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Illumina Body Map 2: averaged replicates
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Results for TLX2
Z-value: 2.21
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Transcription factors associated with TLX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TLX2 | hg19_v2_chr2_+_74741569_74741620 | -0.55 | 1.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_117085336 Show fit | 4.48 |
ENST00000259396.8
ENST00000538816.1 |
orosomucoid 1 |
|
| chr7_-_99573677 Show fit | 3.50 |
ENST00000292401.4
|
alpha-2-glycoprotein 1, zinc-binding |
|
| chr7_-_99573640 Show fit | 3.31 |
ENST00000411734.1
|
alpha-2-glycoprotein 1, zinc-binding |
|
| chr19_+_52264104 Show fit | 3.22 |
ENST00000340023.6
|
formyl peptide receptor 2 |
|
| chr19_+_7733929 Show fit | 3.17 |
ENST00000221515.2
|
resistin |
|
| chr9_+_117092149 Show fit | 3.02 |
ENST00000431067.2
ENST00000412657.1 |
orosomucoid 2 |
|
| chr1_+_57320437 Show fit | 2.51 |
ENST00000361249.3
|
complement component 8, alpha polypeptide |
|
| chr6_-_49712147 Show fit | 2.50 |
ENST00000433368.2
ENST00000354620.4 |
cysteine-rich secretory protein 3 |
|
| chr6_-_49712123 Show fit | 2.46 |
ENST00000263045.4
|
cysteine-rich secretory protein 3 |
|
| chr1_-_36947120 Show fit | 2.44 |
ENST00000361632.4
|
colony stimulating factor 3 receptor (granulocyte) |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.1 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.6 | 7.5 | GO:1904469 | positive regulation of tumor necrosis factor secretion(GO:1904469) |
| 0.2 | 6.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.3 | 5.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 5.5 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.1 | 4.9 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.7 | 4.7 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.3 | 4.5 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.0 | 4.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 3.8 | GO:0097186 | amelogenesis(GO:0097186) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 12.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 10.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 9.7 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 5.2 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 4.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 4.6 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.4 | 4.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 3.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 3.6 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 7.2 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 6.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.4 | 5.5 | GO:0047860 | diiodophenylpyruvate reductase activity(GO:0047860) |
| 0.1 | 5.4 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.6 | 4.9 | GO:0005124 | N-formyl peptide receptor activity(GO:0004982) scavenger receptor binding(GO:0005124) |
| 1.6 | 4.7 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.6 | 4.3 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.2 | 4.1 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.1 | 3.8 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.0 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 3.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 3.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 3.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 2.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 7.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 5.7 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 5.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 4.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 4.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.2 | 4.6 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 4.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 3.6 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 3.5 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |