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Illumina Body Map 2: averaged replicates
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Results for TFAP2B
Z-value: 1.90
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Transcription factors associated with TFAP2B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2B | hg19_v2_chr6_+_50786414_50786439 | 0.15 | 4.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 5.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 5.2 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 1.1 | 4.2 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.1 | 3.9 | GO:0008211 | glucocorticoid metabolic process(GO:0008211) |
| 0.0 | 3.9 | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle(GO:0007091) |
| 0.0 | 3.9 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 3.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 3.6 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.6 | 3.5 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 4.7 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 4.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 4.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 4.0 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.0 | 3.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 3.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 3.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.9 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 2.6 | GO:0005905 | clathrin-coated pit(GO:0005905) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.8 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.6 | 6.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.6 | 5.2 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.0 | 4.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.1 | 4.2 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.1 | 3.8 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 3.5 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.2 | 3.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.3 | 2.8 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 5.4 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 4.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 3.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.9 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 3.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 3.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 3.0 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 2.2 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.4 | 9.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 9.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 7.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 5.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 3.5 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 3.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 2.6 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 2.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |