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Illumina Body Map 2: averaged replicates

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Results for ZKSCAN3

Z-value: 0.82

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_28317761-0.281.2e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_100867486 2.57 ENST00000548884.1
nuclear receptor subfamily 1, group H, member 4
chr12_+_100867694 2.36 ENST00000392986.3
ENST00000549996.1
nuclear receptor subfamily 1, group H, member 4
chr12_+_100867733 2.11 ENST00000546380.1
nuclear receptor subfamily 1, group H, member 4
chr19_+_39786962 1.28 ENST00000333625.2
interferon, lambda 1
chr18_-_74728998 1.20 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
myelin basic protein
chr2_-_61244550 1.02 ENST00000421319.1
pseudouridylate synthase 10
chr7_+_155089486 0.98 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
insulin induced gene 1
chr19_+_49258775 0.98 ENST00000593756.1
fibroblast growth factor 21
chr5_+_65018017 0.97 ENST00000380985.5
ENST00000502464.1
neurolysin (metallopeptidase M3 family)
chr21_+_39668831 0.96 ENST00000419868.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_156123359 0.93 ENST00000368284.1
ENST00000368286.2
ENST00000438830.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr21_+_39668478 0.90 ENST00000398927.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_156123318 0.88 ENST00000368285.3
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr1_+_226250379 0.85 ENST00000366815.3
ENST00000366814.3
H3 histone, family 3A
chr14_-_22103096 0.84 ENST00000542433.1
olfactory receptor, family 10, subfamily G, member 2
chr1_+_114473350 0.78 ENST00000503968.1
homeodomain interacting protein kinase 1
chr7_+_155090271 0.78 ENST00000476756.1
insulin induced gene 1
chr16_-_28506840 0.74 ENST00000569430.1
ceroid-lipofuscinosis, neuronal 3
chr1_+_114472992 0.65 ENST00000514621.1
homeodomain interacting protein kinase 1
chr9_+_127023704 0.65 ENST00000373596.1
ENST00000425237.1
NIMA-related kinase 6
chr2_-_61244308 0.63 ENST00000407787.1
ENST00000398658.2
pseudouridylate synthase 10
chr7_-_155089251 0.49 ENST00000609974.1
AC144652.1
chr1_-_19811132 0.48 ENST00000433834.1
capping protein (actin filament) muscle Z-line, beta
chr1_-_19811996 0.47 ENST00000264203.3
ENST00000401084.2
capping protein (actin filament) muscle Z-line, beta
chr6_-_35656712 0.45 ENST00000357266.4
ENST00000542713.1
FK506 binding protein 5
chr11_-_64013663 0.43 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr16_-_745946 0.42 ENST00000562563.1
F-box and leucine-rich repeat protein 16
chr1_+_66258846 0.41 ENST00000341517.4
phosphodiesterase 4B, cAMP-specific
chr1_-_19811962 0.36 ENST00000375142.1
ENST00000264202.6
capping protein (actin filament) muscle Z-line, beta
chr16_-_4039001 0.36 ENST00000576936.1
adenylate cyclase 9
chr14_+_94492674 0.33 ENST00000203664.5
ENST00000553723.1
OTU domain, ubiquitin aldehyde binding 2
chr17_+_36908984 0.32 ENST00000225426.4
ENST00000579088.1
proteasome (prosome, macropain) subunit, beta type, 3
chr8_+_123793633 0.32 ENST00000314393.4
zinc fingers and homeoboxes 2
chr22_+_50312379 0.32 ENST00000407217.3
ENST00000403427.3
cysteine-rich with EGF-like domains 2
chr11_-_64013288 0.31 ENST00000542235.1
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr22_+_50312274 0.30 ENST00000404488.3
cysteine-rich with EGF-like domains 2
chr11_-_67272794 0.30 ENST00000436757.2
ENST00000356404.3
phosphatidylinositol transfer protein, membrane-associated 1
chr22_+_50312316 0.29 ENST00000328268.4
cysteine-rich with EGF-like domains 2
chr16_-_832054 0.28 ENST00000543963.1
mesothelin-like
chr1_-_28415204 0.28 ENST00000373871.3
eyes absent homolog 3 (Drosophila)
chr17_-_62499334 0.27 ENST00000579996.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr15_+_74610894 0.27 ENST00000558821.1
ENST00000268082.4
coiled-coil domain containing 33
chr1_-_28415075 0.27 ENST00000373863.3
ENST00000436342.2
ENST00000540618.1
ENST00000545175.1
eyes absent homolog 3 (Drosophila)
chr5_-_65017921 0.26 ENST00000381007.4
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr16_-_832926 0.24 ENST00000293892.3
mesothelin-like
chr17_-_60142609 0.23 ENST00000397786.2
mediator complex subunit 13
chr6_+_116850174 0.23 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
family with sequence similarity 26, member D
chr6_+_32936353 0.20 ENST00000374825.4
bromodomain containing 2
chr3_+_50316458 0.19 ENST00000316436.3
leucine-rich single-pass membrane protein 2
chr15_+_41624892 0.18 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
nucleolar and spindle associated protein 1
chr10_+_21823079 0.18 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr19_-_4182530 0.18 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
sirtuin 6
chrX_+_153775869 0.16 ENST00000424839.1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr11_-_111320706 0.16 ENST00000531398.1
POU class 2 associating factor 1
chrX_+_153775821 0.15 ENST00000263518.6
ENST00000470142.1
ENST00000393549.2
ENST00000455588.2
ENST00000369602.3
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr7_+_150782945 0.15 ENST00000463381.1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr12_+_113796347 0.15 ENST00000545182.2
ENST00000280800.3
phospholipase B domain containing 2
chr19_-_4182497 0.14 ENST00000597896.1
sirtuin 6
chr12_-_3982511 0.12 ENST00000427057.2
ENST00000228820.4
poly (ADP-ribose) polymerase family, member 11
chr3_-_122512619 0.12 ENST00000383659.1
ENST00000306103.2
HSPB (heat shock 27kDa) associated protein 1
chr5_-_114598548 0.12 ENST00000379615.3
ENST00000419445.1
protein geranylgeranyltransferase type I, beta subunit
chr12_-_113573495 0.11 ENST00000446861.3
RAS protein activator like 1 (GAP1 like)
chr5_-_180235755 0.11 ENST00000502678.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr6_-_31508304 0.10 ENST00000376177.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr22_-_50312052 0.10 ENST00000330817.6
ALG12, alpha-1,6-mannosyltransferase
chr19_+_54372639 0.10 ENST00000391769.2
myeloid-associated differentiation marker
chr15_-_41624685 0.09 ENST00000560640.1
ENST00000220514.3
Opa interacting protein 5
chr10_+_21823243 0.08 ENST00000307729.7
ENST00000377091.2
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chrX_+_85403445 0.08 ENST00000373131.1
dachshund homolog 2 (Drosophila)
chr12_+_109535923 0.07 ENST00000336865.2
uracil-DNA glycosylase
chr5_+_140079919 0.06 ENST00000274712.3
zinc finger, matrin-type 2
chrX_+_85403487 0.06 ENST00000373125.4
dachshund homolog 2 (Drosophila)
chr12_-_3982548 0.06 ENST00000397096.2
ENST00000447133.3
ENST00000450737.2
poly (ADP-ribose) polymerase family, member 11
chr19_-_39735646 0.05 ENST00000413851.2
interferon, lambda 3
chr1_-_99470368 0.05 ENST00000263177.4
Lipid phosphate phosphatase-related protein type 5
chr1_-_115259337 0.04 ENST00000369535.4
neuroblastoma RAS viral (v-ras) oncogene homolog
chrX_-_153775760 0.03 ENST00000440967.1
ENST00000393564.2
ENST00000369620.2
glucose-6-phosphate dehydrogenase
chr1_-_99470558 0.03 ENST00000370188.3
Lipid phosphate phosphatase-related protein type 5
chr2_+_191221240 0.01 ENST00000409027.1
ENST00000458193.1
inositol polyphosphate-1-phosphatase

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:0072615 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.6 1.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 1.0 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.2 1.3 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.2 0.8 GO:0060623 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.2 1.2 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.2 1.0 GO:1904640 response to methionine(GO:1904640)
0.2 0.7 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 1.6 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.1 1.4 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.3 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.0 1.8 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.4 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.6 GO:2000772 regulation of cellular senescence(GO:2000772)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 1.3 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.2 1.3 GO:0071203 WASH complex(GO:0071203)
0.1 7.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.8 GO:0001740 Barr body(GO:0001740)
0.1 1.2 GO:0033269 internode region of axon(GO:0033269)
0.1 0.3 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.1 0.3 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.1 1.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.7 GO:0019888 protein phosphatase inhibitor activity(GO:0004864) phosphatase regulator activity(GO:0019208) phosphatase inhibitor activity(GO:0019212) protein phosphatase regulator activity(GO:0019888)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 1.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.3 GO:0035500 MH2 domain binding(GO:0035500)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening