Project
Illumina Body Map 2: averaged replicates
Navigation
Downloads
Results for TLX1_NFIC
Z-value: 2.77
Motif logo
Transcription factors associated with TLX1_NFIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIC | hg19_v2_chr19_+_3359561_3359681 | 0.42 | 1.8e-02 | Click! |
| TLX1 | hg19_v2_chr10_+_102891048_102891078 | -0.05 | 7.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX1_NFIC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 13.9 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.4 | 13.3 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.2 | 13.3 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.5 | 13.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 4.1 | 12.4 | GO:0051466 | positive regulation of corticotropin-releasing hormone secretion(GO:0051466) |
| 0.2 | 12.0 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.2 | 10.6 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.3 | 10.3 | GO:0032060 | bleb assembly(GO:0032060) |
| 1.6 | 9.7 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.4 | 9.1 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 18.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 15.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 15.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.7 | 13.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 11.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 10.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.8 | 9.7 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.2 | 9.7 | GO:0008305 | integrin complex(GO:0008305) |
| 0.5 | 8.9 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 12.8 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.3 | 12.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.9 | 12.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.4 | 11.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 10.3 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 2.0 | 10.2 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.1 | 10.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.4 | 9.7 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 2.3 | 9.0 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 14.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 14.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 11.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 11.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 10.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 10.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 9.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 7.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 7.0 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.5 | 13.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.4 | 12.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 11.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 11.0 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 10.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 9.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 9.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 8.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 7.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |