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Illumina Body Map 2: averaged replicates
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Results for ZNF711_TFAP2A_TFAP2D
Z-value: 4.71
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Transcription factors associated with ZNF711_TFAP2A_TFAP2D
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000147180.12 | zinc finger protein 711 | |
| ENSG00000137203.6 | transcription factor AP-2 alpha | |
| ENSG00000008197.4 | transcription factor AP-2 delta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF711 | hg19_v2_chrX_+_84499081_84499115 | -0.70 | 9.7e-06 | Click! |
| TFAP2D | hg19_v2_chr6_+_50681541_50681541 | -0.55 | 1.2e-03 | Click! |
| TFAP2A | hg19_v2_chr6_-_10415470_10415508 | -0.31 | 8.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF711_TFAP2A_TFAP2D
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 112.9 | GO:0006415 | translational termination(GO:0006415) |
| 1.4 | 89.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 1.0 | 80.2 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.7 | 64.1 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.7 | 62.9 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.5 | 57.2 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.5 | 56.8 | GO:1902750 | negative regulation of cell cycle G2/M phase transition(GO:1902750) |
| 0.4 | 52.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.4 | 49.7 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.7 | 48.2 | GO:0035329 | hippo signaling(GO:0035329) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 567.3 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.7 | 336.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 313.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.7 | 142.7 | GO:0031674 | I band(GO:0031674) |
| 0.1 | 116.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.4 | 107.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 3.8 | 91.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.3 | 87.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.4 | 73.0 | GO:0016605 | PML body(GO:0016605) |
| 1.1 | 71.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 283.4 | GO:0003723 | RNA binding(GO:0003723) |
| 0.6 | 165.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.8 | 98.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 80.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 75.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 4.0 | 56.6 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.7 | 54.3 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 53.2 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 51.4 | GO:0003676 | nucleic acid binding(GO:0003676) |
| 0.7 | 48.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 79.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 71.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 59.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.4 | 59.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 58.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.9 | 58.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.7 | 53.8 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.2 | 53.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 42.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.7 | 38.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 118.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.6 | 106.6 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.3 | 86.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.8 | 72.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 70.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.6 | 69.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.9 | 61.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.0 | 53.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.6 | 52.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.9 | 51.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |