ISMARA results: AAUACUG

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Illumina Body Map 2

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Results for AAUACUG

Z-value: 0.85

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miRNA associated with seed AAUACUG

Name	miRBASE accession
hsa-miR-200b-3p miRBase	MIMAT0000318
hsa-miR-200c-3p miRBase	MIMAT0000617
hsa-miR-429 miRBase	MIMAT0001536

Activity profile of AAUACUG motif

Sorted Z-values of AAUACUG motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_151344172 Show fit	1.85	ENST00000375734.2 ENST00000263895.4 ENST00000454202.1	RND3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho family GTPase 3
chr1_+_77333117 Show fit	1.81	ENST00000477717.1	ST6GALNAC5 Ensembl NCBI GeneCards UniProt NextProt Show fit	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr16_+_86544113 Show fit	1.68	ENST00000262426.4	FOXF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	forkhead box F1
chr4_+_20255123 Show fit	1.59	ENST00000504154.1 ENST00000273739.5	SLIT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	slit homolog 2 (Drosophila)
chr11_-_46940074 Show fit	1.57	ENST00000378623.1 ENST00000534404.1	LRP4 Ensembl NCBI GeneCards UniProt NextProt Show fit	low density lipoprotein receptor-related protein 4
chr13_-_107187462 Show fit	1.51	ENST00000245323.4	EFNB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ephrin-B2
chr10_+_102106829 Show fit	1.50	ENST00000370355.2	SCD Ensembl NCBI GeneCards UniProt NextProt Show fit	stearoyl-CoA desaturase (delta-9-desaturase)
chrX_-_6146876 Show fit	1.49	ENST00000381095.3	NLGN4X Ensembl NCBI GeneCards UniProt NextProt Show fit	neuroligin 4, X-linked
chr1_+_201252580 Show fit	1.47	ENST00000367324.3 ENST00000263946.3	PKP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
chr19_+_15218180 Show fit	1.42	ENST00000342784.2 ENST00000597977.1 ENST00000600440.1	SYDE1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUACUG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.5	GO:0003360	brainstem development(GO:0003360)
0.1	2.2	GO:0070831	basement membrane assembly(GO:0070831)
0.1	2.0	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.0	2.0	GO:0035329	hippo signaling(GO:0035329)
0.2	1.9	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.6	1.7	GO:0048611	ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) right lung development(GO:0060458)
0.5	1.6	GO:0090024	negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.5	1.6	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1	1.6	GO:0097490	sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.5	1.5	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)

Showing 1 to 10 of 179 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	2.2	GO:0005796	Golgi lumen(GO:0005796)
0.2	1.6	GO:0002116	semaphorin receptor complex(GO:0002116)
0.1	1.5	GO:0045180	basal cortex(GO:0045180)
0.0	1.5	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	1.4	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	1.4	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	1.3	GO:0097443	sorting endosome(GO:0097443)
0.0	1.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.2	1.1	GO:0071148	TEAD-1-YAP complex(GO:0071148)

Showing 1 to 10 of 65 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	2.3	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	2.1	GO:0005262	calcium channel activity(GO:0005262)
0.0	1.9	GO:0046875	ephrin receptor binding(GO:0046875)
0.2	1.8	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2	1.6	GO:0043237	laminin-1 binding(GO:0043237)
0.1	1.6	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	1.6	GO:0008013	beta-catenin binding(GO:0008013)
0.2	1.5	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1	1.5	GO:0030280	structural constituent of epidermis(GO:0030280)

Showing 1 to 10 of 109 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	2.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	2.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	1.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	1.2	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.1	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.9	PID HIF2PATHWAY	HIF-2-alpha transcription factor network

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	2.9	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	2.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.7	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	1.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	1.5	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.1	1.4	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	1.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	1.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	1.2	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters

Showing 1 to 10 of 28 entries

Results for AAUACUG

Z-value: 0.85

Motif logo

miRNA associated with seed AAUACUG

Activity profile of AAUACUG motif

Sorted Z-values of AAUACUG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUACUG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: