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Illumina Body Map 2: averaged replicates

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Results for THRB

Z-value: 1.19

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536222_24536249-0.826.5e-09Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_22180536 4.52 ENST00000390424.2
TRAV2
T cell receptor alpha variable 2
chr19_+_55085248 3.46 ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
LILRA2
LILRB1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr17_-_73840415 3.42 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr20_+_37434329 3.24 ENST00000299824.1
ENST00000373331.2
PPP1R16B
protein phosphatase 1, regulatory subunit 16B
chr17_-_73840614 3.12 ENST00000586108.1
UNC13D
unc-13 homolog D (C. elegans)
chr11_-_47400062 3.11 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr7_-_38394118 3.08 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr11_-_47399942 3.00 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47400032 2.85 ENST00000533968.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47400078 2.71 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr17_-_73840774 2.65 ENST00000207549.4
UNC13D
unc-13 homolog D (C. elegans)
chr17_-_73839792 2.35 ENST00000590762.1
UNC13D
unc-13 homolog D (C. elegans)
chr6_+_42883727 2.19 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA
pre T-cell antigen receptor alpha
chr8_-_131028782 2.16 ENST00000519020.1
FAM49B
family with sequence similarity 49, member B
chr8_+_28174649 2.01 ENST00000301908.3
PNOC
prepronociceptin
chr16_+_72088376 1.98 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr8_+_28174496 1.77 ENST00000518479.1
PNOC
prepronociceptin
chr2_-_73869508 1.46 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr9_-_139268068 1.41 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9
caspase recruitment domain family, member 9
chr11_+_71934962 1.26 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr8_-_124037890 1.26 ENST00000519018.1
ENST00000523036.1
DERL1
derlin 1
chr11_+_5617952 1.22 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chrX_-_1511617 1.07 ENST00000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chrY_-_1461617 1.03 ENSTR0000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr2_-_74692473 0.98 ENST00000535045.1
ENST00000409065.1
ENST00000414701.1
ENST00000448666.1
ENST00000233616.4
ENST00000452063.2
MOGS
mannosyl-oligosaccharide glucosidase
chr6_+_77484663 0.98 ENST00000607287.1
RP11-354K4.2
RP11-354K4.2
chr12_+_54378849 0.92 ENST00000515593.1
HOXC10
homeobox C10
chr11_+_73498973 0.84 ENST00000537007.1
MRPL48
mitochondrial ribosomal protein L48
chr13_+_27844464 0.78 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr1_-_154164534 0.72 ENST00000271850.7
ENST00000368530.2
TPM3
tropomyosin 3
chr1_+_161190160 0.71 ENST00000594609.1
AL590714.1
Uncharacterized protein
chr14_+_75761099 0.71 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5
RP11-293M10.5
chr15_-_101084446 0.68 ENST00000538112.2
ENST00000559639.1
ENST00000558884.2
CERS3
ceramide synthase 3
chr10_+_60145155 0.67 ENST00000373895.3
TFAM
transcription factor A, mitochondrial
chr11_+_73498898 0.66 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr17_+_1646130 0.64 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr16_-_69368774 0.62 ENST00000562949.1
RP11-343C2.12
Conserved oligomeric Golgi complex subunit 8
chr12_+_54378923 0.50 ENST00000303460.4
HOXC10
homeobox C10
chr21_-_37914898 0.49 ENST00000399136.1
CLDN14
claudin 14
chr1_+_77997785 0.49 ENST00000478255.1
AK5
adenylate kinase 5
chr11_-_18747727 0.38 ENST00000513874.1
IGSF22
immunoglobulin superfamily, member 22
chr19_-_52643157 0.38 ENST00000597013.1
ENST00000600228.1
ENST00000596290.1
ZNF616
zinc finger protein 616
chr3_+_172361483 0.32 ENST00000598405.1
AC007919.2
HCG1787166; PRO1163; Uncharacterized protein
chr11_-_64014379 0.30 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_207224307 0.28 ENST00000315927.4
YOD1
YOD1 deubiquitinase
chr22_+_19938419 0.25 ENST00000412786.1
COMT
catechol-O-methyltransferase
chr18_-_47808050 0.24 ENST00000590208.1
MBD1
methyl-CpG binding domain protein 1
chr18_-_47808120 0.24 ENST00000587605.1
ENST00000591416.1
ENST00000382948.5
ENST00000269471.5
ENST00000269468.5
ENST00000347968.3
ENST00000436910.1
ENST00000349085.2
MBD1
methyl-CpG binding domain protein 1
chr15_-_35838348 0.19 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
DPH6
diphthamine biosynthesis 6
chr8_+_19674651 0.18 ENST00000397977.3
INTS10
integrator complex subunit 10
chr5_+_131746575 0.18 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr6_+_151042224 0.17 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr20_+_388679 0.11 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_21810765 0.06 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr20_+_388791 0.05 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr13_-_24007815 0.03 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr18_-_47807829 0.02 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
MBD1
methyl-CpG binding domain protein 1
chr8_-_100905850 0.01 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
COX6C
cytochrome c oxidase subunit VIc
chr2_-_9563216 0.01 ENST00000467606.1
ENST00000494563.1
ENST00000460001.1
ITGB1BP1
integrin beta 1 binding protein 1
chr2_-_9563469 0.00 ENST00000484735.1
ENST00000456913.2
ITGB1BP1
integrin beta 1 binding protein 1
chr15_-_101084547 0.00 ENST00000394113.1
CERS3
ceramide synthase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.5 GO:0002432 granuloma formation(GO:0002432)
2.3 11.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
1.1 3.2 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.9 3.5 GO:2001193 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.7 2.1 GO:0052510 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.7 2.0 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.3 2.2 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.2 1.3 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.2 0.7 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 0.5 GO:0006173 dADP biosynthetic process(GO:0006173)
0.1 0.6 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 1.4 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 1.4 GO:0032494 response to peptidoglycan(GO:0032494)
0.1 0.3 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 3.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 4.5 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.8 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 1.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.5 GO:0006749 glutathione metabolic process(GO:0006749)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.5 2.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 1.3 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.1 2.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 11.7 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.8 GO:0043679 axon terminus(GO:0043679)
0.0 2.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 11.7 GO:0051525 NFAT protein binding(GO:0051525)
0.9 3.5 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.5 3.8 GO:0001515 opioid peptide activity(GO:0001515)
0.5 2.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.3 2.0 GO:0030492 hemoglobin binding(GO:0030492)
0.3 2.2 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.2 1.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.7 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 1.3 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.3 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 1.4 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.0 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.5 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 11.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 3.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 11.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 2.2 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 2.1 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 3.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 3.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions