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Illumina Body Map 2: averaged replicates

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Results for THRA_RXRB

Z-value: 2.27

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Transcription factors associated with THRA_RXRB

Gene Symbol Gene ID Gene Info
THRA
ENSG00000126351.8 thyroid hormone receptor alpha
RXRB
ENSG00000204231.6 retinoid X receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RXRBhg19_v2_chr6_-_33168391_331684650.232.0e-01Click!
THRAhg19_v2_chr17_+_38219063_382191540.086.5e-01Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_150693318 11.49 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMAD1
HORMA domain containing 1
chr1_-_150693305 7.36 ENST00000368987.1
HORMAD1
HORMA domain containing 1
chr1_+_178482212 4.81 ENST00000319416.2
ENST00000258298.2
ENST00000367643.3
ENST00000367642.3
TEX35
testis expressed 35
chr11_-_26593677 4.58 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr12_+_57854274 4.15 ENST00000528432.1
GLI1
GLI family zinc finger 1
chr7_+_128431444 3.92 ENST00000459946.1
ENST00000378685.4
ENST00000464832.1
ENST00000472049.1
ENST00000488925.1
CCDC136
coiled-coil domain containing 136
chr11_-_123756334 3.82 ENST00000528595.1
ENST00000375026.2
TMEM225
transmembrane protein 225
chr19_-_55874611 3.80 ENST00000424985.3
FAM71E2
family with sequence similarity 71, member E2
chrX_-_70326455 3.77 ENST00000374251.5
CXorf65
chromosome X open reading frame 65
chr15_+_45422131 3.73 ENST00000321429.4
DUOX1
dual oxidase 1
chr22_+_23264766 3.68 ENST00000390331.2
IGLC7
immunoglobulin lambda constant 7
chr5_+_162887556 3.63 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR
hyaluronan-mediated motility receptor (RHAMM)
chr12_-_52995291 3.57 ENST00000293745.2
ENST00000354310.4
KRT72
keratin 72
chrX_-_30327495 3.53 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr20_-_13971255 3.50 ENST00000284951.5
ENST00000378072.5
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr15_+_45422178 3.47 ENST00000389037.3
ENST00000558322.1
DUOX1
dual oxidase 1
chr16_+_4784273 3.43 ENST00000299320.5
ENST00000586724.1
C16orf71
chromosome 16 open reading frame 71
chr7_+_100187196 3.43 ENST00000468962.1
ENST00000427939.2
FBXO24
F-box protein 24
chr12_+_7072354 3.13 ENST00000537269.1
U47924.27
U47924.27
chr15_-_45422056 3.11 ENST00000267803.4
ENST00000559014.1
ENST00000558851.1
ENST00000559988.1
ENST00000558996.1
ENST00000558422.1
ENST00000559226.1
ENST00000558326.1
ENST00000558377.1
ENST00000559644.1
DUOXA1
dual oxidase maturation factor 1
chr19_-_35719609 3.04 ENST00000324675.3
FAM187B
family with sequence similarity 187, member B
chr19_+_49109990 3.02 ENST00000321762.1
SPACA4
sperm acrosome associated 4
chr16_+_4784458 2.98 ENST00000590191.1
C16orf71
chromosome 16 open reading frame 71
chr22_+_51176624 2.94 ENST00000216139.5
ENST00000529621.1
ACR
acrosin
chr1_+_160147176 2.78 ENST00000470705.1
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr19_-_52227221 2.71 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr20_+_32250079 2.68 ENST00000375222.3
C20orf144
chromosome 20 open reading frame 144
chr16_-_11367452 2.66 ENST00000327157.2
PRM3
protamine 3
chr1_-_38218577 2.61 ENST00000540011.1
EPHA10
EPH receptor A10
chr20_+_32254286 2.60 ENST00000330271.4
ACTL10
actin-like 10
chr2_-_55459485 2.50 ENST00000451916.1
CLHC1
clathrin heavy chain linker domain containing 1
chr9_-_127358087 2.48 ENST00000475178.1
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr1_+_212797789 2.47 ENST00000294829.3
FAM71A
family with sequence similarity 71, member A
chr13_+_113030625 2.44 ENST00000283550.3
SPACA7
sperm acrosome associated 7
chr2_+_232457569 2.42 ENST00000313965.2
C2orf57
chromosome 2 open reading frame 57
chr20_-_31592113 2.41 ENST00000420875.1
ENST00000375519.2
ENST00000375523.3
ENST00000356173.3
SUN5
Sad1 and UNC84 domain containing 5
chr16_-_58328923 2.38 ENST00000567164.1
ENST00000219301.4
ENST00000569727.1
PRSS54
protease, serine, 54
chr22_-_29137771 2.36 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr1_+_20396649 2.31 ENST00000375108.3
PLA2G5
phospholipase A2, group V
chr3_+_137490748 2.30 ENST00000478772.1
RP11-2A4.3
RP11-2A4.3
chr22_+_22764088 2.30 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr7_+_73245193 2.28 ENST00000340958.2
CLDN4
claudin 4
chr18_-_53804580 2.28 ENST00000590484.1
ENST00000589293.1
ENST00000587904.1
ENST00000591974.1
RP11-456O19.4
RP11-456O19.4
chr16_-_58328884 2.28 ENST00000569079.1
PRSS54
protease, serine, 54
chr7_-_121944491 2.27 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr11_-_5531215 2.18 ENST00000311659.4
UBQLN3
ubiquilin 3
chr11_+_66624527 2.18 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr16_-_72206034 2.16 ENST00000537465.1
ENST00000237353.10
PMFBP1
polyamine modulated factor 1 binding protein 1
chr8_+_103563792 2.13 ENST00000285402.3
ODF1
outer dense fiber of sperm tails 1
chr14_-_106054659 2.11 ENST00000390539.2
IGHA2
immunoglobulin heavy constant alpha 2 (A2m marker)
chr2_-_55459437 2.10 ENST00000401408.1
CLHC1
clathrin heavy chain linker domain containing 1
chr12_-_5352315 2.10 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr22_+_22697537 2.04 ENST00000427632.2
IGLV9-49
immunoglobulin lambda variable 9-49
chr9_+_140145713 1.99 ENST00000388931.3
ENST00000412566.1
C9orf173
chromosome 9 open reading frame 173
chr1_+_178482262 1.96 ENST00000367641.3
ENST00000367639.1
TEX35
testis expressed 35
chr16_-_58328870 1.96 ENST00000543437.1
PRSS54
protease, serine, 54
chr9_+_35042205 1.95 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr2_+_230787213 1.91 ENST00000409992.1
FBXO36
F-box protein 36
chr12_+_122018697 1.88 ENST00000541574.1
RP13-941N14.1
RP13-941N14.1
chr3_-_126277796 1.87 ENST00000318225.2
C3orf22
chromosome 3 open reading frame 22
chr22_+_22681656 1.86 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr2_+_220491973 1.85 ENST00000358055.3
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr7_+_120969045 1.76 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr11_-_5531159 1.75 ENST00000445998.1
UBQLN3
ubiquilin 3
chr2_+_231860830 1.72 ENST00000424440.1
ENST00000452881.1
ENST00000433428.2
ENST00000455816.1
ENST00000440792.1
ENST00000423134.1
SPATA3
spermatogenesis associated 3
chr3_+_10068095 1.72 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr1_-_203144941 1.69 ENST00000255416.4
MYBPH
myosin binding protein H
chr1_+_32827759 1.68 ENST00000373534.3
TSSK3
testis-specific serine kinase 3
chr20_+_43343886 1.62 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr2_+_230787201 1.62 ENST00000283946.3
FBXO36
F-box protein 36
chr22_+_23165153 1.61 ENST00000390317.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr22_+_23213658 1.60 ENST00000390318.2
IGLV4-3
immunoglobulin lambda variable 4-3
chr1_+_96457545 1.60 ENST00000413825.2
RP11-147C23.1
Uncharacterized protein
chr17_+_58499844 1.60 ENST00000269127.4
C17orf64
chromosome 17 open reading frame 64
chr18_+_19749386 1.59 ENST00000269216.3
GATA6
GATA binding protein 6
chr9_+_36572851 1.59 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
MELK
maternal embryonic leucine zipper kinase
chr22_+_22516550 1.57 ENST00000390284.2
IGLV4-60
immunoglobulin lambda variable 4-60
chr17_+_43922241 1.57 ENST00000329196.5
SPPL2C
signal peptide peptidase like 2C
chr8_-_30706608 1.55 ENST00000256246.2
TEX15
testis expressed 15
chr7_+_26591441 1.52 ENST00000420912.1
ENST00000457000.1
ENST00000430426.1
AC004947.2
AC004947.2
chr2_-_55459294 1.51 ENST00000407122.1
ENST00000406437.2
CLHC1
clathrin heavy chain linker domain containing 1
chr2_-_61389168 1.50 ENST00000607743.1
ENST00000605902.1
RP11-493E12.1
RP11-493E12.1
chr1_+_45212074 1.50 ENST00000372217.1
KIF2C
kinesin family member 2C
chr5_+_71014990 1.50 ENST00000296777.4
CARTPT
CART prepropeptide
chr17_+_60457914 1.48 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3
EF-hand calcium binding domain 3
chr12_+_102514019 1.47 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr2_+_219745020 1.46 ENST00000258411.3
WNT10A
wingless-type MMTV integration site family, member 10A
chr7_+_23749945 1.45 ENST00000354639.3
ENST00000531170.1
ENST00000444333.2
ENST00000428484.1
STK31
serine/threonine kinase 31
chr8_+_145086574 1.42 ENST00000377470.3
ENST00000447830.2
SPATC1
spermatogenesis and centriole associated 1
chr2_-_61389240 1.41 ENST00000606876.1
RP11-493E12.1
RP11-493E12.1
chr22_-_20138302 1.40 ENST00000540078.1
ENST00000439765.2
AC006547.14
uncharacterized protein LOC388849
chr1_+_45212051 1.39 ENST00000372222.3
KIF2C
kinesin family member 2C
chr18_+_61143994 1.38 ENST00000382771.4
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr5_+_118965244 1.38 ENST00000515256.1
ENST00000509264.1
FAM170A
family with sequence similarity 170, member A
chr19_+_49866331 1.37 ENST00000597873.1
DKKL1
dickkopf-like 1
chr22_+_23077065 1.36 ENST00000390310.2
IGLV2-18
immunoglobulin lambda variable 2-18
chr9_+_139874683 1.35 ENST00000444903.1
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr9_-_88874519 1.35 ENST00000376001.3
ENST00000339137.3
C9orf153
chromosome 9 open reading frame 153
chrX_+_23928500 1.34 ENST00000435707.1
CXorf58
chromosome X open reading frame 58
chr7_+_23749767 1.32 ENST00000355870.3
STK31
serine/threonine kinase 31
chr22_+_22453093 1.32 ENST00000390283.2
IGLV8-61
immunoglobulin lambda variable 8-61
chr1_+_241815577 1.32 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chrX_-_152989798 1.31 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
BCAP31
B-cell receptor-associated protein 31
chr22_-_17073700 1.30 ENST00000359963.3
CCT8L2
chaperonin containing TCP1, subunit 8 (theta)-like 2
chr17_+_48046538 1.30 ENST00000240306.3
DLX4
distal-less homeobox 4
chrX_+_13587712 1.27 ENST00000361306.1
ENST00000380602.3
EGFL6
EGF-like-domain, multiple 6
chr5_+_170288856 1.25 ENST00000523189.1
RANBP17
RAN binding protein 17
chr8_-_99955042 1.24 ENST00000519420.1
STK3
serine/threonine kinase 3
chr7_+_23749894 1.24 ENST00000433467.2
STK31
serine/threonine kinase 31
chr12_+_48876275 1.24 ENST00000314014.2
C12orf54
chromosome 12 open reading frame 54
chr2_+_220492116 1.24 ENST00000373760.2
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr22_-_29138386 1.23 ENST00000544772.1
CHEK2
checkpoint kinase 2
chr2_-_231860596 1.22 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr14_-_89021077 1.21 ENST00000556564.1
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr14_-_106174960 1.21 ENST00000390547.2
IGHA1
immunoglobulin heavy constant alpha 1
chr14_+_27342334 1.18 ENST00000548170.1
ENST00000552926.1
RP11-384J4.1
RP11-384J4.1
chr3_+_45067659 1.18 ENST00000296130.4
CLEC3B
C-type lectin domain family 3, member B
chr1_+_55107449 1.18 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
MROH7
maestro heat-like repeat family member 7
chr2_+_197577841 1.16 ENST00000409270.1
CCDC150
coiled-coil domain containing 150
chr22_+_23134974 1.11 ENST00000390314.2
IGLV2-11
immunoglobulin lambda variable 2-11
chr22_+_22569155 1.10 ENST00000390287.2
IGLV10-54
immunoglobulin lambda variable 10-54
chr12_+_53817633 1.09 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
AMHR2
anti-Mullerian hormone receptor, type II
chr8_+_98881268 1.09 ENST00000254898.5
ENST00000524308.1
ENST00000522025.2
MATN2
matrilin 2
chr1_-_32827682 1.08 ENST00000432622.1
FAM229A
family with sequence similarity 229, member A
chr15_-_31393910 1.07 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr3_+_14989186 1.06 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr22_+_22712087 1.06 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr4_+_20255123 1.05 ENST00000504154.1
ENST00000273739.5
SLIT2
slit homolog 2 (Drosophila)
chr12_+_52626898 1.03 ENST00000331817.5
KRT7
keratin 7
chr18_-_19748379 1.03 ENST00000579431.1
GATA6-AS1
GATA6 antisense RNA 1 (head to head)
chr12_+_102513950 1.03 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr13_+_113030658 1.03 ENST00000414180.1
ENST00000443541.1
SPACA7
sperm acrosome associated 7
chr12_-_78753496 1.01 ENST00000548512.1
RP11-38F22.1
RP11-38F22.1
chr22_+_23243156 1.01 ENST00000390323.2
IGLC2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr3_-_51813009 1.00 ENST00000398780.3
IQCF6
IQ motif containing F6
chr1_-_7913089 1.00 ENST00000361696.5
UTS2
urotensin 2
chr22_+_23040274 0.99 ENST00000390306.2
IGLV2-23
immunoglobulin lambda variable 2-23
chr2_+_87565634 0.99 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr4_+_48343339 0.98 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr3_-_49726104 0.96 ENST00000383728.3
ENST00000545762.1
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr12_+_106994905 0.95 ENST00000357881.4
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr15_-_83316254 0.94 ENST00000567678.1
ENST00000450751.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr7_+_23749854 0.94 ENST00000456014.2
STK31
serine/threonine kinase 31
chr1_+_196621156 0.91 ENST00000359637.2
CFH
complement factor H
chr2_+_179316163 0.90 ENST00000409117.3
DFNB59
deafness, autosomal recessive 59
chr18_-_19748331 0.89 ENST00000584201.1
GATA6-AS1
GATA6 antisense RNA 1 (head to head)
chrX_+_101380642 0.89 ENST00000372780.1
ENST00000329035.2
TCEAL2
transcription elongation factor A (SII)-like 2
chr12_+_27849378 0.88 ENST00000310791.2
REP15
RAB15 effector protein
chr18_+_61144160 0.87 ENST00000489441.1
ENST00000424602.1
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr6_+_21593972 0.87 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr11_-_3240043 0.86 ENST00000332314.3
MRGPRG
MAS-related GPR, member G
chr1_+_55107489 0.86 ENST00000395690.2
MROH7
maestro heat-like repeat family member 7
chr22_+_22676808 0.84 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr7_+_23749822 0.84 ENST00000422637.1
STK31
serine/threonine kinase 31
chr1_-_103574024 0.83 ENST00000512756.1
ENST00000370096.3
ENST00000358392.2
ENST00000353414.4
COL11A1
collagen, type XI, alpha 1
chr4_+_93225550 0.83 ENST00000282020.4
GRID2
glutamate receptor, ionotropic, delta 2
chr17_+_37894179 0.82 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr14_-_25078864 0.82 ENST00000216338.4
ENST00000557220.2
ENST00000382548.4
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr11_+_1860200 0.81 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr2_-_90538397 0.80 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr14_+_77292715 0.79 ENST00000393774.3
ENST00000555189.1
ENST00000450042.2
C14orf166B
chromosome 14 open reading frame 166B
chr17_-_58499698 0.79 ENST00000590297.1
USP32
ubiquitin specific peptidase 32
chr5_-_145483932 0.79 ENST00000311450.4
PLAC8L1
PLAC8-like 1
chr16_+_85942594 0.78 ENST00000566369.1
IRF8
interferon regulatory factor 8
chr1_-_149900122 0.77 ENST00000271628.8
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr14_+_88852059 0.77 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr7_+_128312346 0.75 ENST00000480462.1
ENST00000378704.3
ENST00000477515.1
FAM71F2
family with sequence similarity 71, member F2
chr16_+_67700673 0.75 ENST00000403458.4
ENST00000602365.1
C16orf86
chromosome 16 open reading frame 86
chr19_+_41117770 0.75 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr1_+_152881014 0.74 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr14_-_101351184 0.73 ENST00000534062.1
RTL1
retrotransposon-like 1
chr3_+_172361483 0.73 ENST00000598405.1
AC007919.2
HCG1787166; PRO1163; Uncharacterized protein
chr7_+_76751926 0.73 ENST00000285871.4
ENST00000431197.1
CCDC146
coiled-coil domain containing 146
chr10_+_76586348 0.73 ENST00000372724.1
ENST00000287239.4
ENST00000372714.1
KAT6B
K(lysine) acetyltransferase 6B
chr10_+_77056181 0.73 ENST00000526759.1
ENST00000533822.1
ZNF503-AS1
ZNF503 antisense RNA 1
chr1_+_200842083 0.72 ENST00000304244.2
GPR25
G protein-coupled receptor 25
chr3_-_79068594 0.71 ENST00000436010.2
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_-_31782813 0.70 ENST00000375654.4
HSPA1L
heat shock 70kDa protein 1-like
chr12_-_52995179 0.70 ENST00000549979.1
KRT72
keratin 72
chr1_-_38230738 0.70 ENST00000427468.2
ENST00000373048.4
ENST00000319637.6
EPHA10
EPH receptor A10
chr12_-_133812681 0.69 ENST00000545940.1
ANHX
anomalous homeobox
chr11_+_64008525 0.69 ENST00000449942.2
FKBP2
FK506 binding protein 2, 13kDa
chr1_-_242612779 0.68 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr15_-_83316087 0.68 ENST00000568757.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr8_-_144651024 0.68 ENST00000524906.1
ENST00000532862.1
ENST00000534459.1
MROH6
maestro heat-like repeat family member 6
chr12_+_41221794 0.68 ENST00000547849.1
CNTN1
contactin 1
chr22_-_20255212 0.67 ENST00000416372.1
RTN4R
reticulon 4 receptor
chr19_+_45281118 0.67 ENST00000270279.3
ENST00000341505.4
CBLC
Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr19_+_32836499 0.66 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr1_+_196621002 0.66 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr2_+_39117010 0.66 ENST00000409978.1
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr3_+_138153451 0.64 ENST00000389567.4
ENST00000289135.4
ESYT3
extended synaptotagmin-like protein 3
chr19_+_39989535 0.64 ENST00000356433.5
DLL3
delta-like 3 (Drosophila)
chr17_+_37894570 0.61 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr9_+_133259836 0.60 ENST00000455439.2
HMCN2
hemicentin 2
chr17_-_15496722 0.59 ENST00000472534.1
CDRT1
CMT1A duplicated region transcript 1
chr2_-_49381646 0.58 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr12_-_95510743 0.57 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr16_+_28875126 0.57 ENST00000359285.5
ENST00000538342.1
SH2B1
SH2B adaptor protein 1
chr12_-_50790267 0.56 ENST00000327337.5
ENST00000543111.1
FAM186A
family with sequence similarity 186, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 18.9 GO:0060629 regulation of homologous chromosome segregation(GO:0060629)
1.2 7.2 GO:0042335 cuticle development(GO:0042335)
1.2 3.6 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.0 4.2 GO:0060032 notochord regression(GO:0060032)
0.7 2.7 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.6 2.3 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.5 1.6 GO:0007493 endodermal cell fate determination(GO:0007493)
0.5 1.5 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.4 3.1 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.4 6.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.4 2.9 GO:0007341 penetration of zona pellucida(GO:0007341)
0.4 1.8 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.4 1.8 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.3 2.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.0 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.3 3.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.3 1.1 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.2 2.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 0.9 GO:0038194 thyroid-stimulating hormone signaling pathway(GO:0038194) cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.2 0.9 GO:0035905 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.2 0.8 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.2 1.2 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.2 3.5 GO:0030238 male sex determination(GO:0030238)
0.2 3.9 GO:0001675 acrosome assembly(GO:0001675)
0.2 1.7 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.2 1.3 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.2 1.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.2 2.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2 0.5 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.2 0.2 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.2 1.1 GO:0014826 cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826)
0.2 0.5 GO:1900211 mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212)
0.1 0.7 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 1.1 GO:0007386 compartment pattern specification(GO:0007386)
0.1 2.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.5 GO:2001302 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.1 0.9 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 3.1 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 1.4 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1 1.2 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.1 2.6 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 2.4 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.8 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.5 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.1 13.2 GO:0030449 regulation of complement activation(GO:0030449)
0.1 1.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.2 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 1.1 GO:0048733 sebaceous gland development(GO:0048733)
0.1 2.3 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.2 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.1 1.6 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 0.4 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 0.2 GO:0035508 positive regulation of myosin-light-chain-phosphatase activity(GO:0035508)
0.1 0.3 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.6 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.1 1.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 12.3 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.1 GO:0046548 retinal rod cell development(GO:0046548)
0.1 1.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 1.3 GO:0042832 defense response to protozoan(GO:0042832)
0.1 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.2 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.2 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) ganglion morphogenesis(GO:0061552) blood vessel endothelial cell fate specification(GO:0097101) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.2 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 0.7 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 2.2 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.0 0.2 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 4.6 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 1.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 3.2 GO:0030317 sperm motility(GO:0030317)
0.0 0.5 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.0 1.4 GO:0042749 regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.9 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.8 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.2 GO:0032796 uropod organization(GO:0032796)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.5 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 5.1 GO:0070268 cornification(GO:0070268)
0.0 3.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.1 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.0 0.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.6 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.8 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0042026 protein refolding(GO:0042026)
0.0 0.1 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 2.0 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.3 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.2 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.8 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0036376 sodium ion export from cell(GO:0036376) regulation of sodium ion export(GO:1903273) positive regulation of sodium ion export(GO:1903275) regulation of sodium ion export from cell(GO:1903276) positive regulation of sodium ion export from cell(GO:1903278)
0.0 0.7 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.0 0.2 GO:0002467 germinal center formation(GO:0002467)
0.0 0.3 GO:0016559 peroxisome fission(GO:0016559)
0.0 1.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 2.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.1 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 1.1 GO:0006739 NADP metabolic process(GO:0006739)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.3 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.9 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.0 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.0 0.8 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 0.0 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 1.1 GO:0008347 glial cell migration(GO:0008347)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.6 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 1.0 GO:0045840 positive regulation of mitotic nuclear division(GO:0045840)
0.0 0.7 GO:0033572 transferrin transport(GO:0033572)
0.0 0.0 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.1 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.1 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0071745 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
1.0 2.9 GO:0043159 acrosomal matrix(GO:0043159)
0.3 18.9 GO:0000795 synaptonemal complex(GO:0000795)
0.3 1.6 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.3 3.5 GO:0042788 polysomal ribosome(GO:0042788)
0.3 1.1 GO:0035841 new growing cell tip(GO:0035841)
0.2 1.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.2 7.7 GO:0002080 acrosomal membrane(GO:0002080)
0.2 1.2 GO:0001652 granular component(GO:0001652)
0.1 2.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 2.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 10.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.2 GO:0097546 ciliary base(GO:0097546)
0.1 2.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 3.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.3 GO:1990234 transferase complex(GO:1990234)
0.1 5.6 GO:0045095 keratin filament(GO:0045095)
0.1 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 2.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 1.9 GO:0032982 myosin filament(GO:0032982)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.7 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.3 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.2 GO:0045160 myosin I complex(GO:0045160)
0.0 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 2.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 5.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.7 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.5 GO:0030018 Z disc(GO:0030018)
0.0 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 9.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.0 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0097440 apical dendrite(GO:0097440)
0.0 0.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 5.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.6 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0004040 amidase activity(GO:0004040)
0.4 2.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.4 6.5 GO:0003796 lysozyme activity(GO:0003796)
0.4 5.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.4 1.1 GO:0052856 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.3 1.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 1.1 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.3 1.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.3 2.9 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 0.7 GO:0038131 neuregulin receptor activity(GO:0038131)
0.2 1.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 0.6 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.2 2.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.5 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.1 1.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.9 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 0.5 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977)
0.1 2.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 7.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 3.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 3.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 3.5 GO:0000217 DNA secondary structure binding(GO:0000217)
0.1 18.4 GO:0003823 antigen binding(GO:0003823)
0.1 0.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 3.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 2.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.2 GO:0070984 SET domain binding(GO:0070984)
0.1 1.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 1.9 GO:0043495 protein anchor(GO:0043495)
0.1 3.2 GO:0005109 frizzled binding(GO:0005109)
0.1 0.8 GO:0031014 troponin T binding(GO:0031014)
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 1.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.5 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.5 GO:0050699 WW domain binding(GO:0050699)
0.0 1.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 1.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 1.1 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.7 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 5.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.0 2.5 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 6.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.8 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.0 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.0 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 5.8 GO:0004518 nuclease activity(GO:0004518)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 2.7 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.0 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 5.3 PID ATM PATHWAY ATM pathway
0.0 1.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.4 PID NOTCH PATHWAY Notch signaling pathway
0.0 3.1 PID AURORA B PATHWAY Aurora B signaling
0.0 3.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID IL27 PATHWAY IL27-mediated signaling events
0.0 5.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID FOXO PATHWAY FoxO family signaling
0.0 1.1 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.5 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 4.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 3.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 2.0 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 4.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.9 REACTOME KINESINS Genes involved in Kinesins
0.0 2.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 2.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 4.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 2.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production