ISMARA results: TCF7

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Illumina Body Map 2: averaged replicates

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Results for TCF7

Z-value: 1.65

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Transcription factors associated with TCF7

Gene Symbol	Gene ID	Gene Info
TCF7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000081059.15	transcription factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF7	hg19_v2_chr5_+_133477868_133477885	-0.59	3.3e-04	Click!

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_68100989 Show fit	4.41	ENST00000585558.1 ENST00000392670.1	KCNJ16 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 16
chr8_+_133879193 Show fit	4.38	ENST00000377869.1 ENST00000220616.4	TG Ensembl NCBI GeneCards UniProt NextProt Show fit	thyroglobulin
chr2_-_217560248 Show fit	4.36	ENST00000233813.4	IGFBP5 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin-like growth factor binding protein 5
chr8_-_119964434 Show fit	3.70	ENST00000297350.4	TNFRSF11B Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor receptor superfamily, member 11b
chr4_-_186682716 Show fit	3.44	ENST00000445343.1	SORBS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	sorbin and SH3 domain containing 2
chr1_-_79472365 Show fit	3.37	ENST00000370742.3	ELTD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	EGF, latrophilin and seven transmembrane domain containing 1
chr10_+_99332198 Show fit	3.05	ENST00000307518.5 ENST00000298808.5 ENST00000370655.1	ANKRD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin repeat domain 2 (stretch responsive muscle)
chr2_+_234621551 Show fit	3.01	ENST00000608381.1 ENST00000373414.3	UGT1A1 Ensembl NCBI GeneCards UniProt NextProt Show fit UGT1A5 Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A8 UDP glucuronosyltransferase 1 family, polypeptide A5
chr1_-_16345245 Show fit	2.87	ENST00000311890.9	HSPB7 Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 27kDa protein family, member 7 (cardiovascular)
chr18_-_56296182 Show fit	2.74	ENST00000361673.3	ALPK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-kinase 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.5	GO:0010107	potassium ion import(GO:0010107)
0.2	5.0	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.9	4.7	GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.9	4.5	GO:0070980	biphenyl catabolic process(GO:0070980)
0.7	4.5	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
1.5	4.4	GO:1904204	regulation of skeletal muscle hypertrophy(GO:1904204)
0.5	4.4	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.3	4.4	GO:0015705	iodide transport(GO:0015705)
0.0	4.2	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.1	4.0	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)

Showing 1 to 10 of 152 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	7.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.4	6.3	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	6.1	GO:0016323	basolateral plasma membrane(GO:0016323)
1.6	4.7	GO:0043257	laminin-8 complex(GO:0043257)
0.2	4.6	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.4	4.4	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
0.1	4.4	GO:0005605	basal lamina(GO:0005605)
0.1	4.4	GO:0016235	aggresome(GO:0016235)
0.1	4.3	GO:0032982	myosin filament(GO:0032982)

Showing 1 to 10 of 64 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.2	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.1	8.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	6.8	GO:0001972	retinoic acid binding(GO:0001972)
0.3	6.2	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2	4.5	GO:0045499	chemorepellent activity(GO:0045499)
0.3	4.4	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.2	4.4	GO:0008179	adenylate cyclase binding(GO:0008179)
0.1	4.4	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	4.0	GO:0005179	hormone activity(GO:0005179)
0.2	3.7	GO:0031432	titin binding(GO:0031432)

Showing 1 to 10 of 111 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	5.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	4.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	3.2	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	3.2	PID BMP PATHWAY	BMP receptor signaling
0.0	3.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	2.7	NABA COLLAGENS	Genes encoding collagen proteins
0.0	2.7	ST ADRENERGIC	Adrenergic Pathway
0.0	2.4	PID ENDOTHELIN PATHWAY	Endothelins
0.0	1.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.1	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	6.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	6.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	5.0	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	4.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	3.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	3.6	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	3.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	2.5	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.1	2.3	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 33 entries

Results for TCF7

Z-value: 1.65

Motif logo

Transcription factors associated with TCF7

Activity-expression correlation:

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: