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Illumina Body Map 2: averaged replicates
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Results for WT1_MTF1_ZBTB7B
Z-value: 3.54
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Transcription factors associated with WT1_MTF1_ZBTB7B
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000184937.8 | WT1 transcription factor | |
| ENSG00000188786.9 | metal regulatory transcription factor 1 | |
| ENSG00000160685.9 | zinc finger and BTB domain containing 7B |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB7B | hg19_v2_chr1_+_154975110_154975149 | -0.66 | 3.6e-05 | Click! |
| MTF1 | hg19_v2_chr1_-_38325256_38325292 | -0.33 | 6.2e-02 | Click! |
| WT1 | hg19_v2_chr11_-_32452357_32452363 | 0.31 | 8.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_819901 Show fit | 21.62 |
ENST00000304062.6
|
complexin 1 |
|
| chr4_-_819880 Show fit | 20.51 |
ENST00000505203.1
|
complexin 1 |
|
| chr22_+_51112800 Show fit | 17.24 |
ENST00000414786.2
|
SH3 and multiple ankyrin repeat domains 3 |
|
| chr19_-_291365 Show fit | 14.12 |
ENST00000591572.1
ENST00000269812.3 ENST00000434325.2 |
phosphatidic acid phosphatase type 2C |
|
| chr16_+_87636474 Show fit | 14.07 |
ENST00000284262.2
|
junctophilin 3 |
|
| chr22_+_48972118 Show fit | 13.31 |
ENST00000358295.5
|
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 |
|
| chr14_+_102027688 Show fit | 12.97 |
ENST00000510508.4
ENST00000359323.3 |
deiodinase, iodothyronine, type III |
|
| chr17_+_30593195 Show fit | 12.57 |
ENST00000431505.2
ENST00000269051.4 ENST00000538145.1 |
rhomboid, veinlet-like 3 (Drosophila) |
|
| chr19_+_708910 Show fit | 12.49 |
ENST00000264560.7
|
paralemmin |
|
| chr19_+_709101 Show fit | 12.27 |
ENST00000338448.5
|
paralemmin |
Network of associatons between targets according to the STRING database.
First level regulatory network of WT1_MTF1_ZBTB7B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 57.3 | GO:0071805 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.9 | 51.3 | GO:0014047 | glutamate secretion(GO:0014047) |
| 1.0 | 49.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 6.1 | 48.9 | GO:1902613 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 0.6 | 48.6 | GO:0019226 | transmission of nerve impulse(GO:0019226) |
| 0.3 | 38.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 1.8 | 38.5 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.8 | 36.5 | GO:0035640 | exploration behavior(GO:0035640) |
| 2.7 | 35.1 | GO:0021894 | cerebral cortex GABAergic interneuron development(GO:0021894) |
| 1.8 | 35.1 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 179.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 110.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 105.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.6 | 96.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.3 | 84.0 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.6 | 78.8 | GO:0005604 | basement membrane(GO:0005604) |
| 0.5 | 73.7 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 72.9 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 70.0 | GO:0098793 | presynapse(GO:0098793) |
| 0.2 | 69.0 | GO:0043025 | neuronal cell body(GO:0043025) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 56.2 | GO:0005326 | neurotransmitter transporter activity(GO:0005326) |
| 0.5 | 54.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.7 | 53.5 | GO:0031005 | filamin binding(GO:0031005) |
| 0.4 | 53.4 | GO:0030276 | clathrin binding(GO:0030276) |
| 7.4 | 51.5 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.3 | 50.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 50.8 | GO:0005267 | potassium channel activity(GO:0005267) |
| 1.2 | 48.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917) |
| 0.3 | 47.2 | GO:0008201 | heparin binding(GO:0008201) |
| 0.4 | 40.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 176.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 103.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 54.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 48.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.6 | 47.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.8 | 45.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.5 | 42.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 39.8 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.3 | 37.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.5 | 35.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 87.1 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.8 | 68.3 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.9 | 64.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 1.0 | 53.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.0 | 48.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 1.2 | 45.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.1 | 39.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 1.6 | 35.9 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 1.1 | 32.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 32.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |