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Illumina Body Map 2: averaged replicates
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 4.68
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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000065978.13 | Y-box binding protein 1 | |
| ENSG00000170345.5 | Fos proto-oncogene, AP-1 transcription factor subunit | |
| ENSG00000066136.15 | nuclear transcription factor Y subunit gamma | |
| ENSG00000001167.10 | nuclear transcription factor Y subunit alpha | |
| ENSG00000120837.3 | nuclear transcription factor Y subunit beta | |
| ENSG00000115816.9 | CCAAT enhancer binding protein zeta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFYB | hg19_v2_chr12_-_104532062_104532071 | -0.42 | 1.6e-02 | Click! |
| NFYC | hg19_v2_chr1_+_41157421_41157510 | 0.28 | 1.2e-01 | Click! |
| NFYA | hg19_v2_chr6_+_41040678_41040722 | 0.19 | 3.0e-01 | Click! |
| YBX1 | hg19_v2_chr1_+_43148625_43148710 | -0.07 | 7.1e-01 | Click! |
| FOS | hg19_v2_chr14_+_75746664_75746683 | 0.05 | 7.7e-01 | Click! |
| CEBPZ | hg19_v2_chr2_-_37458749_37458856 | 0.05 | 7.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 15.6 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.2 | 11.1 | GO:0010965 | regulation of mitotic sister chromatid separation(GO:0010965) |
| 0.1 | 11.1 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.4 | 10.6 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.2 | 9.9 | GO:0043486 | histone exchange(GO:0043486) |
| 0.9 | 9.5 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.1 | 8.7 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.4 | 8.2 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.1 | 8.1 | GO:0006695 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.7 | 7.8 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.1 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 18.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.3 | 16.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 16.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 14.8 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 14.4 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 13.0 | GO:0005694 | chromosome(GO:0005694) |
| 0.1 | 12.6 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.2 | 12.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 11.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.4 | GO:0042393 | histone binding(GO:0042393) |
| 1.2 | 15.6 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.2 | 15.5 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 11.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 11.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.4 | 9.8 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 9.4 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.1 | 8.7 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 8.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.2 | 8.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.3 | 15.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 15.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 13.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 9.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 7.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 7.7 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 7.4 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.3 | 7.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.2 | 7.0 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.4 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.5 | 20.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 19.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.4 | 12.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.3 | 8.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 8.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 8.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 8.3 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.4 | 8.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 8.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |