Project

Illumina Body Map 2: averaged replicates

Navigation
Downloads

Results for TCF7L2

Z-value: 1.19

Motif logo

logo of

Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
TCF7L2
ENSG00000148737.11 transcription factor 7 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114710516_114710675-0.115.3e-01Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_234621551 3.13 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr13_+_24144796 2.92 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_+_24144509 2.64 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr11_+_114128522 2.60 ENST00000535401.1
NNMT
nicotinamide N-methyltransferase
chr17_-_46035187 2.59 ENST00000300557.2
PRR15L
proline rich 15-like
chr14_-_65409502 2.48 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr10_+_115312766 2.42 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr1_-_119869846 2.42 ENST00000457719.1
RP11-418J17.3
RP11-418J17.3
chr17_+_68100989 2.39 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr11_+_69455855 2.35 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr9_+_97766469 2.21 ENST00000433691.2
C9orf3
chromosome 9 open reading frame 3
chrX_-_32173579 2.17 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr9_+_97766409 2.15 ENST00000425634.2
C9orf3
chromosome 9 open reading frame 3
chr2_-_88427568 2.03 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr5_-_16936340 1.84 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr5_-_135290651 1.84 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chr12_+_108168162 1.73 ENST00000342331.4
ASCL4
achaete-scute family bHLH transcription factor 4
chr10_+_115312825 1.67 ENST00000537906.1
ENST00000541666.1
HABP2
hyaluronan binding protein 2
chr17_+_68101117 1.67 ENST00000587698.1
ENST00000587892.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr6_+_78400375 1.65 ENST00000602452.2
MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr8_-_119964434 1.60 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chrX_+_46937745 1.60 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chrX_+_106163626 1.59 ENST00000336803.1
CLDN2
claudin 2
chr19_+_50084561 1.45 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr5_-_153857819 1.45 ENST00000231121.2
HAND1
heart and neural crest derivatives expressed 1
chr10_+_7745232 1.33 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_-_241195452 1.31 ENST00000457178.1
AC124861.1
AC124861.1
chr13_+_76334795 1.21 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr13_+_76334567 1.17 ENST00000321797.8
LMO7
LIM domain 7
chr1_-_219615984 1.15 ENST00000420762.1
RP11-95P13.1
RP11-95P13.1
chr16_+_72088376 1.10 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr17_+_42081914 1.05 ENST00000293404.3
ENST00000589767.1
NAGS
N-acetylglutamate synthase
chr3_+_29323043 1.04 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr14_+_68189190 1.01 ENST00000539142.1
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr15_+_43985725 1.00 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr10_+_7745303 1.00 ENST00000429820.1
ENST00000379587.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_101542462 0.98 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr7_+_73868439 0.96 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr17_+_79679299 0.96 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr3_-_134093275 0.96 ENST00000513145.1
ENST00000422605.2
AMOTL2
angiomotin like 2
chr1_-_110933611 0.95 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr13_+_76334498 0.94 ENST00000534657.1
LMO7
LIM domain 7
chr18_+_19668021 0.93 ENST00000579830.1
RP11-595B24.2
Uncharacterized protein
chr1_-_110933663 0.92 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chr3_-_134093395 0.92 ENST00000249883.5
AMOTL2
angiomotin like 2
chr6_-_112575912 0.92 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr1_-_94079648 0.91 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr15_+_43885252 0.90 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chrX_+_152760397 0.89 ENST00000331595.4
ENST00000431891.1
BGN
biglycan
chr22_+_29279552 0.87 ENST00000544604.2
ZNRF3
zinc and ring finger 3
chr19_-_44008863 0.86 ENST00000601646.1
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr12_+_85673868 0.85 ENST00000316824.3
ALX1
ALX homeobox 1
chr7_-_27213893 0.83 ENST00000283921.4
HOXA10
homeobox A10
chr3_-_149375783 0.83 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr6_-_112575687 0.80 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chr19_-_40791160 0.80 ENST00000358335.5
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr17_-_67138015 0.79 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr7_-_148725733 0.79 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chr2_+_228678550 0.78 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chrX_+_2670066 0.77 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
XG
Xg blood group
chr2_-_171571077 0.76 ENST00000409786.1
AC007405.2
long intergenic non-protein coding RNA 1124
chr1_+_78383813 0.76 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr5_+_131593364 0.75 ENST00000253754.3
ENST00000379018.3
PDLIM4
PDZ and LIM domain 4
chr6_+_32146131 0.74 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr3_+_174577070 0.74 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr20_+_57875658 0.74 ENST00000371025.3
EDN3
endothelin 3
chr1_+_162351503 0.73 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr2_+_69240302 0.71 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr15_+_43985084 0.71 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr17_+_1674982 0.71 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_94443065 0.69 ENST00000555287.1
ASB2
ankyrin repeat and SOCS box containing 2
chr6_-_112575758 0.67 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr6_-_11779840 0.65 ENST00000506810.1
ADTRP
androgen-dependent TFPI-regulating protein
chr9_-_27005686 0.65 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr7_-_148725544 0.64 ENST00000413966.1
PDIA4
protein disulfide isomerase family A, member 4
chr4_-_65275100 0.64 ENST00000509536.1
TECRL
trans-2,3-enoyl-CoA reductase-like
chr14_-_94443105 0.63 ENST00000555019.1
ASB2
ankyrin repeat and SOCS box containing 2
chrX_-_10588595 0.63 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr6_-_25930819 0.63 ENST00000360488.3
SLC17A2
solute carrier family 17, member 2
chr5_-_16742330 0.63 ENST00000505695.1
ENST00000427430.2
MYO10
myosin X
chr11_-_76155618 0.63 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr1_+_61330931 0.63 ENST00000371191.1
NFIA
nuclear factor I/A
chrX_+_110754888 0.62 ENST00000569275.1
ENST00000563467.1
LINC00890
long intergenic non-protein coding RNA 890
chr19_-_40791211 0.62 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr4_+_30721968 0.61 ENST00000361762.2
PCDH7
protocadherin 7
chr6_-_25930904 0.61 ENST00000377850.3
SLC17A2
solute carrier family 17, member 2
chr8_-_124665190 0.60 ENST00000325995.7
KLHL38
kelch-like family member 38
chr4_+_87857538 0.60 ENST00000511442.1
AFF1
AF4/FMR2 family, member 1
chr7_-_16505440 0.60 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr16_-_73082274 0.58 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr19_-_40791302 0.57 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr2_+_171571827 0.57 ENST00000375281.3
SP5
Sp5 transcription factor
chr13_+_102142296 0.57 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_+_69240415 0.56 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr3_-_155011483 0.56 ENST00000489090.1
RP11-451G4.2
RP11-451G4.2
chr7_+_137761167 0.56 ENST00000432161.1
AKR1D1
aldo-keto reductase family 1, member D1
chr8_+_55467072 0.56 ENST00000602362.1
RP11-53M11.3
RP11-53M11.3
chr2_+_177028805 0.56 ENST00000249440.3
HOXD3
homeobox D3
chr10_-_75351088 0.54 ENST00000451492.1
ENST00000413442.1
USP54
ubiquitin specific peptidase 54
chr17_-_79919713 0.54 ENST00000425009.1
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr4_-_146859787 0.54 ENST00000508784.1
ZNF827
zinc finger protein 827
chr2_+_69240511 0.53 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr11_-_108422926 0.52 ENST00000428840.1
ENST00000526312.1
EXPH5
exophilin 5
chr10_+_54074033 0.52 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr20_-_656437 0.52 ENST00000488788.2
RP5-850E9.3
Uncharacterized protein
chr7_+_137761220 0.51 ENST00000242375.3
ENST00000438242.1
AKR1D1
aldo-keto reductase family 1, member D1
chr9_+_136399929 0.50 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr17_+_70026795 0.49 ENST00000472655.2
ENST00000538810.1
RP11-84E24.3
long intergenic non-protein coding RNA 1152
chr9_+_128510454 0.48 ENST00000491787.3
ENST00000447726.2
PBX3
pre-B-cell leukemia homeobox 3
chr5_+_140235469 0.48 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr5_-_135290705 0.48 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr7_-_27219849 0.46 ENST00000396344.4
HOXA10
homeobox A10
chr10_-_104192405 0.45 ENST00000369937.4
CUEDC2
CUE domain containing 2
chr4_-_157892498 0.44 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr11_-_76155700 0.44 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr5_-_175815565 0.43 ENST00000509257.1
ENST00000507413.1
ENST00000510123.1
NOP16
NOP16 nucleolar protein
chr12_-_23737534 0.43 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr16_+_19222479 0.43 ENST00000568433.1
SYT17
synaptotagmin XVII
chr1_+_223101757 0.43 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr4_-_157892167 0.42 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr2_-_71357344 0.42 ENST00000494660.2
ENST00000244217.5
ENST00000486135.1
MCEE
methylmalonyl CoA epimerase
chr7_+_137761199 0.41 ENST00000411726.2
AKR1D1
aldo-keto reductase family 1, member D1
chr20_+_57875758 0.40 ENST00000395654.3
EDN3
endothelin 3
chr17_+_59529743 0.40 ENST00000589003.1
ENST00000393853.4
TBX4
T-box 4
chr17_-_56065484 0.39 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr5_+_54455946 0.39 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr1_-_205419053 0.39 ENST00000367154.1
LEMD1
LEM domain containing 1
chr4_-_65275162 0.39 ENST00000381210.3
ENST00000507440.1
TECRL
trans-2,3-enoyl-CoA reductase-like
chr3_+_155838337 0.38 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_-_11907829 0.38 ENST00000376480.3
NPPA
natriuretic peptide A
chr10_+_114709999 0.37 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr1_-_109935819 0.36 ENST00000538502.1
SORT1
sortilin 1
chr3_-_79068138 0.36 ENST00000495273.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_+_62417957 0.34 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chr17_+_48611853 0.34 ENST00000507709.1
ENST00000515126.1
ENST00000507467.1
EPN3
epsin 3
chr5_+_140797296 0.33 ENST00000398594.2
PCDHGB7
protocadherin gamma subfamily B, 7
chr2_-_233641265 0.33 ENST00000438786.1
ENST00000409779.1
ENST00000233826.3
KCNJ13
potassium inwardly-rectifying channel, subfamily J, member 13
chr14_-_23762777 0.33 ENST00000431326.2
HOMEZ
homeobox and leucine zipper encoding
chr4_-_157892055 0.33 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr17_-_56065540 0.32 ENST00000583932.1
VEZF1
vascular endothelial zinc finger 1
chr4_-_109684120 0.32 ENST00000512646.1
ENST00000411864.2
ENST00000296486.3
ENST00000510706.1
ETNPPL
ethanolamine-phosphate phospho-lyase
chr3_-_134093738 0.31 ENST00000506107.1
AMOTL2
angiomotin like 2
chr19_+_50003781 0.30 ENST00000602157.1
hsa-mir-150
hsa-mir-150
chr7_-_25702558 0.30 ENST00000423689.2
AC003090.1
AC003090.1
chrX_-_47004437 0.30 ENST00000276062.8
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr15_+_43885799 0.30 ENST00000449946.1
ENST00000417289.1
CKMT1B
creatine kinase, mitochondrial 1B
chrX_+_69488155 0.29 ENST00000374495.3
ARR3
arrestin 3, retinal (X-arrestin)
chr12_+_9067123 0.29 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr11_-_75921780 0.28 ENST00000529461.1
WNT11
wingless-type MMTV integration site family, member 11
chr18_+_46065483 0.28 ENST00000382998.4
CTIF
CBP80/20-dependent translation initiation factor
chr16_+_53242350 0.27 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr10_-_61900762 0.27 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrX_+_54835493 0.27 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr14_+_62037287 0.27 ENST00000556569.1
RP11-47I22.3
Uncharacterized protein
chr11_-_6677018 0.27 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr1_-_54303934 0.27 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr2_+_48796120 0.26 ENST00000394754.1
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr21_-_35284635 0.26 ENST00000429238.1
AP000304.12
AP000304.12
chrX_+_41306575 0.25 ENST00000342595.2
ENST00000378220.1
NYX
nyctalopin
chr13_-_72440901 0.25 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr5_+_140734570 0.24 ENST00000571252.1
PCDHGA4
protocadherin gamma subfamily A, 4
chr18_+_46065570 0.24 ENST00000591412.1
CTIF
CBP80/20-dependent translation initiation factor
chr6_+_64281906 0.23 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_201936458 0.23 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chrX_-_47004878 0.23 ENST00000377811.3
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr8_+_75015699 0.23 ENST00000522498.1
RP11-6I2.4
RP11-6I2.4
chr8_+_55466915 0.23 ENST00000522711.2
RP11-53M11.3
RP11-53M11.3
chrX_+_69488174 0.23 ENST00000480877.2
ENST00000307959.8
ARR3
arrestin 3, retinal (X-arrestin)
chr1_+_200860122 0.23 ENST00000532631.1
ENST00000451872.2
C1orf106
chromosome 1 open reading frame 106
chr4_-_146859623 0.22 ENST00000379448.4
ENST00000513320.1
ZNF827
zinc finger protein 827
chr20_+_57875457 0.22 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chrX_-_10588459 0.22 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr4_+_95972822 0.22 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr18_+_46065393 0.22 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr10_+_114710211 0.21 ENST00000349937.2
ENST00000369397.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr14_-_21502944 0.21 ENST00000382951.3
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr18_-_24445729 0.21 ENST00000383168.4
AQP4
aquaporin 4
chr2_+_201936707 0.21 ENST00000433898.1
ENST00000454214.1
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr12_+_80603233 0.20 ENST00000547103.1
ENST00000458043.2
OTOGL
otogelin-like
chr5_+_102201509 0.20 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr15_-_90294523 0.20 ENST00000300057.4
MESP1
mesoderm posterior 1 homolog (mouse)
chrX_+_15525426 0.20 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr12_-_130529501 0.20 ENST00000561864.1
ENST00000567788.1
RP11-474D1.4
RP11-474D1.3
RP11-474D1.4
RP11-474D1.3
chr3_-_45957534 0.20 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr3_+_57875711 0.19 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr6_-_112575838 0.19 ENST00000455073.1
LAMA4
laminin, alpha 4
chr8_-_142012169 0.19 ENST00000517453.1
PTK2
protein tyrosine kinase 2
chr1_+_154244987 0.18 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr7_+_27282319 0.18 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr10_+_114133773 0.18 ENST00000354655.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_80275621 0.17 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr1_+_180199393 0.17 ENST00000263726.2
LHX4
LIM homeobox 4
chr1_+_147013182 0.17 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr1_-_54304212 0.17 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chrX_+_47004599 0.16 ENST00000329236.7
RBM10
RNA binding motif protein 10
chr9_+_125796806 0.16 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr1_-_65533390 0.16 ENST00000448344.1
RP4-535B20.1
RP4-535B20.1
chr14_+_32798462 0.16 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr3_-_45957088 0.15 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr15_+_93447675 0.15 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.6 1.8 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.5 1.6 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.5 1.6 GO:1903625 negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.5 1.5 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.4 1.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.3 1.0 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.3 1.0 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.3 1.5 GO:0030573 bile acid catabolic process(GO:0030573)
0.3 2.0 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.3 1.7 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.3 0.8 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.7 GO:0100012 regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.2 2.0 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 1.4 GO:0014826 cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826)
0.2 1.0 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.2 0.6 GO:0070632 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.2 0.2 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 0.5 GO:1990697 protein depalmitoleylation(GO:1990697)
0.2 0.9 GO:2000051 Wnt receptor catabolic process(GO:0038018) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.2 2.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 0.5 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.2 2.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 0.6 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.6 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.3 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 1.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 1.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.7 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 0.3 GO:0003192 mitral valve formation(GO:0003192)
0.1 1.8 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1 0.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.5 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.4 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.1 0.3 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.4 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 4.4 GO:0010107 potassium ion import(GO:0010107)
0.1 1.0 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 0.5 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.2 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.2 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
0.1 0.3 GO:0018032 protein amidation(GO:0018032)
0.1 0.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.0 0.3 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.8 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 0.8 GO:0060539 diaphragm development(GO:0060539)
0.0 0.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 1.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 1.1 GO:0060065 uterus development(GO:0060065)
0.0 0.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.4 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 1.1 GO:0001502 cartilage condensation(GO:0001502)
0.0 5.5 GO:0001942 hair follicle development(GO:0001942)
0.0 2.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.3 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 1.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 2.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.8 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.5 GO:0072189 ureter development(GO:0072189)
0.0 0.7 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 2.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 1.0 GO:0045494 retinol metabolic process(GO:0042572) photoreceptor cell maintenance(GO:0045494)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 2.9 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 1.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.0 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 1.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.5 GO:0050953 visual perception(GO:0007601) sensory perception of light stimulus(GO:0050953)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.6 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.2 2.2 GO:0016013 syntrophin complex(GO:0016013)
0.1 1.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 3.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 4.4 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.0 GO:0045179 apical cortex(GO:0045179)
0.1 1.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.7 GO:0000800 lateral element(GO:0000800)
0.1 0.7 GO:0043203 axon hillock(GO:0043203)
0.0 2.6 GO:0005605 basal lamina(GO:0005605)
0.0 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.7 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 2.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 3.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 5.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.3 1.0 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.3 1.5 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.3 2.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 1.4 GO:0031708 endothelin B receptor binding(GO:0031708)
0.3 0.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 2.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.2 1.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 1.1 GO:0030492 hemoglobin binding(GO:0030492)
0.2 0.5 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.2 1.7 GO:0004111 creatine kinase activity(GO:0004111)
0.2 4.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 7.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.5 GO:0002046 opsin binding(GO:0002046)
0.1 0.3 GO:1990175 EH domain binding(GO:1990175)
0.1 1.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.5 GO:0050436 microfibril binding(GO:0050436)
0.1 2.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 2.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.6 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.4 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 3.1 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 2.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.3 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 1.0 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 1.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.5 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.2 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.4 GO:0070402 NADPH binding(GO:0070402)
0.0 4.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.4 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 1.0 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 2.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 2.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.4 PID ENDOTHELIN PATHWAY Endothelins
0.0 5.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 1.5 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 4.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 3.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.8 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 2.3 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines