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Illumina Body Map 2

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Results for AAUCUCA

Z-value: 0.32

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miRNA associated with seed AAUCUCA

NamemiRBASE accession
hsa-miR-216a-5p
MIMAT0000273

Activity profile of AAUCUCA motif

Sorted Z-values of AAUCUCA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_50344516 2.26 ENST00000199280.3
ENST00000550862.1
AQP2
aquaporin 2 (collecting duct)
chr11_-_32452357 0.83 ENST00000379079.2
ENST00000530998.1
WT1
Wilms tumor 1
chr5_+_122424816 0.45 ENST00000407847.4
PRDM6
PR domain containing 6
chr1_+_63788730 0.39 ENST00000371116.2
FOXD3
forkhead box D3
chr1_-_67519782 0.30 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr5_-_178054105 0.25 ENST00000316308.4
CLK4
CDC-like kinase 4
chr9_-_20622478 0.24 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_+_99916765 0.24 ENST00000296411.6
METAP1
methionyl aminopeptidase 1
chr14_+_62037287 0.22 ENST00000556569.1
RP11-47I22.3
Uncharacterized protein
chr15_+_40733387 0.17 ENST00000416165.1
BAHD1
bromo adjacent homology domain containing 1
chr12_-_57030115 0.14 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr1_-_53793584 0.14 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr7_-_139876812 0.13 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr17_+_14204389 0.11 ENST00000360954.2
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chrX_-_20284958 0.11 ENST00000379565.3
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr2_-_242212227 0.09 ENST00000427007.1
ENST00000458564.1
ENST00000452065.1
ENST00000427183.2
ENST00000426343.1
ENST00000422080.1
ENST00000449504.1
ENST00000449864.1
ENST00000391975.1
HDLBP
high density lipoprotein binding protein
chr18_+_59854480 0.09 ENST00000256858.6
ENST00000398130.2
KIAA1468
KIAA1468
chr4_-_113437328 0.08 ENST00000313341.3
NEUROG2
neurogenin 2
chr6_+_42749759 0.08 ENST00000314073.5
GLTSCR1L
GLTSCR1-like
chrX_+_23352133 0.08 ENST00000379361.4
PTCHD1
patched domain containing 1
chr17_+_64298944 0.07 ENST00000413366.3
PRKCA
protein kinase C, alpha
chr13_-_31038370 0.07 ENST00000399489.1
ENST00000339872.4
HMGB1
high mobility group box 1
chr1_-_67896095 0.05 ENST00000370994.4
SERBP1
SERPINE1 mRNA binding protein 1
chr13_-_45915221 0.05 ENST00000309246.5
ENST00000379060.4
ENST00000379055.1
ENST00000527226.1
ENST00000379056.1
TPT1
tumor protein, translationally-controlled 1
chr18_+_59992527 0.04 ENST00000586569.1
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr20_-_524455 0.02 ENST00000349736.5
ENST00000217244.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUCUCA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0071288 cellular response to mercury ion(GO:0071288)
0.2 0.8 GO:0072302 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.0 0.3 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.4 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.1 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0071848 circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.2 0.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.1 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins