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Illumina Body Map 2: averaged replicates
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Results for ZBTB14
Z-value: 1.88
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Transcription factors associated with ZBTB14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB14 | hg19_v2_chr18_-_5295679_5295734 | 0.20 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_133614467 Show fit | 3.74 |
ENST00000469959.1
|
RAB6B, member RAS oncogene family |
|
| chr3_-_133614597 Show fit | 3.24 |
ENST00000285208.4
ENST00000460865.3 |
RAB6B, member RAS oncogene family |
|
| chr3_-_133614421 Show fit | 2.97 |
ENST00000543906.1
|
RAB6B, member RAS oncogene family |
|
| chr14_+_92789498 Show fit | 2.67 |
ENST00000531433.1
|
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 |
|
| chr3_-_133614297 Show fit | 2.60 |
ENST00000486858.1
ENST00000477759.1 |
RAB6B, member RAS oncogene family |
|
| chr2_+_207308539 Show fit | 2.49 |
ENST00000374416.1
ENST00000374415.3 |
ADAM metallopeptidase domain 23 |
|
| chr16_+_56623433 Show fit | 2.48 |
ENST00000570176.1
|
metallothionein 3 |
|
| chr12_+_121078355 Show fit | 2.41 |
ENST00000316803.3
|
calcium binding protein 1 |
|
| chr16_+_6533729 Show fit | 2.29 |
ENST00000551752.1
|
RNA binding protein, fox-1 homolog (C. elegans) 1 |
|
| chr3_-_179754706 Show fit | 2.29 |
ENST00000465751.1
ENST00000467460.1 |
peroxisomal biogenesis factor 5-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB14
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.4 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.7 | 8.0 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.0 | 7.5 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.0 | 6.5 | GO:0046834 | lipid phosphorylation(GO:0046834) |
| 0.2 | 5.4 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.3 | 4.8 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 0.1 | 3.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 3.6 | GO:0097503 | sialylation(GO:0097503) |
| 1.2 | 3.5 | GO:0003168 | Purkinje myocyte differentiation(GO:0003168) cardiac pacemaker cell fate commitment(GO:0060927) atrioventricular node cell fate commitment(GO:0060929) |
| 0.9 | 3.5 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 9.2 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 8.7 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 5.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 5.6 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 4.5 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 4.5 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.4 | 4.2 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.0 | 4.2 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 4.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.6 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.4 | 12.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.8 | 8.0 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.0 | 6.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.2 | 6.1 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 5.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 4.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 4.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 1.0 | 4.1 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
| 0.3 | 4.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 5.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 5.0 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 4.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 4.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 3.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 3.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 3.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 2.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.7 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 6.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 6.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 5.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 5.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.9 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 4.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 4.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 3.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 3.3 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |