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Illumina Body Map 2: averaged replicates

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Results for ZBTB18

Z-value: 2.36

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Transcription factors associated with ZBTB18

Gene Symbol Gene ID Gene Info
ENSG00000179456.9 zinc finger and BTB domain containing 18

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB18hg19_v2_chr1_+_244214577_244214593-0.291.1e-01Click!

Activity profile of ZBTB18 motif

Sorted Z-values of ZBTB18 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_47653178 13.13 ENST00000328741.5
neurexophilin 3
chr1_-_168698433 10.93 ENST00000367817.3
dermatopontin
chr17_+_47653471 10.76 ENST00000513748.1
neurexophilin 3
chr19_+_11649532 10.05 ENST00000252456.2
ENST00000592923.1
ENST00000535659.2
calponin 1, basic, smooth muscle
chr4_+_15376165 9.02 ENST00000382383.3
ENST00000429690.1
C1q and tumor necrosis factor related protein 7
chr1_-_16344500 7.90 ENST00000406363.2
ENST00000411503.1
ENST00000545268.1
ENST00000487046.1
heat shock 27kDa protein family, member 7 (cardiovascular)
chr2_+_189839046 7.08 ENST00000304636.3
ENST00000317840.5
collagen, type III, alpha 1
chr11_-_68780824 6.95 ENST00000441623.1
ENST00000309099.6
MAS-related GPR, member F
chrX_+_99899180 5.70 ENST00000373004.3
sushi-repeat containing protein, X-linked 2
chr17_+_77020325 5.53 ENST00000311661.4
C1q and tumor necrosis factor related protein 1
chr17_+_77020224 5.51 ENST00000339142.2
C1q and tumor necrosis factor related protein 1
chr15_+_49715449 5.48 ENST00000560979.1
fibroblast growth factor 7
chr1_+_53527854 5.35 ENST00000371500.3
ENST00000395871.2
ENST00000312553.5
podocan
chr2_-_163099885 5.26 ENST00000443424.1
fibroblast activation protein, alpha
chr2_-_163100045 5.07 ENST00000188790.4
fibroblast activation protein, alpha
chr17_+_77020146 5.00 ENST00000579760.1
C1q and tumor necrosis factor related protein 1
chr14_-_38725573 4.81 ENST00000342213.2
C-type lectin domain family 14, member A
chr14_+_94577074 4.52 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
interferon, alpha-inducible protein 27
chrX_+_43515467 4.37 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr17_-_15168624 4.24 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
peripheral myelin protein 22
chr13_+_113777105 4.21 ENST00000409306.1
ENST00000375551.3
ENST00000375559.3
coagulation factor X
chr15_+_49715293 4.17 ENST00000267843.4
ENST00000560270.1
fibroblast growth factor 7
chr16_-_49698136 4.08 ENST00000535559.1
zinc finger protein 423
chr15_-_96590126 4.01 ENST00000561051.1
RP11-4G2.1
chr2_-_163099546 3.98 ENST00000447386.1
fibroblast activation protein, alpha
chr12_-_104443890 3.94 ENST00000547583.1
ENST00000360814.4
ENST00000546851.1
glycosyltransferase 8 domain containing 2
chr11_-_68780701 3.88 ENST00000320913.6
MAS-related GPR, member F
chr9_-_13165457 3.83 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
multiple PDZ domain protein
chr12_-_16762802 3.78 ENST00000534946.1
LIM domain only 3 (rhombotin-like 2)
chr9_+_72658490 3.77 ENST00000377182.4
MAM domain containing 2
chr12_+_2162447 3.71 ENST00000335762.5
ENST00000399655.1
calcium channel, voltage-dependent, L type, alpha 1C subunit
chrX_-_101771645 3.64 ENST00000289373.4
thymosin beta 15a
chr4_-_152149033 3.63 ENST00000514152.1
SH3 domain containing 19
chr1_-_156647189 3.58 ENST00000368223.3
nestin
chr11_+_76494253 3.56 ENST00000333090.4
tsukushi, small leucine rich proteoglycan
chr3_-_145940214 3.42 ENST00000481701.1
phospholipid scramblase 4
chr18_+_6834472 3.39 ENST00000581099.1
ENST00000419673.2
ENST00000531294.1
Rho GTPase activating protein 28
chr4_+_75480629 3.30 ENST00000380846.3
amphiregulin B
chr11_-_101454658 3.30 ENST00000344327.3
transient receptor potential cation channel, subfamily C, member 6
chr17_-_62050278 3.30 ENST00000578147.1
ENST00000435607.1
sodium channel, voltage-gated, type IV, alpha subunit
chr7_+_97361388 3.25 ENST00000350485.4
ENST00000346867.4
tachykinin, precursor 1
chr4_+_75310851 3.25 ENST00000395748.3
ENST00000264487.2
amphiregulin
chr17_+_32612687 3.17 ENST00000305869.3
chemokine (C-C motif) ligand 11
chr19_-_36001286 3.07 ENST00000602679.1
ENST00000492341.2
ENST00000472252.2
ENST00000602781.1
ENST00000402589.2
ENST00000458071.1
ENST00000436012.1
ENST00000443640.1
ENST00000450261.1
ENST00000467637.1
ENST00000480502.1
ENST00000474928.1
ENST00000414866.2
ENST00000392206.2
ENST00000488892.1
dermokine
chr8_-_49834299 3.03 ENST00000396822.1
snail family zinc finger 2
chr4_+_75311019 2.99 ENST00000502307.1
amphiregulin
chr3_-_145940126 2.93 ENST00000498625.1
phospholipid scramblase 4
chr8_-_17555164 2.89 ENST00000297488.6
microtubule associated tumor suppressor 1
chr1_+_19967014 2.88 ENST00000428975.1
neuroblastoma 1, DAN family BMP antagonist
chr8_+_1772132 2.86 ENST00000349830.3
ENST00000520359.1
ENST00000518288.1
ENST00000398560.1
Rho guanine nucleotide exchange factor (GEF) 10
chr12_+_26126681 2.76 ENST00000542865.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr13_-_28545276 2.66 ENST00000381020.7
caudal type homeobox 2
chr2_+_177053307 2.64 ENST00000331462.4
homeobox D1
chr7_+_97361218 2.63 ENST00000319273.5
tachykinin, precursor 1
chr1_+_78354175 2.60 ENST00000401035.3
ENST00000457030.1
ENST00000330010.8
nexilin (F actin binding protein)
chr1_+_78354330 2.59 ENST00000440324.1
nexilin (F actin binding protein)
chr19_-_36001113 2.58 ENST00000434389.1
dermokine
chr8_-_49833978 2.57 ENST00000020945.1
snail family zinc finger 2
chr20_+_56725952 2.50 ENST00000371168.3
chromosome 20 open reading frame 85
chr15_-_74043816 2.46 ENST00000379822.4
chromosome 15 open reading frame 59
chr2_-_65659762 2.45 ENST00000440972.1
sprouty-related, EVH1 domain containing 2
chr2_+_108994466 2.44 ENST00000272452.2
sulfotransferase family, cytosolic, 1C, member 4
chr3_+_100211412 2.40 ENST00000323523.4
ENST00000403410.1
ENST00000449609.1
transmembrane protein 45A
chr17_-_67138015 2.27 ENST00000284425.2
ENST00000590645.1
ATP-binding cassette, sub-family A (ABC1), member 6
chr19_-_36001386 2.25 ENST00000461300.1
dermokine
chr1_+_78354297 2.25 ENST00000334785.7
nexilin (F actin binding protein)
chr11_-_1606513 2.24 ENST00000382171.2
keratin associated protein 5-1
chr10_-_105437909 2.21 ENST00000540321.1
SH3 and PX domains 2A
chr8_+_24241969 2.18 ENST00000522298.1
ADAM-like, decysin 1
chr4_-_111563076 2.18 ENST00000354925.2
ENST00000511990.1
paired-like homeodomain 2
chr12_-_48119301 2.17 ENST00000545824.2
ENST00000422538.3
endonuclease, polyU-specific
chr5_+_140782351 2.17 ENST00000573521.1
protocadherin gamma subfamily A, 9
chr7_-_135433534 2.14 ENST00000338588.3
family with sequence similarity 180, member A
chr7_+_100770328 2.14 ENST00000223095.4
ENST00000445463.2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr6_-_163148700 2.13 ENST00000366894.1
ENST00000338468.3
parkin RBR E3 ubiquitin protein ligase
chr19_+_41119323 2.07 ENST00000599724.1
ENST00000597071.1
ENST00000243562.9
latent transforming growth factor beta binding protein 4
chr13_+_113699029 2.07 ENST00000423251.1
MCF.2 cell line derived transforming sequence-like
chr9_+_87283430 2.04 ENST00000376214.1
ENST00000376213.1
neurotrophic tyrosine kinase, receptor, type 2
chr13_-_33780133 2.02 ENST00000399365.3
StAR-related lipid transfer (START) domain containing 13
chr11_-_119252425 2.01 ENST00000260187.2
ubiquitin specific peptidase 2
chr8_+_24241789 2.01 ENST00000256412.4
ENST00000538205.1
ADAM-like, decysin 1
chr1_+_38022513 1.99 ENST00000296218.7
dynein, axonemal, light intermediate chain 1
chrX_-_153141302 1.93 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1 cell adhesion molecule
chrX_-_154563889 1.88 ENST00000369449.2
ENST00000321926.4
chloride intracellular channel 2
chr11_-_119252359 1.86 ENST00000455332.2
ubiquitin specific peptidase 2
chr15_+_51669444 1.84 ENST00000396399.2
gliomedin
chr1_+_38022572 1.84 ENST00000541606.1
dynein, axonemal, light intermediate chain 1
chr4_-_111563279 1.83 ENST00000511837.1
paired-like homeodomain 2
chr17_+_32582293 1.78 ENST00000580907.1
ENST00000225831.4
chemokine (C-C motif) ligand 2
chr19_+_54135310 1.76 ENST00000376650.1
divergent-paired related homeobox
chr17_+_48638371 1.71 ENST00000360761.4
ENST00000352832.5
ENST00000354983.4
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr9_+_97488939 1.71 ENST00000277198.2
ENST00000297979.5
chromosome 9 open reading frame 3
chr1_+_78354243 1.70 ENST00000294624.8
nexilin (F actin binding protein)
chr8_+_38965048 1.68 ENST00000399831.3
ENST00000437682.2
ENST00000519315.1
ENST00000379907.4
ENST00000522506.1
ADAM metallopeptidase domain 32
chr17_+_32597232 1.68 ENST00000378569.2
ENST00000200307.4
ENST00000394627.1
ENST00000394630.3
chemokine (C-C motif) ligand 7
chr19_+_7584088 1.55 ENST00000394341.2
zinc finger protein 358
chr11_-_33722286 1.54 ENST00000451594.2
ENST00000379011.4
chromosome 11 open reading frame 91
chr6_-_163148780 1.53 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
parkin RBR E3 ubiquitin protein ligase
chr16_-_18470696 1.49 ENST00000427999.2
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr12_-_48119340 1.48 ENST00000229003.3
endonuclease, polyU-specific
chr14_+_38033252 1.47 ENST00000554829.1
RP11-356O9.1
chr3_-_111314230 1.42 ENST00000317012.4
zinc finger, BED-type containing 2
chr11_+_4673716 1.40 ENST00000530215.1
olfactory receptor, family 51, subfamily E, member 1
chrX_+_103031758 1.38 ENST00000303958.2
ENST00000361621.2
proteolipid protein 1
chr12_-_16762971 1.37 ENST00000540590.1
LIM domain only 3 (rhombotin-like 2)
chr17_-_8263538 1.36 ENST00000535173.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr13_+_113698946 1.35 ENST00000397021.1
MCF.2 cell line derived transforming sequence-like
chr11_+_15136462 1.35 ENST00000379556.3
ENST00000424273.1
inscuteable homolog (Drosophila)
chr12_+_1738363 1.34 ENST00000397196.2
wingless-type MMTV integration site family, member 5B
chrX_-_153141434 1.33 ENST00000407935.2
ENST00000439496.1
L1 cell adhesion molecule
chr17_-_41174424 1.33 ENST00000355653.3
vesicle amine transport 1
chr17_+_36584662 1.32 ENST00000431231.2
ENST00000437668.3
Rho GTPase activating protein 23
chr11_+_63870660 1.28 ENST00000246841.3
fibronectin leucine rich transmembrane protein 1
chr5_-_180552304 1.24 ENST00000329365.2
olfactory receptor, family 2, subfamily V, member 1
chrX_-_110513703 1.24 ENST00000324068.1
calpain 6
chr17_-_19651668 1.23 ENST00000494157.2
ENST00000225740.6
aldehyde dehydrogenase 3 family, member A1
chr12_+_77718388 1.21 ENST00000550042.1
RP1-34H18.1
chr7_-_135433460 1.17 ENST00000415751.1
family with sequence similarity 180, member A
chr11_-_57089774 1.15 ENST00000527207.1
tankyrase 1 binding protein 1, 182kDa
chr16_+_28914680 1.14 ENST00000564112.1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr17_-_41174367 1.13 ENST00000587173.1
vesicle amine transport 1
chr3_+_159570722 1.13 ENST00000482804.1
schwannomin interacting protein 1
chr11_+_71900703 1.13 ENST00000393681.2
folate receptor 1 (adult)
chr5_+_140792614 1.13 ENST00000398610.2
protocadherin gamma subfamily A, 10
chr1_-_207206092 1.12 ENST00000359470.5
ENST00000461135.2
chromosome 1 open reading frame 116
chrX_+_103031421 1.09 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
proteolipid protein 1
chr2_+_33359687 1.09 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
latent transforming growth factor beta binding protein 1
chr17_-_19651654 1.07 ENST00000395555.3
aldehyde dehydrogenase 3 family, member A1
chr11_+_32112431 1.07 ENST00000054950.3
reticulocalbin 1, EF-hand calcium binding domain
chr3_-_105588231 1.05 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr2_+_90139056 1.04 ENST00000492446.1
immunoglobulin kappa variable 1D-16
chr12_-_54121261 1.03 ENST00000549784.1
ENST00000262059.4
calcium binding and coiled-coil domain 1
chr1_+_37947257 1.01 ENST00000471012.1
zinc finger CCCH-type containing 12A
chr9_+_118916082 1.00 ENST00000328252.3
pregnancy-associated plasma protein A, pappalysin 1
chr2_+_33359646 0.98 ENST00000390003.4
ENST00000418533.2
latent transforming growth factor beta binding protein 1
chr12_-_102874102 0.96 ENST00000392905.2
insulin-like growth factor 1 (somatomedin C)
chr11_-_57089671 0.96 ENST00000532437.1
tankyrase 1 binding protein 1, 182kDa
chr11_+_5602107 0.93 ENST00000345043.2
olfactory receptor, family 52, subfamily B, member 6
chr8_-_11058847 0.90 ENST00000297303.4
ENST00000416569.2
XK, Kell blood group complex subunit-related family, member 6
chr19_+_38880695 0.88 ENST00000587947.1
ENST00000338502.4
sprouty-related, EVH1 domain containing 3
chr12_-_56121612 0.88 ENST00000546939.1
CD63 molecule
chr10_-_95241951 0.85 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
myoferlin
chr18_+_3448455 0.82 ENST00000549780.1
TGFB-induced factor homeobox 1
chr12_-_56121580 0.78 ENST00000550776.1
CD63 molecule
chr11_-_40315640 0.78 ENST00000278198.2
leucine rich repeat containing 4C
chr6_-_39197226 0.75 ENST00000359534.3
potassium channel, subfamily K, member 5
chr3_+_121311966 0.75 ENST00000338040.4
F-box protein 40
chr10_-_95242044 0.75 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
myoferlin
chr8_-_37411648 0.74 ENST00000519738.1
RP11-150O12.1
chr12_-_11175219 0.72 ENST00000390673.2
taste receptor, type 2, member 19
chr2_-_89399845 0.68 ENST00000479981.1
immunoglobulin kappa variable 1-16
chr6_-_30523865 0.65 ENST00000433809.1
guanine nucleotide binding protein-like 1
chr1_-_11907829 0.64 ENST00000376480.3
natriuretic peptide A
chr11_+_5841544 0.64 ENST00000317037.2
olfactory receptor, family 52, subfamily N, member 2
chr19_+_39903185 0.62 ENST00000409794.3
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr11_-_63684316 0.61 ENST00000301459.4
REST corepressor 2
chr7_-_156803329 0.60 ENST00000252971.6
motor neuron and pancreas homeobox 1
chr3_-_114035026 0.54 ENST00000570269.1
RP11-553L6.5
chr2_+_29341037 0.54 ENST00000449202.1
CAP-GLY domain containing linker protein family, member 4
chr19_+_50084561 0.53 ENST00000246794.5
proline rich Gla (G-carboxyglutamic acid) 2
chr1_-_32210275 0.53 ENST00000440175.2
brain-specific angiogenesis inhibitor 2
chr14_-_61748550 0.50 ENST00000555868.1
transmembrane protein 30B
chr15_+_51669513 0.50 ENST00000558426.1
gliomedin
chr1_-_113160826 0.50 ENST00000538187.1
ENST00000369664.1
suppression of tumorigenicity 7 like
chr15_-_43559055 0.50 ENST00000220420.5
ENST00000349114.4
transglutaminase 5
chr10_+_97733786 0.49 ENST00000371198.2
coiled-coil and C2 domain containing 2B
chr19_-_13947099 0.47 ENST00000587762.1
microRNA 24-2
chr11_-_5810046 0.46 ENST00000317078.1
olfactory receptor, family 52, subfamily N, member 1
chr4_+_144312659 0.45 ENST00000509992.1
GRB2-associated binding protein 1
chr14_+_67707826 0.44 ENST00000261681.4
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr2_+_33359473 0.43 ENST00000432635.1
latent transforming growth factor beta binding protein 1
chr15_+_47631257 0.42 ENST00000560636.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr6_+_163148973 0.40 ENST00000366888.2
PARK2 co-regulated
chr10_-_123357598 0.38 ENST00000358487.5
ENST00000369058.3
ENST00000369060.4
ENST00000359354.2
fibroblast growth factor receptor 2
chr12_-_56122220 0.38 ENST00000552692.1
CD63 molecule
chr17_-_19651598 0.37 ENST00000570414.1
aldehyde dehydrogenase 3 family, member A1
chr20_+_57875658 0.36 ENST00000371025.3
endothelin 3
chr10_-_71332994 0.36 ENST00000242462.4
neurogenin 3
chr3_-_99245957 0.35 ENST00000484675.1
RP11-779P15.2
chr9_+_131683174 0.35 ENST00000372592.3
ENST00000428610.1
phytanoyl-CoA dioxygenase domain containing 1
chr15_-_74501310 0.32 ENST00000423167.2
ENST00000432245.2
stimulated by retinoic acid 6
chr12_-_56122124 0.30 ENST00000552754.1
CD63 molecule
chr11_+_5905501 0.28 ENST00000316987.2
olfactory receptor, family 52, subfamily E, member 4
chr17_+_19282064 0.26 ENST00000603493.1
mitogen-activated protein kinase 7
chr2_-_89417335 0.26 ENST00000490686.1
immunoglobulin kappa variable 1-17
chr2_+_201994042 0.26 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chr15_+_67418047 0.25 ENST00000540846.2
SMAD family member 3
chr19_+_48673949 0.25 ENST00000328759.7
chromosome 19 open reading frame 68
chr2_-_89597542 0.24 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr2_+_89923550 0.22 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr15_-_31453359 0.21 ENST00000542188.1
transient receptor potential cation channel, subfamily M, member 1
chr11_+_5509915 0.19 ENST00000322641.5
olfactory receptor, family 52, subfamily D, member 1
chr17_+_64961026 0.18 ENST00000262138.3
calcium channel, voltage-dependent, gamma subunit 4
chr16_+_14564842 0.17 ENST00000599734.1
AC092291.2
chr20_+_30467600 0.17 ENST00000375934.4
ENST00000375922.4
tubulin tyrosine ligase-like family, member 9
chr19_-_15918936 0.17 ENST00000334920.2
olfactory receptor, family 10, subfamily H, member 1
chr8_+_38662960 0.16 ENST00000524193.1
transforming, acidic coiled-coil containing protein 1
chr1_+_42619070 0.16 ENST00000372581.1
guanylate cyclase activator 2B (uroguanylin)
chr1_+_248651885 0.16 ENST00000366473.2
olfactory receptor, family 2, subfamily T, member 5
chr19_+_9203855 0.16 ENST00000429566.3
olfactory receptor, family 1, subfamily M, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB18

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 GO:1902362 melanocyte apoptotic process(GO:1902362)
3.2 9.6 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
2.0 16.0 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
2.0 5.9 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
1.9 5.6 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.1 7.9 GO:1903575 cornified envelope assembly(GO:1903575)
0.9 3.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.8 3.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.8 4.0 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.8 7.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 2.1 GO:0001300 chronological cell aging(GO:0001300)
0.6 0.6 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.6 3.2 GO:0035962 response to interleukin-13(GO:0035962)
0.6 6.2 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.6 1.8 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.6 2.9 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.6 2.8 GO:0034334 adherens junction maintenance(GO:0034334)
0.5 4.2 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.4 3.7 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.4 10.0 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.4 1.1 GO:0031446 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.4 1.1 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.4 5.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.4 2.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.4 9.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.3 1.7 GO:0086045 membrane depolarization during AV node cell action potential(GO:0086045)
0.3 2.0 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.3 2.0 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.3 1.0 GO:2000625 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.3 5.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.3 2.2 GO:0072675 osteoclast fusion(GO:0072675)
0.3 4.4 GO:0042420 dopamine catabolic process(GO:0042420)
0.3 2.7 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 6.4 GO:0017121 phospholipid scrambling(GO:0017121)
0.2 1.7 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2 2.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 4.2 GO:0032060 bleb assembly(GO:0032060)
0.2 10.9 GO:0030199 collagen fibril organization(GO:0030199)
0.2 3.9 GO:0045475 locomotor rhythm(GO:0045475)
0.2 1.0 GO:1904073 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.2 2.5 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.2 23.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 3.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.4 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.1 0.4 GO:0060615 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.1 5.0 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 3.6 GO:1901881 positive regulation of protein depolymerization(GO:1901881)
0.1 2.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 2.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 2.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 1.6 GO:0001778 plasma membrane repair(GO:0001778)
0.1 1.9 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 1.3 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.3 GO:0070376 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.1 2.9 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1 2.4 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.1 4.5 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.1 5.9 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 4.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 3.3 GO:0019228 neuronal action potential(GO:0019228)
0.1 0.3 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 1.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.2 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.1 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.0 0.6 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 1.0 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.0 0.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.5 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 1.4 GO:0030252 growth hormone secretion(GO:0030252)
0.0 1.0 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 3.9 GO:0000271 polysaccharide biosynthetic process(GO:0000271)
0.0 1.5 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.4 GO:0060290 transdifferentiation(GO:0060290)
0.0 8.3 GO:0006986 response to unfolded protein(GO:0006986)
0.0 2.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.1 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.0 0.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 2.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.3 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.3 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0014826 cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826)
0.0 0.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.6 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.4 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 1.4 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 2.0 GO:0030449 regulation of complement activation(GO:0030449)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.3 GO:0071438 invadopodium membrane(GO:0071438)
0.5 7.1 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 3.3 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 8.5 GO:0043218 compact myelin(GO:0043218)
0.2 3.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 27.4 GO:0005581 collagen trimer(GO:0005581)
0.2 5.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.2 2.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 3.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.0 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 2.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 7.9 GO:0016235 aggresome(GO:0016235)
0.1 0.3 GO:0035841 new growing cell tip(GO:0035841)
0.1 6.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 2.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 2.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 3.8 GO:0030286 dynein complex(GO:0030286)
0.0 1.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 4.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 22.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 10.9 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.5 GO:0043209 myelin sheath(GO:0043209)
0.0 8.3 GO:0030018 Z disc(GO:0030018)
0.0 2.2 GO:0002102 podosome(GO:0002102)
0.0 6.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.0 GO:0005811 lipid particle(GO:0005811)
0.0 2.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 6.2 GO:0005925 focal adhesion(GO:0005925)
0.0 6.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 5.8 GO:0060076 excitatory synapse(GO:0060076)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 2.1 GO:0043231 intracellular membrane-bounded organelle(GO:0043231)
0.0 2.5 GO:0005938 cell cortex(GO:0005938)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 1.6 GO:0005813 centrosome(GO:0005813)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.6 3.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.6 2.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.6 5.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5 4.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 2.5 GO:0050436 microfibril binding(GO:0050436)
0.4 14.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.4 1.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 2.0 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.3 7.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 10.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 2.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.3 1.1 GO:0061714 folic acid receptor activity(GO:0061714)
0.3 6.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 7.9 GO:0031005 filamin binding(GO:0031005)
0.2 1.7 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 2.9 GO:0016015 morphogen activity(GO:0016015)
0.2 3.6 GO:0019215 intermediate filament binding(GO:0019215)
0.2 2.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 3.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 3.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 2.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 21.6 GO:0005518 collagen binding(GO:0005518)
0.1 6.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 2.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 4.5 GO:0005521 lamin binding(GO:0005521)
0.1 3.0 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 3.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 6.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 2.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 2.1 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.1 2.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 8.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 4.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 6.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 2.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.7 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 10.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.8 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 6.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.5 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.5 GO:0019838 growth factor binding(GO:0019838)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 2.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 3.3 PID EPO PATHWAY EPO signaling pathway
0.1 3.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 28.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.1 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 4.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 8.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 25.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.7 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 3.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 3.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 1.8 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 3.0 PID SHP2 PATHWAY SHP2 signaling
0.0 6.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.1 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.0 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 6.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID FGF PATHWAY FGF signaling pathway
0.0 4.8 NABA MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.0 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.2 4.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 3.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 4.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 6.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 8.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 6.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 2.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 3.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 4.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 3.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 6.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 3.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation