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Illumina Body Map 2: averaged replicates
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Results for THRA_RXRB
Z-value: 2.27
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Transcription factors associated with THRA_RXRB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RXRB | hg19_v2_chr6_-_33168391_33168465 | 0.23 | 2.0e-01 | Click! |
| THRA | hg19_v2_chr17_+_38219063_38219154 | 0.08 | 6.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of THRA_RXRB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 18.9 | GO:0060629 | regulation of homologous chromosome segregation(GO:0060629) |
| 0.1 | 13.2 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.1 | 12.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.2 | 7.2 | GO:0042335 | cuticle development(GO:0042335) |
| 0.4 | 6.5 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.0 | 5.1 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 4.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 1.0 | 4.2 | GO:0060032 | notochord regression(GO:0060032) |
| 0.2 | 3.9 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 3.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.9 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.1 | 10.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 9.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 7.7 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 5.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 5.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 5.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 4.2 | GO:0097546 | ciliary base(GO:0097546) |
| 0.1 | 3.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 3.7 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 7.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 6.5 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 6.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 5.8 | GO:0004518 | nuclease activity(GO:0004518) |
| 0.0 | 5.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.4 | 5.6 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 3.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 3.5 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.1 | 3.3 | GO:0005003 | ephrin receptor activity(GO:0005003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 4.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 3.2 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.8 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 4.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 4.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 3.6 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 2.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 2.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.3 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 2.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.0 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |