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Illumina Body Map 2: averaged replicates
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Results for UCCAGUU
Z-value: 1.91
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miRNA associated with seed UCCAGUU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_28338732 Show fit | 3.23 |
ENST00000284987.5
|
ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
|
| chr7_+_114562172 Show fit | 2.38 |
ENST00000393486.1
ENST00000257724.3 |
MyoD family inhibitor domain containing |
|
| chr3_+_30648066 Show fit | 2.33 |
ENST00000359013.4
|
transforming growth factor, beta receptor II (70/80kDa) |
|
| chr11_+_128563652 Show fit | 2.28 |
ENST00000527786.2
|
Fli-1 proto-oncogene, ETS transcription factor |
|
| chr11_-_86666427 Show fit | 2.14 |
ENST00000531380.1
|
frizzled family receptor 4 |
|
| chr1_-_21671968 Show fit | 2.13 |
ENST00000415912.2
|
endothelin converting enzyme 1 |
|
| chr1_-_119532127 Show fit | 2.12 |
ENST00000207157.3
|
T-box 15 |
|
| chr2_+_121103706 Show fit | 1.90 |
ENST00000295228.3
|
inhibin, beta B |
|
| chr11_+_111473108 Show fit | 1.86 |
ENST00000304987.3
|
salt-inducible kinase 2 |
|
| chr11_+_76494253 Show fit | 1.86 |
ENST00000333090.4
|
tsukushi, small leucine rich proteoglycan |
Network of associatons between targets according to the STRING database.
First level regulatory network of UCCAGUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.2 | GO:0044691 | tooth eruption(GO:0044691) |
| 0.0 | 2.7 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.8 | 2.3 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 0.8 | 2.3 | GO:0060435 | bronchiole development(GO:0060435) |
| 0.1 | 2.3 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.2 | 2.2 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.7 | 2.1 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.4 | 2.1 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 0.4 | 2.1 | GO:0034959 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.0 | 2.0 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.9 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 2.2 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.4 | 2.1 | GO:0031302 | intrinsic component of endosome membrane(GO:0031302) |
| 0.4 | 2.1 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 2.1 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 1.8 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 1.8 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.6 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 4.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 3.1 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 3.1 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 2.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.6 | 2.3 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.0 | 2.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 2.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 2.1 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.4 | 1.8 | GO:0051765 | inositol tetrakisphosphate kinase activity(GO:0051765) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 4.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 4.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 2.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 2.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 2.8 | REACTOME GAP JUNCTION TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.1 | 2.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 1.9 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 1.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.6 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 1.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.5 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 1.5 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |