ISMARA results: ZIC3

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Illumina Body Map 2: averaged replicates

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Results for ZIC3_ZIC4

Z-value: 1.65

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol	Gene ID	Gene Info
ZIC3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000156925.7	Zic family member 3
ZIC4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000174963.13	Zic family member 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZIC4	hg19_v2_chr3_-_147123837_147123920	-0.19	3.1e-01	Click!
ZIC3	hg19_v2_chrX_+_136648643_136648711	-0.13	4.8e-01	Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_2182388 Show fit	4.31	ENST00000421783.1 ENST00000397262.1 ENST00000250971.3 ENST00000381330.4 ENST00000397270.1	INS Ensembl NCBI GeneCards UniProt NextProt Show fit INS-IGF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin INS-IGF2 readthrough
chr19_-_10024496 Show fit	2.61	ENST00000593091.1	OLFM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	olfactomedin 2
chr3_+_148847371 Show fit	2.46	ENST00000296051.2 ENST00000460120.1	HPS3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Hermansky-Pudlak syndrome 3
chr5_+_75699149 Show fit	2.42	ENST00000379730.3	IQGAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	IQ motif containing GTPase activating protein 2
chr2_+_234627424 Show fit	2.30	ENST00000373409.3	UGT1A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A4
chr3_+_184097836 Show fit	2.27	ENST00000204604.1 ENST00000310236.3	CHRD Ensembl NCBI GeneCards UniProt NextProt Show fit	chordin
chr10_-_48416849 Show fit	2.13	ENST00000249598.1	GDF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth differentiation factor 2
chr7_-_994302 Show fit	2.12	ENST00000265846.5	ADAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ArfGAP with dual PH domains 1
chr11_+_66790816 Show fit	2.10	ENST00000527043.1	SYT12 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin XII
chr17_+_79761997 Show fit	2.04	ENST00000400723.3 ENST00000570996.1	GCGR Ensembl NCBI GeneCards UniProt NextProt Show fit	glucagon receptor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	6.3	GO:0006789	bilirubin conjugation(GO:0006789)
0.2	4.4	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
1.4	4.3	GO:0033861	negative regulation of NAD(P)H oxidase activity(GO:0033861)
1.4	4.3	GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.1	4.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.1	3.9	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
1.2	3.5	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)
0.1	3.2	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	3.0	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.1	2.6	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)

Showing 1 to 10 of 209 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2	4.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	4.2	GO:0031941	filamentous actin(GO:0031941)
0.0	3.5	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	3.2	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	2.8	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	2.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.6	2.5	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	1.9	GO:0031526	brush border membrane(GO:0031526)
0.0	1.9	GO:1904724	tertiary granule lumen(GO:1904724)

Showing 1 to 10 of 77 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.1	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.3	4.4	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	4.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	4.0	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.4	3.5	GO:0016842	amidine-lyase activity(GO:0016842)
0.3	3.5	GO:0045545	syndecan binding(GO:0045545)
0.0	2.8	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.3	2.6	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1	2.3	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.4	2.2	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)

Showing 1 to 10 of 128 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.0	PID BMP PATHWAY	BMP receptor signaling
0.1	4.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	2.3	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	2.2	PID ARF6 PATHWAY	Arf6 signaling events
0.1	2.0	PID ALK1 PATHWAY	ALK1 signaling events
0.0	2.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.5	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	1.1	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.0	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.3	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	4.6	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.1	3.9	REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	Genes involved in Glucagon signaling in metabolic regulation
0.1	2.6	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	2.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	2.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	2.2	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	2.1	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.1	2.0	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	1.6	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols

Showing 1 to 10 of 48 entries

Results for ZIC3_ZIC4

Z-value: 1.65

Motif logo

Transcription factors associated with ZIC3_ZIC4

Activity-expression correlation:

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: