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Illumina Body Map 2: averaged replicates
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Results for TP53
Z-value: 1.95
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Transcription factors associated with TP53
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP53 | hg19_v2_chr17_-_7590745_7590856 | 0.39 | 2.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_89417335 Show fit | 4.57 |
ENST00000490686.1
|
immunoglobulin kappa variable 1-17 |
|
| chr8_+_22960426 Show fit | 4.13 |
ENST00000540813.1
|
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
|
| chr14_-_106692191 Show fit | 3.92 |
ENST00000390607.2
|
immunoglobulin heavy variable 3-21 |
|
| chr19_+_827823 Show fit | 2.75 |
ENST00000233997.2
|
azurocidin 1 |
|
| chr19_-_6591113 Show fit | 2.68 |
ENST00000423145.3
ENST00000245903.3 |
CD70 molecule |
|
| chr6_+_36098262 Show fit | 2.57 |
ENST00000373761.6
ENST00000373766.5 |
mitogen-activated protein kinase 13 |
|
| chr11_+_289110 Show fit | 2.51 |
ENST00000409548.2
|
ATH1, acid trehalase-like 1 (yeast) |
|
| chr11_+_289155 Show fit | 2.46 |
ENST00000409655.1
|
ATH1, acid trehalase-like 1 (yeast) |
|
| chr8_-_23021533 Show fit | 2.45 |
ENST00000312584.3
|
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
|
| chr11_-_47400078 Show fit | 2.30 |
ENST00000378538.3
|
spleen focus forming virus (SFFV) proviral integration oncogene |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP53
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 8.9 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.1 | 8.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 6.1 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.0 | 5.2 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) |
| 0.0 | 5.1 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
| 0.2 | 4.8 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 1.2 | 4.6 | GO:0071613 | granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) |
| 0.3 | 4.3 | GO:0022417 | protein maturation by protein folding(GO:0022417) |
| 0.9 | 3.5 | GO:0042247 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 0.3 | 3.5 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.2 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 4.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 4.3 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 0.1 | 3.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 3.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 3.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.7 | 3.5 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.0 | 3.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 3.2 | GO:0031527 | filopodium membrane(GO:0031527) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 11.4 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.7 | 8.9 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 6.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 6.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 4.6 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.3 | 4.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 3.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 3.7 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.0 | 3.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.4 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 9.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 5.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 4.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 3.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 3.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 3.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.1 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 5.2 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.2 | 4.8 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 4.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 4.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 3.9 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 3.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 3.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.0 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.1 | 2.4 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |