ISMARA results: TLX2

Project

Illumina Body Map 2: averaged replicates

Navigation

Downloads

Results for TLX2

Z-value: 2.21

Motif logo

Transcription factors associated with TLX2

Gene Symbol	Gene ID	Gene Info
TLX2 Ensembl NCBI GeneCards UniProt	ENSG00000115297.9	T cell leukemia homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TLX2	hg19_v2_chr2_+_74741569_74741620	-0.55	1.2e-03	Click!

Activity profile of TLX2 motif

Sorted Z-values of TLX2 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_117085336 Show fit	4.48	ENST00000259396.8 ENST00000538816.1	ORM1 Ensembl NCBI GeneCards UniProt Show fit	orosomucoid 1
chr7_-_99573677 Show fit	3.50	ENST00000292401.4	AZGP1 Ensembl NCBI GeneCards UniProt Show fit	alpha-2-glycoprotein 1, zinc-binding
chr7_-_99573640 Show fit	3.31	ENST00000411734.1	AZGP1 Ensembl NCBI GeneCards UniProt Show fit	alpha-2-glycoprotein 1, zinc-binding
chr19_+_52264104 Show fit	3.22	ENST00000340023.6	FPR2 Ensembl NCBI GeneCards UniProt Show fit	formyl peptide receptor 2
chr19_+_7733929 Show fit	3.17	ENST00000221515.2	RETN Ensembl NCBI GeneCards UniProt Show fit	resistin
chr9_+_117092149 Show fit	3.02	ENST00000431067.2 ENST00000412657.1	ORM2 Ensembl NCBI GeneCards UniProt Show fit	orosomucoid 2
chr1_+_57320437 Show fit	2.51	ENST00000361249.3	C8A Ensembl NCBI GeneCards UniProt Show fit	complement component 8, alpha polypeptide
chr6_-_49712147 Show fit	2.50	ENST00000433368.2 ENST00000354620.4	CRISP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine-rich secretory protein 3
chr6_-_49712123 Show fit	2.46	ENST00000263045.4	CRISP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine-rich secretory protein 3
chr1_-_36947120 Show fit	2.44	ENST00000361632.4	CSF3R Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 3 receptor (granulocyte)
chr20_-_7238861 Show fit	2.44	ENST00000428954.1	RP11-19D2.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-19D2.1
chr19_+_15752088 Show fit	2.40	ENST00000585846.1	CYP4F3 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450, family 4, subfamily F, polypeptide 3
chr2_+_102927962 Show fit	2.40	ENST00000233954.1 ENST00000393393.3 ENST00000410040.1	IL1RL1 Ensembl NCBI GeneCards UniProt Show fit IL18R1 Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor-like 1 interleukin 18 receptor 1
chr2_+_102928009 Show fit	2.32	ENST00000404917.2 ENST00000447231.1	IL1RL1 Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor-like 1
chr2_+_17721920 Show fit	2.26	ENST00000295156.4	VSNL1 Ensembl NCBI GeneCards UniProt Show fit	visinin-like 1
chr1_-_153363452 Show fit	2.17	ENST00000368732.1 ENST00000368733.3	S100A8 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A8
chr12_-_96389702 Show fit	2.16	ENST00000552509.1	HAL Ensembl NCBI GeneCards UniProt Show fit	histidine ammonia-lyase
chr1_+_153330322 Show fit	2.12	ENST00000368738.3	S100A9 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A9
chrX_+_153627231 Show fit	1.94	ENST00000406022.2	RPL10 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L10
chr16_+_82068830 Show fit	1.93	ENST00000199936.4	HSD17B2 Ensembl NCBI GeneCards UniProt Show fit	hydroxysteroid (17-beta) dehydrogenase 2
chr5_+_36606700 Show fit	1.91	ENST00000416645.2	SLC1A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_11002063 Show fit	1.79	ENST00000544994.1 ENST00000228811.4 ENST00000540107.1	PRR4 Ensembl NCBI GeneCards UniProt Show fit	proline rich 4 (lacrimal)
chr5_+_147258266 Show fit	1.78	ENST00000296694.4	SCGB3A2 Ensembl NCBI GeneCards UniProt Show fit	secretoglobin, family 3A, member 2
chr19_-_52150053 Show fit	1.78	ENST00000599649.1 ENST00000429354.3 ENST00000360844.6 ENST00000222107.4	SIGLEC5 Ensembl NCBI GeneCards UniProt Show fit SIGLEC14 Ensembl NCBI GeneCards UniProt Show fit SIGLEC5 Ensembl NCBI GeneCards UniProt Show fit	SIGLEC5 sialic acid binding Ig-like lectin 14 sialic acid binding Ig-like lectin 5
chr6_-_49712091 Show fit	1.76	ENST00000371159.4	CRISP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine-rich secretory protein 3
chr1_+_196946680 Show fit	1.76	ENST00000256785.4	CFHR5 Ensembl NCBI GeneCards UniProt Show fit	complement factor H-related 5
chr20_-_1472121 Show fit	1.72	ENST00000444444.2	SIRPB2 Ensembl NCBI GeneCards UniProt Show fit	signal-regulatory protein beta 2
chr8_-_134511587 Show fit	1.71	ENST00000523855.1 ENST00000523854.1	ST3GAL1 Ensembl NCBI GeneCards UniProt Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr12_+_109569155 Show fit	1.71	ENST00000539864.1	ACACB Ensembl NCBI GeneCards UniProt Show fit	acetyl-CoA carboxylase beta
chr3_+_121796697 Show fit	1.67	ENST00000482356.1 ENST00000393627.2	CD86 Ensembl NCBI GeneCards UniProt Show fit	CD86 molecule
chr5_-_41213123 Show fit	1.67	ENST00000417809.1	C6 Ensembl NCBI GeneCards UniProt Show fit	complement component 6
chr3_+_121774202 Show fit	1.65	ENST00000469710.1 ENST00000493101.1 ENST00000330540.2 ENST00000264468.5	CD86 Ensembl NCBI GeneCards UniProt Show fit	CD86 molecule
chr19_+_52264449 Show fit	1.65	ENST00000599326.1 ENST00000598953.1	FPR2 Ensembl NCBI GeneCards UniProt Show fit	formyl peptide receptor 2
chr6_-_49712072 Show fit	1.65	ENST00000423399.2	CRISP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine-rich secretory protein 3
chr6_-_32498046 Show fit	1.65	ENST00000374975.3	HLA-DRB5 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DR beta 5
chrX_+_153626708 Show fit	1.61	ENST00000436473.1 ENST00000344746.4 ENST00000458500.1	RPL10 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L10
chr2_+_128180842 Show fit	1.60	ENST00000402125.2	PROC Ensembl NCBI GeneCards UniProt Show fit	protein C (inactivator of coagulation factors Va and VIIIa)
chr16_+_82068873 Show fit	1.59	ENST00000566213.1	HSD17B2 Ensembl NCBI GeneCards UniProt Show fit	hydroxysteroid (17-beta) dehydrogenase 2
chr12_+_57522692 Show fit	1.58	ENST00000554174.1	LRP1 Ensembl NCBI GeneCards UniProt Show fit	low density lipoprotein receptor-related protein 1
chr12_-_33049690 Show fit	1.55	ENST00000070846.6 ENST00000340811.4	PKP2 Ensembl NCBI GeneCards UniProt Show fit	plakophilin 2
chr11_+_62186498 Show fit	1.54	ENST00000278282.2	SCGB1A1 Ensembl NCBI GeneCards UniProt Show fit	secretoglobin, family 1A, member 1 (uteroglobin)
chr3_+_52811596 Show fit	1.52	ENST00000542827.1 ENST00000273283.2	ITIH1 Ensembl NCBI GeneCards UniProt Show fit	inter-alpha-trypsin inhibitor heavy chain 1
chr20_-_1472053 Show fit	1.51	ENST00000537284.1	SIRPB2 Ensembl NCBI GeneCards UniProt Show fit	signal-regulatory protein beta 2
chr2_+_63816126 Show fit	1.51	ENST00000454035.1	MDH1 Ensembl NCBI GeneCards UniProt Show fit	malate dehydrogenase 1, NAD (soluble)
chr1_+_196946664 Show fit	1.49	ENST00000367414.5	CFHR5 Ensembl NCBI GeneCards UniProt Show fit	complement factor H-related 5
chr5_+_67576109 Show fit	1.45	ENST00000522084.1	PIK3R1 Ensembl NCBI GeneCards UniProt Show fit	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr8_-_82024290 Show fit	1.44	ENST00000220597.4	PAG1 Ensembl NCBI GeneCards UniProt Show fit	phosphoprotein associated with glycosphingolipid microdomains 1
chr7_-_120497178 Show fit	1.44	ENST00000441017.1 ENST00000424710.1 ENST00000433758.1	TSPAN12 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 12
chr3_+_148847371 Show fit	1.42	ENST00000296051.2 ENST00000460120.1	HPS3 Ensembl NCBI GeneCards UniProt Show fit	Hermansky-Pudlak syndrome 3
chr2_+_63816295 Show fit	1.40	ENST00000539945.1 ENST00000544381.1	MDH1 Ensembl NCBI GeneCards UniProt Show fit	malate dehydrogenase 1, NAD (soluble)
chr2_-_40739501 Show fit	1.39	ENST00000403092.1 ENST00000402441.1 ENST00000448531.1	SLC8A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_-_135433534 Show fit	1.36	ENST00000338588.3	FAM180A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 180, member A
chr19_-_52133588 Show fit	1.36	ENST00000570106.2	SIGLEC5 Ensembl NCBI GeneCards UniProt Show fit	sialic acid binding Ig-like lectin 5
chr1_-_183538319 Show fit	1.35	ENST00000420553.1 ENST00000419402.1	NCF2 Ensembl NCBI GeneCards UniProt Show fit	neutrophil cytosolic factor 2
chr20_-_1472029 Show fit	1.34	ENST00000359801.3	SIRPB2 Ensembl NCBI GeneCards UniProt Show fit	signal-regulatory protein beta 2
chr20_-_1373682 Show fit	1.33	ENST00000381724.3	FKBP1A Ensembl NCBI GeneCards UniProt Show fit	FK506 binding protein 1A, 12kDa
chrX_+_153626571 Show fit	1.32	ENST00000424325.2	RPL10 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L10
chr5_+_96077888 Show fit	1.31	ENST00000509259.1 ENST00000503828.1	CAST Ensembl NCBI GeneCards UniProt Show fit	calpastatin
chr7_-_135433460 Show fit	1.31	ENST00000415751.1	FAM180A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 180, member A
chr7_+_155090271 Show fit	1.31	ENST00000476756.1	INSIG1 Ensembl NCBI GeneCards UniProt Show fit	insulin induced gene 1
chr1_+_186265399 Show fit	1.31	ENST00000367486.3 ENST00000367484.3 ENST00000533951.1 ENST00000367482.4 ENST00000367483.4 ENST00000367485.4 ENST00000445192.2	PRG4 Ensembl NCBI GeneCards UniProt Show fit	proteoglycan 4
chr15_+_89631381 Show fit	1.30	ENST00000352732.5	ABHD2 Ensembl NCBI GeneCards UniProt Show fit	abhydrolase domain containing 2
chr3_-_150966902 Show fit	1.30	ENST00000424796.2	P2RY14 Ensembl NCBI GeneCards UniProt Show fit	purinergic receptor P2Y, G-protein coupled, 14
chr7_-_38398721 Show fit	1.29	ENST00000390346.2	TRGV3 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor gamma variable 3
chr2_+_63816269 Show fit	1.29	ENST00000432309.1	MDH1 Ensembl NCBI GeneCards UniProt Show fit	malate dehydrogenase 1, NAD (soluble)
chr2_+_63816087 Show fit	1.29	ENST00000409908.1 ENST00000442225.1 ENST00000409476.1 ENST00000436321.1	MDH1 Ensembl NCBI GeneCards UniProt Show fit	malate dehydrogenase 1, NAD (soluble)
chr17_+_7211280 Show fit	1.29	ENST00000419711.2 ENST00000571955.1 ENST00000573714.1	EIF5A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 5A
chr19_-_51920873 Show fit	1.26	ENST00000441969.3 ENST00000525998.1 ENST00000436984.2	SIGLEC10 Ensembl NCBI GeneCards UniProt Show fit	sialic acid binding Ig-like lectin 10
chr10_+_124768482 Show fit	1.24	ENST00000368869.4 ENST00000358776.4	ACADSB Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA dehydrogenase, short/branched chain
chr2_+_44066101 Show fit	1.24	ENST00000272286.2	ABCG8 Ensembl NCBI GeneCards UniProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 8
chr10_-_60027642 Show fit	1.23	ENST00000373935.3	IPMK Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate multikinase
chr3_+_186435137 Show fit	1.23	ENST00000447445.1	KNG1 Ensembl NCBI GeneCards UniProt Show fit	kininogen 1
chr1_+_214161272 Show fit	1.23	ENST00000498508.2 ENST00000366958.4	PROX1 Ensembl NCBI GeneCards UniProt Show fit	prospero homeobox 1
chrX_+_46940254 Show fit	1.23	ENST00000336169.3	RGN Ensembl NCBI GeneCards UniProt Show fit	regucalcin
chr14_+_104552016 Show fit	1.21	ENST00000551177.1 ENST00000546892.2 ENST00000455920.2	ASPG Ensembl NCBI GeneCards UniProt Show fit	asparaginase homolog (S. cerevisiae)
chr16_+_29674540 Show fit	1.21	ENST00000436527.1 ENST00000360121.3 ENST00000449759.1	SPN Ensembl NCBI GeneCards UniProt Show fit QPRT Ensembl NCBI GeneCards UniProt Show fit	sialophorin quinolinate phosphoribosyltransferase
chr16_-_11681023 Show fit	1.21	ENST00000570904.1 ENST00000574701.1	LITAF Ensembl NCBI GeneCards UniProt Show fit	lipopolysaccharide-induced TNF factor
chr8_-_16035454 Show fit	1.21	ENST00000355282.2	MSR1 Ensembl NCBI GeneCards UniProt Show fit	macrophage scavenger receptor 1
chr4_-_165305086 Show fit	1.20	ENST00000507270.1 ENST00000514618.1 ENST00000503008.1	MARCH1 Ensembl NCBI GeneCards UniProt Show fit	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr3_+_186435065 Show fit	1.20	ENST00000287611.2 ENST00000265023.4	KNG1 Ensembl NCBI GeneCards UniProt Show fit	kininogen 1
chr14_+_88471468 Show fit	1.19	ENST00000267549.3	GPR65 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 65
chr19_-_11688447 Show fit	1.18	ENST00000590420.1	ACP5 Ensembl NCBI GeneCards UniProt Show fit	acid phosphatase 5, tartrate resistant
chr5_+_36606992 Show fit	1.18	ENST00000505202.1	SLC1A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_102323740 Show fit	1.16	ENST00000398136.2	TMEM123 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 123
chr1_+_159772121 Show fit	1.14	ENST00000339348.5 ENST00000392235.3 ENST00000368106.3	FCRL6 Ensembl NCBI GeneCards UniProt Show fit	Fc receptor-like 6
chr12_+_57522439 Show fit	1.14	ENST00000338962.4	LRP1 Ensembl NCBI GeneCards UniProt Show fit	low density lipoprotein receptor-related protein 1
chr8_+_86376081 Show fit	1.13	ENST00000285379.5	CA2 Ensembl NCBI GeneCards UniProt Show fit	carbonic anhydrase II
chr6_-_138428613 Show fit	1.13	ENST00000421351.3	PERP Ensembl NCBI GeneCards UniProt Show fit	PERP, TP53 apoptosis effector
chr19_-_51920952 Show fit	1.12	ENST00000356298.5 ENST00000339313.5 ENST00000529627.1 ENST00000439889.2 ENST00000353836.5 ENST00000432469.2	SIGLEC10 Ensembl NCBI GeneCards UniProt Show fit	sialic acid binding Ig-like lectin 10
chr2_+_17721937 Show fit	1.12	ENST00000451533.1	VSNL1 Ensembl NCBI GeneCards UniProt Show fit	visinin-like 1
chr1_+_74663896 Show fit	1.10	ENST00000370898.3 ENST00000467578.2 ENST00000370894.5 ENST00000482102.2 ENST00000609362.1 ENST00000534056.1 ENST00000557284.2 ENST00000370899.3 ENST00000370895.1 ENST00000534632.1 ENST00000370893.1 ENST00000370891.2	FPGT Ensembl NCBI GeneCards UniProt Show fit FPGT-TNNI3K Ensembl NCBI GeneCards UniProt Show fit TNNI3K Ensembl NCBI GeneCards UniProt Show fit	fucose-1-phosphate guanylyltransferase FPGT-TNNI3K readthrough TNNI3 interacting kinase
chr6_+_131148538 Show fit	1.10	ENST00000541421.2	SMLR1 Ensembl NCBI GeneCards UniProt Show fit	small leucine-rich protein 1
chr16_-_11680759 Show fit	1.09	ENST00000571459.1 ENST00000570798.1 ENST00000572255.1 ENST00000574763.1 ENST00000574703.1 ENST00000571277.1 ENST00000381810.3	LITAF Ensembl NCBI GeneCards UniProt Show fit	lipopolysaccharide-induced TNF factor
chr19_+_39421556 Show fit	1.08	ENST00000407800.2 ENST00000402029.3	MRPS12 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein S12
chr7_+_139528952 Show fit	1.08	ENST00000416849.2 ENST00000436047.2 ENST00000414508.2 ENST00000448866.1	TBXAS1 Ensembl NCBI GeneCards UniProt Show fit	thromboxane A synthase 1 (platelet)
chr12_-_123565834 Show fit	1.08	ENST00000546049.1	PITPNM2 Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol transfer protein, membrane-associated 2
chr3_+_30647994 Show fit	1.07	ENST00000295754.5	TGFBR2 Ensembl NCBI GeneCards UniProt Show fit	transforming growth factor, beta receptor II (70/80kDa)
chr7_+_139529040 Show fit	1.05	ENST00000455353.1 ENST00000458722.1 ENST00000411653.1	TBXAS1 Ensembl NCBI GeneCards UniProt Show fit	thromboxane A synthase 1 (platelet)
chr3_+_124355944 Show fit	1.05	ENST00000459915.1	KALRN Ensembl NCBI GeneCards UniProt Show fit	kalirin, RhoGEF kinase
chr9_-_117692697 Show fit	1.04	ENST00000223795.2	TNFSF8 Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 8
chr5_+_95998673 Show fit	1.03	ENST00000514845.1	CAST Ensembl NCBI GeneCards UniProt Show fit	calpastatin
chr19_+_840963 Show fit	1.03	ENST00000234347.5	PRTN3 Ensembl NCBI GeneCards UniProt Show fit	proteinase 3
chr11_-_64510409 Show fit	1.03	ENST00000394429.1 ENST00000394428.1	RASGRP2 Ensembl NCBI GeneCards UniProt Show fit	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr1_+_74663994 Show fit	1.03	ENST00000472069.1	FPGT Ensembl NCBI GeneCards UniProt Show fit	fucose-1-phosphate guanylyltransferase
chr15_+_89631647 Show fit	1.03	ENST00000569550.1 ENST00000565066.1 ENST00000565973.1	ABHD2 Ensembl NCBI GeneCards UniProt Show fit	abhydrolase domain containing 2
chr12_+_12938541 Show fit	1.02	ENST00000356591.4	APOLD1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L domain containing 1
chr1_-_68698197 Show fit	1.02	ENST00000370973.2 ENST00000370971.1	WLS Ensembl NCBI GeneCards UniProt Show fit	wntless Wnt ligand secretion mediator
chr1_-_31230650 Show fit	1.02	ENST00000294507.3	LAPTM5 Ensembl NCBI GeneCards UniProt Show fit	lysosomal protein transmembrane 5
chr2_-_44065946 Show fit	0.99	ENST00000260645.1	ABCG5 Ensembl NCBI GeneCards UniProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 5
chr5_-_151138200 Show fit	0.96	ENST00000313115.6 ENST00000522710.1	ATOX1 Ensembl NCBI GeneCards UniProt Show fit	antioxidant 1 copper chaperone
chr1_+_205473784 Show fit	0.95	ENST00000478560.1 ENST00000443813.2	CDK18 Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase 18
chr3_+_46412345 Show fit	0.95	ENST00000292303.4	CCR5 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr18_-_61034416 Show fit	0.95	ENST00000326575.5 ENST00000592327.1	KDSR Ensembl NCBI GeneCards UniProt Show fit	3-ketodihydrosphingosine reductase
chr7_-_32111009 Show fit	0.95	ENST00000396184.3 ENST00000396189.2 ENST00000321453.7	PDE1C Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 1C, calmodulin-dependent 70kDa
chr16_+_31119615 Show fit	0.94	ENST00000394950.3 ENST00000287507.3 ENST00000219794.6 ENST00000561755.1	BCKDK Ensembl NCBI GeneCards UniProt Show fit	branched chain ketoacid dehydrogenase kinase
chr8_-_134584092 Show fit	0.94	ENST00000522652.1	ST3GAL1 Ensembl NCBI GeneCards UniProt Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr9_+_116267536 Show fit	0.94	ENST00000374136.1	RGS3 Ensembl NCBI GeneCards UniProt Show fit	regulator of G-protein signaling 3
chr1_-_68698222 Show fit	0.94	ENST00000370976.3 ENST00000354777.2 ENST00000262348.4 ENST00000540432.1	WLS Ensembl NCBI GeneCards UniProt Show fit	wntless Wnt ligand secretion mediator
chr20_-_33732952 Show fit	0.93	ENST00000541621.1	EDEM2 Ensembl NCBI GeneCards UniProt Show fit	ER degradation enhancer, mannosidase alpha-like 2
chr14_-_92588013 Show fit	0.93	ENST00000553514.1 ENST00000605997.1	NDUFB1 Ensembl NCBI GeneCards UniProt Show fit	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr14_-_92588246 Show fit	0.93	ENST00000329559.3	NDUFB1 Ensembl NCBI GeneCards UniProt Show fit	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr22_+_19706958 Show fit	0.92	ENST00000395109.2	SEPT5 Ensembl NCBI GeneCards UniProt Show fit	septin 5
chr6_-_25930819 Show fit	0.92	ENST00000360488.3	SLC17A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 17, member 2
chr12_-_57522813 Show fit	0.91	ENST00000556155.1	STAT6 Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 6, interleukin-4 induced
chr6_-_32977345 Show fit	0.91	ENST00000450833.2 ENST00000374813.1 ENST00000229829.5	HLA-DOA Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DO alpha
chr18_+_29078131 Show fit	0.91	ENST00000585206.1	DSG2 Ensembl NCBI GeneCards UniProt Show fit	desmoglein 2
chr10_+_115312766 Show fit	0.91	ENST00000351270.3	HABP2 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan binding protein 2
chr11_-_118083600 Show fit	0.90	ENST00000524477.1	AMICA1 Ensembl NCBI GeneCards UniProt Show fit	adhesion molecule, interacts with CXADR antigen 1
chr13_-_50265570 Show fit	0.90	ENST00000378270.5 ENST00000378284.2 ENST00000378272.5 ENST00000378268.1 ENST00000242827.6 ENST00000378282.5	EBPL Ensembl NCBI GeneCards UniProt Show fit	emopamil binding protein-like
chr2_-_44065889 Show fit	0.90	ENST00000543989.1 ENST00000405322.1	ABCG5 Ensembl NCBI GeneCards UniProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 5
chr12_+_64798826 Show fit	0.89	ENST00000540203.1	XPOT Ensembl NCBI GeneCards UniProt Show fit	exportin, tRNA
chr1_+_53480598 Show fit	0.89	ENST00000430330.2 ENST00000408941.3 ENST00000478274.2 ENST00000484100.1 ENST00000435345.2 ENST00000488965.1	SCP2 Ensembl NCBI GeneCards UniProt Show fit	sterol carrier protein 2
chr19_-_51920835 Show fit	0.89	ENST00000442846.3 ENST00000530476.1	SIGLEC10 Ensembl NCBI GeneCards UniProt Show fit	sialic acid binding Ig-like lectin 10
chr6_-_25930904 Show fit	0.89	ENST00000377850.3	SLC17A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 17, member 2
chr6_-_41006928 Show fit	0.87	ENST00000244565.3	UNC5CL Ensembl NCBI GeneCards UniProt Show fit	unc-5 homolog C (C. elegans)-like
chr12_+_9144626 Show fit	0.86	ENST00000543895.1	KLRG1 Ensembl NCBI GeneCards UniProt Show fit	killer cell lectin-like receptor subfamily G, member 1
chr17_-_76128488 Show fit	0.86	ENST00000322914.3	TMC6 Ensembl NCBI GeneCards UniProt Show fit	transmembrane channel-like 6
chr3_+_132036207 Show fit	0.86	ENST00000336375.5 ENST00000495911.1	ACPP Ensembl NCBI GeneCards UniProt Show fit	acid phosphatase, prostate
chr20_+_62367989 Show fit	0.85	ENST00000309546.3	LIME1 Ensembl NCBI GeneCards UniProt Show fit	Lck interacting transmembrane adaptor 1
chr9_-_128003606 Show fit	0.85	ENST00000324460.6	HSPA5 Ensembl NCBI GeneCards UniProt Show fit	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr5_+_67576062 Show fit	0.85	ENST00000523807.1	PIK3R1 Ensembl NCBI GeneCards UniProt Show fit	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr3_-_178789220 Show fit	0.84	ENST00000414084.1	ZMAT3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger, matrin-type 3
chr6_-_66417107 Show fit	0.84	ENST00000370621.3 ENST00000370618.3 ENST00000503581.1 ENST00000393380.2	EYS Ensembl NCBI GeneCards UniProt Show fit	eyes shut homolog (Drosophila)
chr20_-_1373726 Show fit	0.84	ENST00000400137.4	FKBP1A Ensembl NCBI GeneCards UniProt Show fit	FK506 binding protein 1A, 12kDa
chr20_-_1373606 Show fit	0.83	ENST00000381715.1 ENST00000439640.2 ENST00000381719.3	FKBP1A Ensembl NCBI GeneCards UniProt Show fit	FK506 binding protein 1A, 12kDa
chr19_-_11688500 Show fit	0.83	ENST00000433365.2	ACP5 Ensembl NCBI GeneCards UniProt Show fit	acid phosphatase 5, tartrate resistant
chr7_+_139529085 Show fit	0.82	ENST00000539806.1	TBXAS1 Ensembl NCBI GeneCards UniProt Show fit	thromboxane A synthase 1 (platelet)
chr20_-_656437 Show fit	0.82	ENST00000488788.2	RP5-850E9.3 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr16_-_3306587 Show fit	0.82	ENST00000541159.1 ENST00000536379.1 ENST00000219596.1 ENST00000339854.4	MEFV Ensembl NCBI GeneCards UniProt Show fit	Mediterranean fever
chr8_-_134584152 Show fit	0.81	ENST00000521180.1 ENST00000517668.1 ENST00000319914.5	ST3GAL1 Ensembl NCBI GeneCards UniProt Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_+_62417957 Show fit	0.81	ENST00000307297.7 ENST00000543708.1	INADL Ensembl NCBI GeneCards UniProt Show fit	InaD-like (Drosophila)
chr11_+_65339820 Show fit	0.81	ENST00000316409.2 ENST00000449319.2 ENST00000530349.1	FAM89B Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 89, member B
chr10_+_115312825 Show fit	0.80	ENST00000537906.1 ENST00000541666.1	HABP2 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan binding protein 2
chr5_+_110407390 Show fit	0.80	ENST00000344895.3	TSLP Ensembl NCBI GeneCards UniProt Show fit	thymic stromal lymphopoietin
chr3_-_129279894 Show fit	0.80	ENST00000506979.1	PLXND1 Ensembl NCBI GeneCards UniProt Show fit	plexin D1
chr19_-_45953983 Show fit	0.78	ENST00000592083.1	ERCC1 Ensembl NCBI GeneCards UniProt Show fit	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr11_+_93474786 Show fit	0.78	ENST00000331239.4 ENST00000533585.1 ENST00000528099.1 ENST00000354421.3 ENST00000540113.1 ENST00000530620.1 ENST00000527003.1 ENST00000531650.1 ENST00000530279.1	C11orf54 Ensembl NCBI GeneCards UniProt Show fit	chromosome 11 open reading frame 54
chr11_+_93474757 Show fit	0.78	ENST00000528288.1	C11orf54 Ensembl NCBI GeneCards UniProt Show fit	chromosome 11 open reading frame 54
chr9_+_116225999 Show fit	0.78	ENST00000317613.6	RGS3 Ensembl NCBI GeneCards UniProt Show fit	regulator of G-protein signaling 3
chr8_+_38758737 Show fit	0.78	ENST00000521746.1 ENST00000420274.1	PLEKHA2 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr14_-_106622419 Show fit	0.78	ENST00000390604.2	IGHV3-16 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 3-16 (non-functional)
chr15_+_81475047 Show fit	0.77	ENST00000559388.1	IL16 Ensembl NCBI GeneCards UniProt Show fit	interleukin 16
chr2_+_10263298 Show fit	0.77	ENST00000474701.1	RRM2 Ensembl NCBI GeneCards UniProt Show fit	ribonucleotide reductase M2
chr1_-_25291475 Show fit	0.77	ENST00000338888.3 ENST00000399916.1	RUNX3 Ensembl NCBI GeneCards UniProt Show fit	runt-related transcription factor 3
chr12_-_51740463 Show fit	0.77	ENST00000293636.1	CELA1 Ensembl NCBI GeneCards UniProt Show fit	chymotrypsin-like elastase family, member 1
chr16_+_19183671 Show fit	0.77	ENST00000562711.2	SYT17 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin XVII
chr16_+_30075463 Show fit	0.77	ENST00000562168.1 ENST00000569545.1	ALDOA Ensembl NCBI GeneCards UniProt Show fit	aldolase A, fructose-bisphosphate
chr18_-_2982869 Show fit	0.76	ENST00000584915.1	LPIN2 Ensembl NCBI GeneCards UniProt Show fit	lipin 2
chr2_-_190445499 Show fit	0.75	ENST00000261024.2	SLC40A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 40 (iron-regulated transporter), member 1
chr4_+_156680518 Show fit	0.75	ENST00000513437.1	GUCY1B3 Ensembl NCBI GeneCards UniProt Show fit	guanylate cyclase 1, soluble, beta 3
chr11_-_64889252 Show fit	0.75	ENST00000525297.1 ENST00000529259.1	FAU Ensembl NCBI GeneCards UniProt Show fit	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr1_+_151030234 Show fit	0.75	ENST00000368921.3	MLLT11 Ensembl NCBI GeneCards UniProt Show fit	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_-_120938303 Show fit	0.75	ENST00000356951.3 ENST00000298510.2	PRDX3 Ensembl NCBI GeneCards UniProt Show fit	peroxiredoxin 3
chr20_+_43835638 Show fit	0.75	ENST00000372781.3 ENST00000244069.6	SEMG1 Ensembl NCBI GeneCards UniProt Show fit	semenogelin I
chr8_+_18067602 Show fit	0.74	ENST00000307719.4 ENST00000545197.1 ENST00000539092.1 ENST00000541942.1 ENST00000518029.1	NAT1 Ensembl NCBI GeneCards UniProt Show fit	N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr16_-_11680791 Show fit	0.74	ENST00000571976.1 ENST00000413364.2	LITAF Ensembl NCBI GeneCards UniProt Show fit	lipopolysaccharide-induced TNF factor
chr12_+_6494285 Show fit	0.74	ENST00000541102.1	LTBR Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin beta receptor (TNFR superfamily, member 3)
chr1_+_205473720 Show fit	0.74	ENST00000429964.2 ENST00000506784.1 ENST00000360066.2	CDK18 Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase 18
chr1_-_153949751 Show fit	0.73	ENST00000428469.1	JTB Ensembl NCBI GeneCards UniProt Show fit	jumping translocation breakpoint
chr11_+_128563652 Show fit	0.72	ENST00000527786.2	FLI1 Ensembl NCBI GeneCards UniProt Show fit	Fli-1 proto-oncogene, ETS transcription factor
chr19_+_16999966 Show fit	0.72	ENST00000599210.1	F2RL3 Ensembl NCBI GeneCards UniProt Show fit	coagulation factor II (thrombin) receptor-like 3
chr19_-_6670128 Show fit	0.72	ENST00000245912.3	TNFSF14 Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 14
chr12_-_71031185 Show fit	0.71	ENST00000548122.1 ENST00000551525.1 ENST00000550358.1	PTPRB Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase, receptor type, B
chr15_+_69745123 Show fit	0.71	ENST00000260379.6 ENST00000357790.5 ENST00000560274.1	RPLP1 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein, large, P1
chr7_-_120498357 Show fit	0.71	ENST00000415871.1 ENST00000222747.3 ENST00000430985.1	TSPAN12 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 12
chr4_+_156680143 Show fit	0.70	ENST00000505154.1	GUCY1B3 Ensembl NCBI GeneCards UniProt Show fit	guanylate cyclase 1, soluble, beta 3
chr14_+_23341513 Show fit	0.69	ENST00000546834.1	LRP10 Ensembl NCBI GeneCards UniProt Show fit	low density lipoprotein receptor-related protein 10
chr2_+_169923504 Show fit	0.69	ENST00000357546.2	DHRS9 Ensembl NCBI GeneCards UniProt Show fit	dehydrogenase/reductase (SDR family) member 9
chr14_+_23299088 Show fit	0.69	ENST00000355151.5 ENST00000397496.3 ENST00000555345.1 ENST00000432849.3 ENST00000553711.1 ENST00000556465.1 ENST00000397505.2 ENST00000557221.1 ENST00000311892.6 ENST00000556840.1 ENST00000555536.1	MRPL52 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L52
chr19_+_1067271 Show fit	0.69	ENST00000536472.1 ENST00000590214.1	HMHA1 Ensembl NCBI GeneCards UniProt Show fit	histocompatibility (minor) HA-1
chr12_-_71031220 Show fit	0.69	ENST00000334414.6	PTPRB Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase, receptor type, B
chr16_+_29150963 Show fit	0.69	ENST00000563477.1	RP11-426C22.5 Ensembl NCBI GeneCards UniProt Show fit	RP11-426C22.5
chr3_+_50192457 Show fit	0.69	ENST00000414301.1 ENST00000450338.1	SEMA3F Ensembl NCBI GeneCards UniProt Show fit	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_1026566 Show fit	0.68	ENST00000348419.3 ENST00000565096.2 ENST00000562958.2 ENST00000562075.2 ENST00000607102.1	CNN2 Ensembl NCBI GeneCards UniProt Show fit	calponin 2
chr19_-_52035044 Show fit	0.68	ENST00000359982.4 ENST00000436458.1 ENST00000425629.3 ENST00000391797.3 ENST00000343300.4	SIGLEC6 Ensembl NCBI GeneCards UniProt Show fit	sialic acid binding Ig-like lectin 6
chr22_+_43547520 Show fit	0.68	ENST00000337554.3 ENST00000396265.3 ENST00000583777.1	TSPO Ensembl NCBI GeneCards UniProt Show fit	translocator protein (18kDa)
chr7_+_99971129 Show fit	0.68	ENST00000394000.2 ENST00000350573.2	PILRA Ensembl NCBI GeneCards UniProt Show fit	paired immunoglobin-like type 2 receptor alpha
chr17_-_9862772 Show fit	0.68	ENST00000580865.1 ENST00000583882.1	GAS7 Ensembl NCBI GeneCards UniProt Show fit	growth arrest-specific 7
chr14_-_54955376 Show fit	0.68	ENST00000553333.1	GMFB Ensembl NCBI GeneCards UniProt Show fit	glia maturation factor, beta
chr18_+_29077990 Show fit	0.68	ENST00000261590.8	DSG2 Ensembl NCBI GeneCards UniProt Show fit	desmoglein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.3	GO:0002644	negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
1.1	3.2	GO:2000196	positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
1.0	3.1	GO:0045796	negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.7	2.1	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.7	4.7	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.6	1.9	GO:2000979	hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.6	7.5	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.5	2.7	GO:1905167	positive regulation of lysosomal protein catabolic process(GO:1905167)
0.5	2.0	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
0.4	1.3	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.4	1.2	GO:1903625	negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.4	1.6	GO:0044537	regulation of circulating fibrinogen levels(GO:0044537)
0.4	1.5	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.4	1.1	GO:0042938	dipeptide transport(GO:0042938)
0.4	2.2	GO:2001295	malonyl-CoA biosynthetic process(GO:2001295)
0.4	1.5	GO:0060168	positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.3	2.4	GO:0036101	leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.3	1.7	GO:0001970	positive regulation of activation of membrane attack complex(GO:0001970)
0.3	1.0	GO:2000409	astrocyte chemotaxis(GO:0035700) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) positive regulation of T cell extravasation(GO:2000409) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
0.3	5.5	GO:0006108	malate metabolic process(GO:0006108)
0.3	1.3	GO:2000434	regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.3	1.0	GO:0015680	intracellular copper ion transport(GO:0015680)
0.3	1.6	GO:0003165	Purkinje myocyte development(GO:0003165)
0.3	1.5	GO:0048496	adherens junction maintenance(GO:0034334) maintenance of organ identity(GO:0048496)
0.3	2.2	GO:0043606	histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.3	1.2	GO:0016598	protein arginylation(GO:0016598)
0.3	0.9	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.3	1.2	GO:0001808	regulation of type IV hypersensitivity(GO:0001807) negative regulation of type IV hypersensitivity(GO:0001808)
0.3	5.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.3	0.8	GO:0021589	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3	1.4	GO:1900005	positive regulation of serine-type endopeptidase activity(GO:1900005) negative regulation of sperm motility(GO:1901318) positive regulation of serine-type peptidase activity(GO:1902573)
0.3	3.1	GO:0070777	gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3	4.5	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.3	0.8	GO:0060392	negative regulation of SMAD protein import into nucleus(GO:0060392)
0.3	1.5	GO:0010193	response to ozone(GO:0010193)
0.3	2.0	GO:0038060	nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.3	2.0	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.3	0.8	GO:1903988	spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.2	1.2	GO:0051138	positive regulation of NK T cell differentiation(GO:0051138)
0.2	0.7	GO:0031247	actin rod assembly(GO:0031247)
0.2	1.1	GO:0000117	regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.2	2.9	GO:0022417	protein maturation by protein folding(GO:0022417)
0.2	0.6	GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.2	0.9	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2	0.6	GO:0001694	histamine biosynthetic process(GO:0001694)
0.2	1.0	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.2	0.8	GO:0001971	negative regulation of activation of membrane attack complex(GO:0001971)
0.2	0.8	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.2	0.7	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.2	0.9	GO:0036512	trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2	0.6	GO:0051040	regulation of calcium-independent cell-cell adhesion(GO:0051040)
0.2	1.1	GO:0061113	pancreas morphogenesis(GO:0061113)
0.2	0.6	GO:0006117	acetaldehyde metabolic process(GO:0006117)
0.2	0.9	GO:0002296	T-helper 1 cell lineage commitment(GO:0002296)
0.2	1.8	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.2	0.9	GO:1905040	vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.2	0.5	GO:0080121	coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.2	0.5	GO:0070781	arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.2	1.3	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.2	0.7	GO:2001160	regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.2	0.5	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.2	6.8	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2	0.6	GO:1903722	regulation of centriole elongation(GO:1903722)
0.2	0.2	GO:0032707	negative regulation of interleukin-23 production(GO:0032707)
0.2	2.2	GO:0032119	sequestering of zinc ion(GO:0032119)
0.2	0.6	GO:1990927	negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.2	0.9	GO:2000538	regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.2	1.4	GO:0030242	pexophagy(GO:0030242)
0.1	1.6	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.1	0.7	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1	2.7	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1	0.5	GO:0002501	peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1	0.8	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1	3.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.1	0.7	GO:0030573	bile acid catabolic process(GO:0030573)
0.1	1.1	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.1	0.8	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1	0.7	GO:0090370	negative regulation of cholesterol efflux(GO:0090370)
0.1	2.3	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1	3.5	GO:0006054	N-acetylneuraminate metabolic process(GO:0006054)
0.1	4.9	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.1	1.4	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.1	3.0	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.1	0.5	GO:1900138	negative regulation of phospholipase A2 activity(GO:1900138)
0.1	0.6	GO:0071409	cellular response to cycloheximide(GO:0071409)
0.1	0.6	GO:2000977	regulation of forebrain neuron differentiation(GO:2000977)
0.1	1.3	GO:0042905	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1	1.0	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.1	0.6	GO:1901979	regulation of inward rectifier potassium channel activity(GO:1901979)
0.1	0.8	GO:0032383	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1	1.2	GO:0006528	asparagine metabolic process(GO:0006528)
0.1	0.8	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1	2.7	GO:0006004	fucose metabolic process(GO:0006004)
0.1	1.8	GO:0045793	positive regulation of cell size(GO:0045793)
0.1	1.0	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1	0.9	GO:0036484	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1	0.4	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.1	0.4	GO:0035752	lysosomal lumen pH elevation(GO:0035752)
0.1	1.0	GO:0051956	negative regulation of amino acid transport(GO:0051956)
0.1	0.7	GO:0032252	secretory granule localization(GO:0032252)
0.1	0.4	GO:0035754	B cell chemotaxis(GO:0035754)
0.1	0.5	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1	3.8	GO:0097186	amelogenesis(GO:0097186)
0.1	0.3	GO:0032765	positive regulation of mast cell cytokine production(GO:0032765)
0.1	0.3	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.1	0.6	GO:1902045	negative regulation of Fas signaling pathway(GO:1902045)
0.1	2.9	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.1	0.3	GO:1990654	sebum secreting cell proliferation(GO:1990654)
0.1	0.5	GO:0001757	somite specification(GO:0001757)
0.1	0.7	GO:0010266	response to vitamin B1(GO:0010266)
0.1	0.4	GO:0035720	intraciliary anterograde transport(GO:0035720)
0.1	0.4	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.1	0.2	GO:1904875	regulation of DNA ligase activity(GO:1904875)
0.1	2.3	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.1	1.6	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.1	0.6	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1	1.0	GO:0010968	regulation of microtubule nucleation(GO:0010968)
0.1	0.9	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.1	0.8	GO:0090204	protein localization to nuclear pore(GO:0090204)
0.1	0.6	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1	0.3	GO:0042060	wound healing(GO:0042060)
0.1	3.6	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.1	0.9	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.1	0.4	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.1	2.2	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.1	0.1	GO:0033590	response to cobalamin(GO:0033590)
0.1	0.5	GO:0034350	regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1	0.5	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.1	0.6	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.1	2.3	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1	1.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	2.2	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.1	0.4	GO:0016476	regulation of embryonic cell shape(GO:0016476)
0.1	0.2	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1	0.5	GO:0006049	UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1	0.2	GO:0007231	osmosensory signaling pathway(GO:0007231)
0.1	0.1	GO:1990051	activation of protein kinase C activity(GO:1990051)
0.1	0.3	GO:0052551	response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.4	GO:0097461	copper ion import(GO:0015677) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1	1.7	GO:0048240	sperm capacitation(GO:0048240)
0.1	1.2	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	2.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.5	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.0	0.9	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	1.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	1.3	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.5	GO:0032482	Rab protein signal transduction(GO:0032482)
0.0	0.3	GO:0097498	endothelial tube lumen extension(GO:0097498)
0.0	1.9	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	2.1	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.6	GO:0060056	mammary gland involution(GO:0060056)
0.0	0.6	GO:0015824	proline transport(GO:0015824)
0.0	0.2	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.0	0.1	GO:0019858	cytosine metabolic process(GO:0019858)
0.0	1.7	GO:0042554	superoxide anion generation(GO:0042554)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.5	GO:0006477	protein sulfation(GO:0006477)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.3	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.2	GO:0010836	negative regulation of protein ADP-ribosylation(GO:0010836)
0.0	0.8	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.6	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.0	0.8	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.9	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.4	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.5	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0	0.6	GO:0010663	positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0	0.2	GO:0044240	activation of phospholipase A2 activity(GO:0032431) multicellular organism lipid catabolic process(GO:0044240)
0.0	1.5	GO:0032958	inositol phosphate biosynthetic process(GO:0032958)
0.0	0.5	GO:0006228	UTP biosynthetic process(GO:0006228)
0.0	0.5	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.4	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	2.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.3	GO:0097646	calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0	0.6	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.8	GO:0050962	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0	0.5	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.9	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.6	GO:0002643	regulation of tolerance induction(GO:0002643)
0.0	0.1	GO:0002517	T cell tolerance induction(GO:0002517)
0.0	0.5	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	0.6	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.3	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.7	GO:0006488	dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0	4.4	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.4	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.3	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.0	0.8	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.7	GO:0008228	opsonization(GO:0008228)
0.0	0.6	GO:0006071	glycerol metabolic process(GO:0006071)
0.0	0.4	GO:0002860	positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.2	GO:0097459	iron ion import into cell(GO:0097459) iron ion import across plasma membrane(GO:0098711)
0.0	0.3	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.7	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.2	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0	0.9	GO:0097421	liver regeneration(GO:0097421)
0.0	0.4	GO:0048675	axon extension(GO:0048675)
0.0	0.8	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.7	GO:0071466	xenobiotic metabolic process(GO:0006805) cellular response to xenobiotic stimulus(GO:0071466)
0.0	0.5	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	2.0	GO:0001895	retina homeostasis(GO:0001895)
0.0	0.8	GO:0032011	ARF protein signal transduction(GO:0032011)
0.0	2.3	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.8	GO:0035855	megakaryocyte development(GO:0035855)
0.0	0.1	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0	0.4	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	0.1	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.2	GO:0003344	pericardium morphogenesis(GO:0003344)
0.0	0.5	GO:0051601	exocyst localization(GO:0051601)
0.0	0.3	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.3	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0051664	nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0	0.7	GO:0045332	phospholipid translocation(GO:0045332)
0.0	3.1	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.0	0.1	GO:1903527	positive regulation of membrane tubulation(GO:1903527)
0.0	1.1	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.4	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:0019427	acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0	0.6	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
0.0	0.3	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.9	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	1.3	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0	0.3	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.6	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	15.1	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.3	GO:0038007	netrin-activated signaling pathway(GO:0038007)
0.0	0.3	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0032264	purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.0	0.2	GO:0009086	methionine biosynthetic process(GO:0009086)
0.0	0.1	GO:0034184	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.9	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	1.1	GO:0006826	iron ion transport(GO:0006826)
0.0	0.2	GO:0042330	chemotaxis(GO:0006935) taxis(GO:0042330)
0.0	0.1	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.2	GO:0034398	telomere tethering at nuclear periphery(GO:0034398)
0.0	0.6	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0042144	vacuole fusion, non-autophagic(GO:0042144)
0.0	0.3	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.1	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0	0.7	GO:0006298	mismatch repair(GO:0006298)
0.0	0.5	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.0	0.4	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.9	GO:0006968	cellular defense response(GO:0006968)
0.0	0.3	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.0	1.4	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.4	GO:0070828	heterochromatin organization(GO:0070828)
0.0	0.3	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.3	GO:0006895	Golgi to endosome transport(GO:0006895)
0.0	0.7	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	1.8	GO:0043473	pigmentation(GO:0043473)
0.0	0.1	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.4	GO:0010165	response to X-ray(GO:0010165)
0.0	0.3	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.2	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.0	GO:1990425	ryanodine receptor complex(GO:1990425)
0.5	2.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.4	4.2	GO:0005579	membrane attack complex(GO:0005579)
0.4	1.4	GO:0031084	BLOC-2 complex(GO:0031084)
0.3	3.0	GO:0098559	cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.3	2.3	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.2	0.6	GO:0036194	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2	20.9	GO:0035580	specific granule lumen(GO:0035580)
0.2	0.6	GO:0035525	NF-kappaB p50/p65 complex(GO:0035525)
0.2	3.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2	0.9	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2	3.6	GO:0042613	MHC class II protein complex(GO:0042613)
0.2	0.7	GO:0055087	Ski complex(GO:0055087)
0.1	1.2	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	1.3	GO:0032010	phagolysosome(GO:0032010)
0.1	1.7	GO:0097524	sperm plasma membrane(GO:0097524)
0.1	0.9	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1	0.3	GO:0005668	RNA polymerase transcription factor SL1 complex(GO:0005668)
0.1	0.8	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.1	0.6	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.1	1.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.3	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.9	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	1.3	GO:0005642	annulate lamellae(GO:0005642)
0.1	0.3	GO:0032173	septin ring(GO:0005940) septin collar(GO:0032173)
0.1	2.5	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.1	10.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	0.5	GO:0061689	tricellular tight junction(GO:0061689)
0.1	3.6	GO:0030057	desmosome(GO:0030057)
0.1	9.7	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	0.6	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1	0.9	GO:0097443	sorting endosome(GO:0097443)
0.1	0.7	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.1	0.8	GO:0016013	syntrophin complex(GO:0016013)
0.1	0.5	GO:0070876	SOSS complex(GO:0070876)
0.1	2.3	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	1.0	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1	0.4	GO:0031673	H zone(GO:0031673)
0.1	0.2	GO:0034515	proteasome storage granule(GO:0034515)
0.1	2.7	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	2.4	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	0.3	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1	1.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	0.2	GO:0070522	ERCC4-ERCC1 complex(GO:0070522)
0.0	0.3	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.5	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.8	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.3	GO:1903440	calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0	0.2	GO:0071006	U2-type catalytic step 1 spliceosome(GO:0071006)
0.0	1.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	1.2	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	3.6	GO:0070821	tertiary granule membrane(GO:0070821)
0.0	1.4	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.2	GO:0010370	perinucleolar chromocenter(GO:0010370)
0.0	0.3	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.9	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	4.9	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.6	GO:0000815	ESCRT III complex(GO:0000815)
0.0	2.5	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	1.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.4	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.7	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.5	GO:0005869	dynactin complex(GO:0005869)
0.0	1.2	GO:0042629	mast cell granule(GO:0042629)
0.0	12.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.3	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.6	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	0.9	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0	0.6	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.6	GO:0042555	MCM complex(GO:0042555)
0.0	0.2	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.0	0.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.2	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.6	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)
0.0	3.0	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.1	GO:0071148	TEAD-1-YAP complex(GO:0071148)
0.0	0.3	GO:0042587	glycogen granule(GO:0042587)
0.0	1.7	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.4	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.5	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	1.6	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	0.3	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.6	GO:0030014	CCR4-NOT complex(GO:0030014)
0.0	0.3	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	1.9	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	0.6	GO:0031305	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0	2.5	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	5.2	GO:0043209	myelin sheath(GO:0043209)
0.0	4.6	GO:0034774	secretory granule lumen(GO:0034774)
0.0	0.3	GO:0098793	presynapse(GO:0098793)
0.0	2.6	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	0.9	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	2.8	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.0	0.1	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0	0.4	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0035061	interchromatin granule(GO:0035061)
0.0	0.7	GO:0005771	multivesicular body(GO:0005771)
0.0	1.1	GO:0044439	microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0	1.4	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	0.9	GO:0043195	terminal bouton(GO:0043195)
0.0	1.5	GO:0072562	blood microparticle(GO:0072562)
0.0	0.1	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.4	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.9	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	0.4	GO:0044447	axoneme part(GO:0044447)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.8	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	3.2	GO:0001726	ruffle(GO:0001726)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.6	4.7	GO:0002113	interleukin-33 binding(GO:0002113)
1.4	5.5	GO:0047860	diiodophenylpyruvate reductase activity(GO:0047860)
0.9	2.7	GO:0016964	alpha-2 macroglobulin receptor activity(GO:0016964)
0.8	2.4	GO:0097258	tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.7	3.0	GO:0036134	thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.7	2.2	GO:0004397	histidine ammonia-lyase activity(GO:0004397)
0.6	4.3	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.6	4.9	GO:0005124	N-formyl peptide receptor activity(GO:0004982) scavenger receptor binding(GO:0005124)
0.6	3.5	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.5	2.4	GO:0051916	granulocyte colony-stimulating factor binding(GO:0051916)
0.4	2.2	GO:0003989	acetyl-CoA carboxylase activity(GO:0003989)
0.4	1.5	GO:0052642	lysophosphatidic acid phosphatase activity(GO:0052642)
0.3	1.4	GO:0004492	methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.3	7.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.3	3.1	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.3	1.2	GO:0051765	inositol tetrakisphosphate kinase activity(GO:0051765)
0.3	1.2	GO:0004057	arginyltransferase activity(GO:0004057)
0.3	2.1	GO:0070568	guanylyltransferase activity(GO:0070568)
0.3	0.9	GO:0070538	oleic acid binding(GO:0070538)
0.3	1.2	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.3	1.1	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.3	0.8	GO:0097689	iron channel activity(GO:0097689)
0.2	1.2	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.2	3.1	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.2	1.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.2	2.7	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.2	0.9	GO:0097363	protein O-GlcNAc transferase activity(GO:0097363)
0.2	2.3	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2	1.9	GO:0050692	DBD domain binding(GO:0050692)
0.2	1.4	GO:0099580	ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2	1.0	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.2	4.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2	0.7	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.2	0.9	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.2	3.0	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.2	0.9	GO:0052836	inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.2	0.5	GO:0015228	coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2	0.5	GO:0004853	uroporphyrinogen decarboxylase activity(GO:0004853)
0.2	1.6	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.2	0.5	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.2	0.9	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1	1.6	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1	1.2	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1	1.1	GO:0004064	arylesterase activity(GO:0004064)
0.1	1.5	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.6	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.1	2.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	1.3	GO:0045029	UDP-activated nucleotide receptor activity(GO:0045029)
0.1	2.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.1	1.3	GO:0055104	ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1	1.3	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1	3.8	GO:0017127	cholesterol transporter activity(GO:0017127)
0.1	0.8	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.1	1.1	GO:0042610	CD8 receptor binding(GO:0042610)
0.1	2.2	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
0.1	2.3	GO:0003993	acid phosphatase activity(GO:0003993)
0.1	0.9	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1	2.4	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1	2.6	GO:0042301	phosphate ion binding(GO:0042301)
0.1	0.7	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.1	2.0	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.1	2.1	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	1.4	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1	0.4	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.1	1.3	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	0.7	GO:0015057	thrombin receptor activity(GO:0015057)
0.1	0.6	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1	2.9	GO:0042605	peptide antigen binding(GO:0042605)
0.1	0.5	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.1	0.7	GO:0046790	virion binding(GO:0046790)
0.1	0.3	GO:0004917	interleukin-7 receptor activity(GO:0004917)
0.1	1.4	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	0.2	GO:0050146	nucleoside phosphotransferase activity(GO:0050146)
0.1	0.2	GO:0015432	bile acid-exporting ATPase activity(GO:0015432)
0.1	0.4	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1	0.5	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	0.5	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.1	5.4	GO:0015026	coreceptor activity(GO:0015026)
0.1	1.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.1	0.5	GO:0050119	N-acetylglucosamine deacetylase activity(GO:0050119)
0.1	0.2	GO:0030366	molybdopterin synthase activity(GO:0030366)
0.1	1.3	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	0.7	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.1	0.6	GO:0071532	ankyrin repeat binding(GO:0071532)
0.1	1.5	GO:0017070	U6 snRNA binding(GO:0017070)
0.1	2.7	GO:0001848	complement binding(GO:0001848)
0.1	0.5	GO:0034046	poly(G) binding(GO:0034046)
0.1	3.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	0.8	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	0.5	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	2.3	GO:0004383	guanylate cyclase activity(GO:0004383)
0.1	0.7	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.1	0.7	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1	0.3	GO:0004556	alpha-amylase activity(GO:0004556)
0.1	0.3	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1	0.6	GO:0045545	syndecan binding(GO:0045545)
0.1	0.9	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.1	0.9	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1	0.4	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1	0.5	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1	1.2	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1	0.5	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1	0.3	GO:0004991	parathyroid hormone receptor activity(GO:0004991)
0.1	0.5	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1	1.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.1	1.2	GO:0043422	protein kinase B binding(GO:0043422)
0.1	0.4	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.1	1.7	GO:0019992	diacylglycerol binding(GO:0019992)
0.1	0.6	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1	0.5	GO:0016167	glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0	3.0	GO:0050699	WW domain binding(GO:0050699)
0.0	1.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	1.4	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	1.5	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	2.4	GO:0042287	MHC protein binding(GO:0042287)
0.0	0.3	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.8	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.7	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.6	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	10.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	1.0	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.8	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.5	GO:1901611	phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0	0.8	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	1.7	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	1.5	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	2.3	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.4	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.3	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	1.0	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.6	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.6	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.2	GO:0008665	2'-phosphotransferase activity(GO:0008665)
0.0	1.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	3.3	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.6	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.4	GO:0019864	IgG binding(GO:0019864)
0.0	0.9	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.5	GO:0032052	bile acid binding(GO:0032052)
0.0	0.2	GO:0051021	GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.8	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.5	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)
0.0	0.2	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.3	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.5	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	1.6	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.7	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.2	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
0.0	0.9	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.4	GO:0019826	oxygen sensor activity(GO:0019826)
0.0	0.6	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.8	GO:0051787	misfolded protein binding(GO:0051787)
0.0	1.0	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.3	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.7	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.9	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0	1.1	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.3	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.5	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.4	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.6	GO:0005351	sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0	1.9	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.2	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.8	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.3	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.6	GO:0005123	death receptor binding(GO:0005123)
0.0	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.3	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.3	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.2	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.2	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0	0.3	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	0.7	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.9	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.0	0.7	GO:0002020	protease binding(GO:0002020)
0.0	0.2	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	6.4	GO:0030246	carbohydrate binding(GO:0030246)
0.0	0.6	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.8	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.7	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	0.1	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.6	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.3	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	1.2	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.8	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	0.1	GO:0004096	catalase activity(GO:0004096)
0.0	1.0	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	0.5	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.3	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.0	0.4	GO:0031078	NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) NAD-dependent protein deacetylase activity(GO:0034979)
0.0	0.1	GO:0033188	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0	0.1	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.3	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.5	GO:0001618	virus receptor activity(GO:0001618)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	PID ALK2 PATHWAY	ALK2 signaling events
0.1	4.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	5.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	7.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	4.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	2.8	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	3.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	1.6	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	1.7	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	1.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.9	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	1.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	3.9	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.8	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.9	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	1.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	1.9	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.2	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	1.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	2.9	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.6	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	1.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	1.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.7	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	1.0	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.7	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	1.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.3	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.9	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	1.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.8	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.7	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.7	PID BMP PATHWAY	BMP receptor signaling
0.0	1.4	PID E2F PATHWAY	E2F transcription factor network
0.0	1.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	1.4	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.5	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.3	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.3	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.6	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.2	1.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	4.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	3.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	3.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	1.5	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	1.6	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	7.8	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	2.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.1	4.7	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	3.5	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.1	2.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	11.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.1	4.7	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	1.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	5.2	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	2.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	1.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	1.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.6	REACTOME OPSINS	Genes involved in Opsins
0.0	1.0	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	2.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	1.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	3.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.4	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	1.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.6	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	1.3	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	0.6	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	1.3	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0	0.8	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.9	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	1.4	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.5	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	2.0	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.0	0.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	1.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.7	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.6	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	5.7	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.0	0.8	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.0	0.6	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.9	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	2.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.3	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	1.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.5	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.8	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.3	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	1.2	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	1.3	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.5	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.6	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	1.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.5	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.4	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.6	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.3	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.3	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.8	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.9	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.6	REACTOME CELL CELL JUNCTION ORGANIZATION	Genes involved in Cell-cell junction organization
0.0	0.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	1.4	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	0.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.1	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.0	0.3	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Results for TLX2

Z-value: 2.21

Motif logo

Transcription factors associated with TLX2

Activity-expression correlation:

Activity profile of TLX2 motif

Sorted Z-values of TLX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: