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Illumina Body Map 2: averaged replicates
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Results for ZNF652
Z-value: 2.10
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Transcription factors associated with ZNF652
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF652 | hg19_v2_chr17_-_47439437_47439533 | 0.13 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_90757364 Show fit | 5.22 |
ENST00000508895.1
|
synuclein, alpha (non A4 component of amyloid precursor) |
|
| chr4_-_90756769 Show fit | 4.35 |
ENST00000345009.4
ENST00000505199.1 ENST00000502987.1 |
synuclein, alpha (non A4 component of amyloid precursor) |
|
| chrX_+_103031758 Show fit | 4.24 |
ENST00000303958.2
ENST00000361621.2 |
proteolipid protein 1 |
|
| chr17_-_10741762 Show fit | 3.76 |
ENST00000580256.2
|
phosphoinositide-interacting regulator of transient receptor potential channels |
|
| chr2_-_220174166 Show fit | 3.71 |
ENST00000409251.3
ENST00000451506.1 ENST00000295718.2 ENST00000446182.1 |
protein tyrosine phosphatase, receptor type, N |
|
| chr11_-_130298888 Show fit | 3.63 |
ENST00000257359.6
|
ADAM metallopeptidase with thrombospondin type 1 motif, 8 |
|
| chr6_-_34524049 Show fit | 3.34 |
ENST00000374037.3
|
SAM pointed domain containing ETS transcription factor |
|
| chr6_-_34524093 Show fit | 3.15 |
ENST00000544425.1
|
SAM pointed domain containing ETS transcription factor |
|
| chr9_+_74764340 Show fit | 3.12 |
ENST00000376986.1
ENST00000358399.3 |
guanine deaminase |
|
| chr16_+_56623433 Show fit | 3.11 |
ENST00000570176.1
|
metallothionein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF652
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.0 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 1.9 | 9.6 | GO:0051585 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 6.9 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.9 | 6.5 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
| 1.8 | 5.5 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.0 | 4.6 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.2 | 4.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 4.3 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.2 | 4.2 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.2 | 4.1 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.2 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 10.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 9.6 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 7.1 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 6.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.3 | 6.0 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 5.7 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 4.9 | GO:0034705 | potassium channel complex(GO:0034705) |
| 0.1 | 4.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 4.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 9.6 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.5 | 6.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 6.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.4 | 6.0 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.3 | 6.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 6.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 1.8 | 5.5 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.3 | 4.4 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.0 | 4.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.3 | 3.9 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 11.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 6.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 3.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 3.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 5.5 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 4.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 4.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 3.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 3.6 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 3.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 2.8 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 2.8 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |