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Illumina Body Map 2: averaged replicates
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Results for ZEB1
Z-value: 5.81
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31608054_31608156 | -0.05 | 7.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 66.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.5 | 54.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.6 | 54.3 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 6.6 | 45.9 | GO:0060671 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.2 | 41.9 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 1.6 | 29.7 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 4.0 | 23.9 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 1.6 | 23.4 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.3 | 19.8 | GO:0055078 | sodium ion homeostasis(GO:0055078) |
| 1.5 | 19.5 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 206.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 190.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 2.3 | 95.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 69.4 | GO:0070160 | occluding junction(GO:0070160) |
| 0.0 | 53.1 | GO:0005576 | extracellular region(GO:0005576) |
| 3.6 | 42.8 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.3 | 30.7 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.7 | 28.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 27.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 27.4 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 58.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 55.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 47.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 34.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.3 | 25.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.7 | 24.7 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 1.2 | 23.7 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.5 | 23.1 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.7 | 22.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.3 | 22.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 42.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 33.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 27.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 26.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 24.2 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.2 | 21.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 18.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 15.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 14.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.3 | 13.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 96.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 1.4 | 32.8 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 21.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 20.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 17.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.8 | 15.9 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.6 | 15.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.5 | 15.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 15.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.3 | 14.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |