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Illumina Body Map 2: averaged replicates
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Results for ZBTB18
Z-value: 2.36
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Transcription factors associated with ZBTB18
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB18 | hg19_v2_chr1_+_244214577_244214593 | -0.29 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB18
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 2.0 | 16.0 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 4.8 | 14.3 | GO:1902362 | melanocyte apoptotic process(GO:1902362) |
| 0.2 | 10.9 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.4 | 10.0 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
| 3.2 | 9.6 | GO:0061033 | secretion by lung epithelial cell involved in lung growth(GO:0061033) |
| 0.4 | 9.1 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 8.3 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 1.1 | 7.9 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.8 | 7.1 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 22.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.8 | 14.3 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 10.9 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 8.5 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 8.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 7.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.5 | 7.1 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 6.8 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 6.7 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.4 | 14.3 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.3 | 10.9 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 10.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 8.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 7.9 | GO:0031005 | filamin binding(GO:0031005) |
| 0.3 | 7.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 6.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 6.7 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 6.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 25.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 8.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 7.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 6.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 6.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 6.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 4.8 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 0.1 | 4.7 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 4.2 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.0 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.1 | 8.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 6.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 6.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 6.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 4.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 4.4 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 4.2 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 3.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 3.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |