ISMARA results: AIRE

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Illumina Body Map 2

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Results for AIRE

Z-value: 0.95

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Transcription factors associated with AIRE

Gene Symbol	Gene ID	Gene Info
AIRE Ensembl NCBI GeneCards UniProt NextProt	ENSG00000160224.12	autoimmune regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
AIRE	hg19_v2_chr21_+_45705752_45705767	0.08	6.6e-01	Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_106668095 Show fit	3.71	ENST00000390606.2	IGHV3-20 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 3-20
chr14_-_106967788 Show fit	3.66	ENST00000390622.2	IGHV1-46 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-46
chr7_-_142181009 Show fit	3.18	ENST00000390368.2	TRBV6-5 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta variable 6-5
chr9_-_104198042 Show fit	3.17	ENST00000374855.4	ALDOB Ensembl NCBI GeneCards UniProt NextProt Show fit	aldolase B, fructose-bisphosphate
chr16_+_32077386 Show fit	2.99	ENST00000354689.6	IGHV3OR16-9 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr17_-_38721711 Show fit	2.56	ENST00000578085.1 ENST00000246657.2	CCR7 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) receptor 7
chr7_-_142162390 Show fit	2.39	ENST00000390371.3	TRBV6-6 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta variable 6-6
chr3_+_46412345 Show fit	2.38	ENST00000292303.4	CCR5 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr15_-_22448819 Show fit	2.31	ENST00000604066.1	IGHV1OR15-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr2_-_89568263 Show fit	2.21	ENST00000473726.1	IGKV1-33 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-33

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.0	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	5.9	GO:0006958	complement activation, classical pathway(GO:0006958)
0.2	3.9	GO:0010764	negative regulation of fibroblast migration(GO:0010764)
0.0	3.6	GO:0031295	T cell costimulation(GO:0031295)
0.5	3.2	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.9	2.6	GO:2000523	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.8	2.5	GO:0030451	regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.6	2.4	GO:0010900	negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.3	2.4	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0	2.3	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)

Showing 1 to 10 of 66 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	6.1	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	5.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	3.3	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	3.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	2.5	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	2.4	GO:0042627	chylomicron(GO:0042627)
0.0	2.1	GO:0072562	blood microparticle(GO:0072562)
0.1	1.9	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.0	1.6	GO:1904724	tertiary granule lumen(GO:1904724)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	7.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
1.5	6.0	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
0.0	6.0	GO:0003823	antigen binding(GO:0003823)
0.3	5.9	GO:0019957	C-C chemokine binding(GO:0019957)
0.3	3.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	2.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.8	2.5	GO:0001861	complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.2	2.4	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0	2.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)

Showing 1 to 10 of 50 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	3.6	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	3.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	2.6	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	2.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.5	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	1.4	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	1.3	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.1	3.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	3.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	3.2	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	2.7	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	2.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.4	2.4	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	2.1	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	1.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.7	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins

Showing 1 to 10 of 20 entries

Results for AIRE

Z-value: 0.95

Motif logo

Transcription factors associated with AIRE

Activity-expression correlation:

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: