotic process(GO:1902362) |
| 0.2 | 0.6 | GO:0019082 | viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 0.2 | 0.6 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.2 | 1.1 | GO:0036309 | protein localization to M-band(GO:0036309) |
| 0.2 | 0.5 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.2 | 0.7 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.2 | 0.7 | GO:0002290 | gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193) |
| 0.2 | 1.4 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
| 0.2 | 1.9 | GO:2000332 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.2 | 1.5 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 1.2 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.2 | 0.5 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
| 0.2 | 2.1 | GO:0030091 | protein repair(GO:0030091) |
| 0.2 | 3.6 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.2 | 1.6 | GO:1904379 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.2 | 0.5 | GO:0060032 | notochord regression(GO:0060032) |
| 0.2 | 0.5 | GO:0021776 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.2 | 0.3 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.2 | 2.2 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.2 | 4.4 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 1.6 | GO:0002775 | antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) |
| 0.1 | 0.4 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.1 | 0.4 | GO:0090222 | centrosome-templated microtubule nucleation(GO:0090222) |
| 0.1 | 1.1 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.1 | 0.7 | GO:0060474 | positive regulation of sperm motility involved in capacitation(GO:0060474) |
| 0.1 | 0.4 | GO:0021586 | pons maturation(GO:0021586) superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.1 | 1.2 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 0.4 | GO:0097198 | histone H3-K36 trimethylation(GO:0097198) |
| 0.1 | 2.7 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 0.5 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.1 | 0.6 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.1 | 0.4 | GO:0021934 | medulla oblongata development(GO:0021550) hindbrain tangential cell migration(GO:0021934) lateral line system development(GO:0048925) |
| 0.1 | 0.6 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.1 | 1.0 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 2.0 | GO:0060088 | auditory receptor cell stereocilium organization(GO:0060088) |
| 0.1 | 1.9 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 0.3 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.1 | 0.1 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) |
| 0.1 | 1.2 | GO:0045345 | positive regulation of MHC class I biosynthetic process(GO:0045345) |
| 0.1 | 0.4 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 0.1 | 0.7 | GO:0014826 | cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826) |
| 0.1 | 1.0 | GO:0002857 | positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.1 | 1.0 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.1 | 0.3 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.1 | 0.7 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 0.1 | 0.8 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.2 | GO:0003241 | growth involved in heart morphogenesis(GO:0003241) |
| 0.1 | 0.7 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.1 | 0.5 | GO:0010536 | positive regulation of activation of Janus kinase activity(GO:0010536) |
| 0.1 | 0.6 | GO:0019075 | virus maturation(GO:0019075) |
| 0.1 | 1.0 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.1 | 1.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 5.1 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 0.4 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.1 | 0.4 | GO:0021778 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.1 | 0.5 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.1 | 1.5 | GO:0033005 | positive regulation of mast cell activation(GO:0033005) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.1 | 0.9 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.1 | 3.4 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 0.4 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.1 | 1.8 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.1 | 0.2 | GO:0061366 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 0.3 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
| 0.1 | 0.4 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.1 | 0.4 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.1 | 1.0 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 1.0 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.5 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 1.6 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.1 | 2.3 | GO:0002335 | mature B cell differentiation(GO:0002335) |
| 0.1 | 0.7 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.1 | 0.5 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.1 | 0.3 | GO:0046778 | modification by virus of host mRNA processing(GO:0046778) |
| 0.1 | 0.2 | GO:0051389 | inactivation of MAPKK activity(GO:0051389) |
| 0.1 | 1.4 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.1 | 0.6 | GO:0038129 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.1 | 0.4 | GO:0071233 | cellular response to leucine(GO:0071233) |
| 0.1 | 0.2 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 0.1 | 1.3 | GO:0003323 | type B pancreatic cell development(GO:0003323) |
| 0.1 | 0.4 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.1 | 0.2 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.1 | 0.3 | GO:0033563 | dorsal/ventral axon guidance(GO:0033563) |
| 0.1 | 0.3 | GO:0018057 | peptidyl-lysine oxidation(GO:0018057) |
| 0.0 | 0.8 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 0.8 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.6 | GO:0040033 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 1.2 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 0.3 | GO:0060154 | response to cycloheximide(GO:0046898) cellular process regulating host cell cycle in response to virus(GO:0060154) |
| 0.0 | 1.1 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 0.0 | 0.1 | GO:0045720 | negative regulation of integrin biosynthetic process(GO:0045720) |
| 0.0 | 0.3 | GO:0034959 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.0 | 0.7 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 0.7 | GO:0060605 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.0 | 1.3 | GO:0007567 | parturition(GO:0007567) |
| 0.0 | 0.3 | GO:0046984 | regulation of hemoglobin biosynthetic process(GO:0046984) |
| 0.0 | 0.3 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.0 | 0.1 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.0 | 3.3 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.2 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.0 | 0.3 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.0 | 0.8 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.0 | 0.6 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.0 | 2.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.3 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.0 | 0.8 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 0.0 | 0.5 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.0 | 0.1 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.0 | 0.3 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.0 | 0.2 | GO:0042335 | cuticle development(GO:0042335) |
| 0.0 | 0.4 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 0.0 | 0.2 | GO:2000490 | negative regulation of hepatic stellate cell activation(GO:2000490) |
| 0.0 | 0.5 | GO:1904293 | negative regulation of ERAD pathway(GO:1904293) |
| 0.0 | 0.1 | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177) |
| 0.0 | 2.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 0.7 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.0 | 1.3 | GO:0033198 | response to ATP(GO:0033198) |
| 0.0 | 0.1 | GO:0014908 | myotube differentiation involved in skeletal muscle regeneration(GO:0014908) |
| 0.0 | 0.2 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.0 | 0.6 | GO:0007379 | segment specification(GO:0007379) |
| 0.0 | 0.6 | GO:0048757 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.0 | 0.3 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.0 | 0.1 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
| 0.0 | 0.1 | GO:1902595 | regulation of DNA replication origin binding(GO:1902595) |
| 0.0 | 0.1 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.0 | 0.1 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.0 | 0.5 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 0.2 | GO:2000344 | positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 0.1 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.0 | 0.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.0 | 0.5 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
| 0.0 | 0.1 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
| 0.0 | 0.7 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.2 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.0 | 0.1 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.0 | 0.4 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.2 | GO:0060052 | positive regulation of axon regeneration(GO:0048680) neurofilament cytoskeleton organization(GO:0060052) |
| 0.0 | 0.1 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.0 | 0.4 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.0 | 0.6 | GO:0045577 | regulation of B cell differentiation(GO:0045577) |
| 0.0 | 0.1 | GO:1902564 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) negative regulation of neutrophil activation(GO:1902564) |
| 0.0 | 0.3 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.2 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.0 | 0.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 1.0 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 0.0 | 0.7 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.0 | 0.7 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.0 | 0.2 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.0 | 0.4 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.7 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.5 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 0.1 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 0.1 | GO:0039019 | pronephric nephron development(GO:0039019) |
| 0.0 | 0.5 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 0.7 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) |
| 0.0 | 0.1 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.0 | 0.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.3 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.1 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 0.0 | 2.3 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.1 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
| 0.0 | 0.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 0.1 | GO:0070602 | regulation of centromeric sister chromatid cohesion(GO:0070602) |
| 0.0 | 0.1 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 0.0 | 0.2 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.0 | 0.2 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.0 | 1.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.2 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.0 | 0.5 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.2 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.3 | GO:0006914 | autophagy(GO:0006914) |
| 0.0 | 0.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 0.4 | GO:0045618 | positive regulation of keratinocyte differentiation(GO:0045618) |
| 0.0 | 0.2 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 1.3 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.0 | 0.8 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.0 | 0.2 | GO:0030238 | male sex determination(GO:0030238) |
| 0.0 | 0.2 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.0 | 0.3 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 0.4 | GO:0051904 | melanosome transport(GO:0032402) pigment granule transport(GO:0051904) |
| 0.0 | 0.3 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.0 | 1.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.1 | GO:0010482 | epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) |
| 0.0 | 0.6 | GO:0009790 | embryo development(GO:0009790) |
| 0.0 | 0.5 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.0 | 0.5 | GO:0010165 | response to X-ray(GO:0010165) |
| 0.0 | 0.3 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 0.2 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.3 | 2.3 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.2 | 5.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 1.1 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.2 | 1.5 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.2 | 3.1 | GO:0099634 | postsynaptic specialization membrane(GO:0099634) |
| 0.2 | 1.8 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 0.5 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.2 | 0.7 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 1.0 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.1 | 1.6 | GO:0072379 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.1 | 0.4 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 0.4 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 0.5 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 1.0 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 2.1 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.4 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.1 | 1.4 | GO:0031264 | death-inducing signaling complex(GO:0031264) |
| 0.1 | 0.7 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.0 | 0.3 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.0 | 0.7 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 1.0 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 1.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.1 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.0 | 0.8 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 0.3 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.0 | 0.8 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.2 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.0 | 0.4 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.6 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.2 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.0 | 3.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 2.1 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 2.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.4 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 0.4 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.0 | 5.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.2 | GO:0071203 | WASH complex(GO:0071203) |
| 0.0 | 1.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.7 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 0.6 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 0.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 0.6 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.2 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 0.4 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.1 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.0 | 1.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.3 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 7.2 | GO:0030016 | myofibril(GO:0030016) |
| 0.0 | 0.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 4.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.5 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.8 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.0 | 0.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 1.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 1.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.3 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 0.5 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.5 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.0 | 1.0 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 1.2 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.0 | GO:0002947 | tumor necrosis factor receptor superfamily complex(GO:0002947) |
| 0.0 | 0.4 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 0.1 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 1.6 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 1.5 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 0.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 0.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.1 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.4 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.7 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.1 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.1 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 0.8 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 3.5 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
| 0.8 | 2.5 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.7 | 2.2 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.5 | 2.3 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.4 | 1.3 | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity(GO:0004676) |
| 0.3 | 1.4 | GO:0004913 | interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917) |
| 0.3 | 2.7 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.3 | 1.3 | GO:0036134 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.3 | 1.0 | GO:0004819 | glutamine-tRNA ligase activity(GO:0004819) |
| 0.3 | 8.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.3 | 2.1 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.3 | 2.9 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.3 | 1.9 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.3 | 1.0 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.2 | 1.2 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.2 | 2.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.2 | 1.7 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.2 | 0.6 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.2 | 1.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.2 | 1.1 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.2 | 0.5 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.2 | 0.7 | GO:0030107 | HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) |
| 0.2 | 1.9 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.2 | 1.2 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.2 | 1.2 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.1 | 0.4 | GO:0001156 | TFIIIC-class transcription factor binding(GO:0001156) |
| 0.1 | 0.4 | GO:0035034 | histone acetyltransferase regulator activity(GO:0035034) |
| 0.1 | 0.3 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.1 | 0.7 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.5 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.1 | 0.4 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.1 | 0.4 | GO:0045518 | interleukin-22 receptor binding(GO:0045518) |
| 0.1 | 2.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 1.2 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 1.8 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 0.6 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.1 | 0.4 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.1 | 3.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.1 | 1.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 1.0 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 1.8 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 5.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.0 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 0.4 | GO:0001632 | leukotriene B4 receptor activity(GO:0001632) |
| 0.1 | 0.5 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 1.2 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.6 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.1 | 0.5 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.1 | 0.9 | GO:0030882 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.1 | 0.8 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 0.1 | 2.0 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.1 | 0.6 | GO:0008481 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.3 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.1 | 1.7 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.4 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.1 | 0.7 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.1 | 3.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.4 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 0.8 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 0.3 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.1 | 1.6 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 0.5 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.1 | 1.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 0.4 | GO:0070513 | death domain binding(GO:0070513) |
| 0.1 | 0.2 | GO:0016652 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.1 | 1.6 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 0.8 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958) |
| 0.1 | 1.1 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 1.1 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 0.4 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.0 | 1.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.7 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.2 | GO:0070012 | oligopeptidase activity(GO:0070012) |
| 0.0 | 0.2 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.0 | 0.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 2.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.3 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.0 | 0.9 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.2 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.0 | 0.5 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.8 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.4 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 2.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.5 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 1.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 2.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.3 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 1.7 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.4 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.3 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.0 | 0.7 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.1 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.0 | 0.2 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
| 0.0 | 0.3 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 0.3 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.0 | 0.6 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 1.0 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.4 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.0 | 0.1 | GO:0003875 | ADP-ribosylarginine hydrolase activity(GO:0003875) |
| 0.0 | 2.8 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.7 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.4 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 0.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.3 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
| 0.0 | 0.1 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.0 | 0.1 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.0 | 2.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 2.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 0.4 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.0 | 0.3 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.2 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.1 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.0 | 0.1 | GO:0098988 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988) |
| 0.0 | 0.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.3 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 0.1 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.0 | 0.3 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.0 | 0.1 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.0 | 0.1 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.0 | 0.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.0 | 0.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.1 | GO:0034191 | apolipoprotein A-I receptor binding(GO:0034191) |
| 0.0 | 0.1 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.0 | 0.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.6 | GO:0001221 | transcription cofactor binding(GO:0001221) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 2.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 4.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 2.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 3.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 3.2 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 3.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.2 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 3.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 4.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.3 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 3.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 1.7 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.8 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.8 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 1.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.2 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 0.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.4 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 2.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.6 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.4 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.0 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 0.4 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 1.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 2.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 3.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 1.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.1 | 2.6 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 4.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.4 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 1.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 0.6 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 1.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.0 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 5.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.2 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 1.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 2.6 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 2.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 2.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.6 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 2.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.8 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME PI3K EVENTS IN ERBB4 SIGNALING | Genes involved in PI3K events in ERBB4 signaling |
| 0.0 | 1.4 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.6 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.7 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.0 | 1.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.2 | REACTOME PI3K AKT ACTIVATION | Genes involved in PI3K/AKT activation |
| 0.0 | 1.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 2.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.3 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.6 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.2 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 2.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.3 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 0.0 | 0.3 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.0 | 0.1 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.0 | 2.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.3 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.6 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.1 | REACTOME TRANSCRIPTION COUPLED NER TC NER | Genes involved in Transcription-coupled NER (TC-NER) |
| 0.0 | 0.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |