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Illumina Body Map 2: averaged replicates
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Results for ZFX
Z-value: 3.92
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Transcription factors associated with ZFX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFX | hg19_v2_chrX_+_24167746_24167811 | 0.20 | 2.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.4 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 1.1 | 13.4 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.1 | 12.7 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.1 | 11.2 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
| 0.2 | 11.0 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 10.7 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.1 | 10.1 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.2 | 9.6 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 1.0 | 9.0 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.2 | 8.5 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 137.8 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 25.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.6 | 15.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 14.1 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 11.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 9.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 9.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.4 | 9.2 | GO:0031332 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.4 | 9.0 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.3 | 8.6 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.6 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 28.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 28.4 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 20.0 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 1.1 | 15.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 13.3 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 13.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.5 | 12.4 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.3 | 12.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.2 | 11.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 21.2 | PID EPO PATHWAY | EPO signaling pathway |
| 0.1 | 17.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 15.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 14.8 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 11.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 11.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 9.6 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 9.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 8.7 | PID P53 REGULATION PATHWAY | p53 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.9 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.1 | 14.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 14.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 12.8 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.1 | 12.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 12.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.2 | 9.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 9.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.2 | 8.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 8.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |