Project

Illumina Body Map 2

Navigation
Downloads

Results for AIRE

Z-value: 0.95

Motif logo

logo of

Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.12 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.086.6e-01Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_106668095 3.71 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr14_-_106967788 3.66 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr7_-_142181009 3.18 ENST00000390368.2
TRBV6-5
T cell receptor beta variable 6-5
chr9_-_104198042 3.17 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr16_+_32077386 2.99 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr17_-_38721711 2.56 ENST00000578085.1
ENST00000246657.2
CCR7
chemokine (C-C motif) receptor 7
chr7_-_142162390 2.39 ENST00000390371.3
TRBV6-6
T cell receptor beta variable 6-6
chr3_+_46412345 2.38 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr15_-_22448819 2.31 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr2_-_89568263 2.21 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr7_-_36764142 2.13 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr7_-_36764004 2.10 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr7_+_150498783 2.02 ENST00000475536.1
ENST00000468689.1
TMEM176A
transmembrane protein 176A
chr22_+_40322595 1.98 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr14_-_107283278 1.79 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr7_-_36764062 1.75 ENST00000435386.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr12_+_75874984 1.75 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr22_+_40322623 1.65 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr20_+_44637526 1.63 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr6_-_149806105 1.59 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
ZC3H12D
zinc finger CCCH-type containing 12D
chr12_+_75874580 1.58 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr1_+_40840320 1.56 ENST00000372708.1
SMAP2
small ArfGAP2
chr4_+_156775910 1.55 ENST00000506072.1
ENST00000507590.1
TDO2
tryptophan 2,3-dioxygenase
chr5_+_118691008 1.52 ENST00000504642.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr16_+_72088376 1.52 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chrX_-_153191708 1.40 ENST00000393721.1
ENST00000370028.3
ARHGAP4
Rho GTPase activating protein 4
chrX_-_153191674 1.36 ENST00000350060.5
ENST00000370016.1
ARHGAP4
Rho GTPase activating protein 4
chr2_+_204732487 1.33 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr1_+_207669573 1.28 ENST00000400960.2
ENST00000534202.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr1_+_207669613 1.22 ENST00000367049.4
ENST00000529814.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr2_-_225811747 1.19 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr8_+_24241789 1.17 ENST00000256412.4
ENST00000538205.1
ADAMDEC1
ADAM-like, decysin 1
chrX_-_153192211 1.14 ENST00000461052.1
ENST00000422091.1
ARHGAP4
Rho GTPase activating protein 4
chr1_-_161208013 1.09 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr19_+_18208603 1.08 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr12_+_75874460 1.04 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr15_-_52043722 1.00 ENST00000454181.2
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr14_-_75330537 0.99 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2
prospero homeobox 2
chr13_-_46756351 0.97 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_45417812 0.94 ENST00000592535.1
APOC1
apolipoprotein C-I
chr12_+_7282795 0.94 ENST00000266546.6
CLSTN3
calsyntenin 3
chr6_+_167525277 0.94 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr1_+_47603109 0.92 ENST00000371890.3
ENST00000294337.3
ENST00000371891.3
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr7_-_55606346 0.90 ENST00000545390.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr5_+_118690466 0.88 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr15_-_52043631 0.85 ENST00000558126.1
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr19_-_23869999 0.82 ENST00000601935.1
ENST00000359788.4
ENST00000600313.1
ENST00000596211.1
ENST00000599168.1
ZNF675
zinc finger protein 675
chr19_+_45417921 0.77 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr10_-_101841588 0.74 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr19_+_45418067 0.71 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr15_-_81202118 0.70 ENST00000560560.1
RP11-351M8.1
Uncharacterized protein
chr1_-_154600421 0.70 ENST00000368471.3
ENST00000292205.5
ADAR
adenosine deaminase, RNA-specific
chr1_-_161207986 0.69 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr16_+_11439286 0.69 ENST00000312499.5
ENST00000576027.1
RMI2
RecQ mediated genome instability 2
chr8_+_124780672 0.69 ENST00000521166.1
ENST00000334705.7
FAM91A1
family with sequence similarity 91, member A1
chr16_+_50914085 0.69 ENST00000576842.1
CTD-2034I21.2
CTD-2034I21.2
chr7_-_86849836 0.68 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr1_+_96208646 0.66 ENST00000603401.1
RP11-286B14.2
RP11-286B14.2
chr11_+_94038759 0.64 ENST00000440961.2
ENST00000328458.4
FOLR4
folate receptor 4, delta (putative)
chr12_-_6579833 0.62 ENST00000396308.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr21_+_39644305 0.61 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr16_+_56672571 0.61 ENST00000290705.8
MT1A
metallothionein 1A
chr3_+_193965426 0.60 ENST00000455821.1
RP11-513G11.3
RP11-513G11.3
chr2_+_62423242 0.60 ENST00000301998.4
B3GNT2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr12_-_6579808 0.60 ENST00000535180.1
ENST00000400911.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr14_-_65409438 0.60 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr21_+_39644172 0.59 ENST00000398932.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr9_+_90112117 0.56 ENST00000358077.5
DAPK1
death-associated protein kinase 1
chr19_-_48753104 0.56 ENST00000447740.2
CARD8
caspase recruitment domain family, member 8
chr4_-_120222076 0.56 ENST00000504110.1
C4orf3
chromosome 4 open reading frame 3
chr16_-_89119355 0.55 ENST00000537498.1
CTD-2555A7.2
CTD-2555A7.2
chr15_+_52043813 0.55 ENST00000435126.2
TMOD2
tropomodulin 2 (neuronal)
chr10_-_106240032 0.54 ENST00000447860.1
RP11-127O4.3
RP11-127O4.3
chr21_+_39644214 0.53 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr18_-_56985776 0.53 ENST00000587244.1
CPLX4
complexin 4
chr13_-_26795840 0.52 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
RNF6
ring finger protein (C3H2C3 type) 6
chr19_-_48752812 0.51 ENST00000359009.4
CARD8
caspase recruitment domain family, member 8
chr12_-_6580094 0.49 ENST00000361716.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr4_+_69917078 0.49 ENST00000502942.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr12_+_20963647 0.49 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr7_-_87936195 0.47 ENST00000414498.1
ENST00000301959.5
ENST00000380079.4
STEAP4
STEAP family member 4
chrY_-_21738068 0.47 ENST00000599485.1
AC009977.1
Uncharacterized protein
chr19_-_23869970 0.46 ENST00000601010.1
ZNF675
zinc finger protein 675
chr16_-_20566616 0.45 ENST00000569163.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr15_+_85523671 0.45 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr10_+_90660832 0.44 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr19_-_48753064 0.44 ENST00000520153.1
ENST00000357778.5
ENST00000520015.1
CARD8
caspase recruitment domain family, member 8
chr20_-_33735070 0.43 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr19_-_48753028 0.42 ENST00000522431.1
CARD8
caspase recruitment domain family, member 8
chr4_-_120243545 0.42 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr15_+_52043758 0.41 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr11_-_327537 0.40 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr6_-_127663543 0.40 ENST00000531582.1
ECHDC1
enoyl CoA hydratase domain containing 1
chr3_-_49466686 0.39 ENST00000273598.3
ENST00000436744.2
NICN1
nicolin 1
chr13_-_30160925 0.39 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr15_-_38519066 0.38 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr11_+_6947647 0.38 ENST00000278319.5
ZNF215
zinc finger protein 215
chr19_-_36304201 0.37 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr10_-_46030841 0.37 ENST00000453424.2
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr6_+_26104104 0.37 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr21_+_39644395 0.36 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr5_-_36242119 0.35 ENST00000511088.1
ENST00000282512.3
ENST00000506945.1
NADK2
NAD kinase 2, mitochondrial
chr8_+_105352050 0.35 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr19_-_21950362 0.34 ENST00000358296.6
ZNF100
zinc finger protein 100
chr1_+_174670143 0.34 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr16_+_75182376 0.33 ENST00000570010.1
ENST00000568079.1
ENST00000464850.1
ENST00000332307.4
ENST00000393430.2
ZFP1
ZFP1 zinc finger protein
chr17_-_70989072 0.32 ENST00000582769.1
SLC39A11
solute carrier family 39, member 11
chr17_-_295730 0.32 ENST00000329099.4
FAM101B
family with sequence similarity 101, member B
chr9_-_4666421 0.32 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr8_-_16043780 0.32 ENST00000445506.2
MSR1
macrophage scavenger receptor 1
chr16_+_50059125 0.31 ENST00000427478.2
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr7_-_64467031 0.31 ENST00000394323.2
ERV3-1
endogenous retrovirus group 3, member 1
chr5_+_72143988 0.31 ENST00000506351.2
TNPO1
transportin 1
chr1_+_36038971 0.30 ENST00000373235.3
TFAP2E
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr1_+_79115503 0.30 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr18_-_56985873 0.29 ENST00000299721.3
CPLX4
complexin 4
chr8_+_86851932 0.29 ENST00000517368.1
CTA-392E5.1
CTA-392E5.1
chr8_+_54764346 0.29 ENST00000297313.3
ENST00000344277.6
RGS20
regulator of G-protein signaling 20
chr14_-_46185155 0.29 ENST00000555442.1
RP11-369C8.1
RP11-369C8.1
chr4_-_47465666 0.29 ENST00000381571.4
COMMD8
COMM domain containing 8
chr12_-_113772835 0.29 ENST00000552014.1
ENST00000548186.1
ENST00000202831.3
ENST00000549181.1
SLC8B1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr14_-_55658252 0.28 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr19_-_4902877 0.28 ENST00000381781.2
ARRDC5
arrestin domain containing 5
chr16_+_50059182 0.28 ENST00000562576.1
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chrX_+_70503526 0.27 ENST00000413858.1
ENST00000450092.1
NONO
non-POU domain containing, octamer-binding
chr8_+_128748308 0.26 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr4_-_104119528 0.26 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chrX_-_100307043 0.26 ENST00000372939.1
ENST00000372935.1
ENST00000372936.3
TRMT2B
tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr2_-_104496621 0.25 ENST00000455716.1
AC013727.1
AC013727.1
chr7_+_80255472 0.25 ENST00000428497.1
CD36
CD36 molecule (thrombospondin receptor)
chr7_-_64023441 0.25 ENST00000309683.6
ZNF680
zinc finger protein 680
chr11_+_327171 0.24 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12
RP11-326C3.12
chr16_-_29499154 0.24 ENST00000354563.5
RP11-231C14.4
Uncharacterized protein
chr21_+_30502806 0.24 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr14_-_24911971 0.23 ENST00000555365.1
ENST00000399395.3
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr10_-_4720333 0.23 ENST00000430998.2
LINC00704
long intergenic non-protein coding RNA 704
chr14_-_24912047 0.23 ENST00000553930.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr11_-_85376121 0.23 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr14_-_55658323 0.22 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr12_-_11287243 0.22 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr9_-_114361919 0.22 ENST00000422125.1
PTGR1
prostaglandin reductase 1
chr6_-_32806506 0.22 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chrX_-_100307076 0.22 ENST00000338687.7
ENST00000545398.1
ENST00000372931.5
TRMT2B
tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr13_+_103459704 0.22 ENST00000602836.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr9_-_113761720 0.21 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr10_-_46030787 0.20 ENST00000395769.2
MARCH8
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chrM_+_5824 0.20 ENST00000361624.2
MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr19_+_56280507 0.20 ENST00000341750.4
RFPL4AL1
ret finger protein-like 4A-like 1
chr2_+_172864490 0.18 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chrM_+_12331 0.18 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr17_+_3323862 0.17 ENST00000291231.1
OR3A3
olfactory receptor, family 3, subfamily A, member 3
chr1_-_158300747 0.17 ENST00000451207.1
CD1B
CD1b molecule
chr19_-_10491234 0.17 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr4_-_17513851 0.17 ENST00000281243.5
QDPR
quinoid dihydropteridine reductase
chr3_+_107318157 0.16 ENST00000406780.1
BBX
bobby sox homolog (Drosophila)
chr21_-_44495964 0.15 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr3_-_121264848 0.15 ENST00000264233.5
POLQ
polymerase (DNA directed), theta
chr6_+_26538566 0.15 ENST00000377575.2
HMGN4
high mobility group nucleosomal binding domain 4
chr9_+_71357171 0.15 ENST00000440050.1
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr2_-_127977654 0.15 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr20_+_58203664 0.15 ENST00000541461.1
PHACTR3
phosphatase and actin regulator 3
chr19_-_59084922 0.14 ENST00000215057.2
ENST00000599369.1
MZF1
myeloid zinc finger 1
chr7_-_15601595 0.14 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr16_-_28503327 0.13 ENST00000535392.1
ENST00000395653.4
CLN3
ceroid-lipofuscinosis, neuronal 3
chr5_+_122181279 0.13 ENST00000395451.4
ENST00000506996.1
SNX24
sorting nexin 24
chr19_+_11455900 0.12 ENST00000588790.1
CCDC159
coiled-coil domain containing 159
chr1_-_52456352 0.12 ENST00000371655.3
RAB3B
RAB3B, member RAS oncogene family
chr12_+_20848486 0.12 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr12_-_50677255 0.11 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr18_+_39766626 0.11 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr5_+_122181184 0.10 ENST00000513881.1
SNX24
sorting nexin 24
chr2_+_38177575 0.10 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chrM_+_7586 0.10 ENST00000361739.1
MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr6_-_106773610 0.10 ENST00000369076.3
ENST00000369070.1
ATG5
autophagy related 5
chr3_-_133648656 0.10 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr1_-_35497506 0.09 ENST00000317538.5
ENST00000373340.2
ENST00000357182.4
ZMYM6
zinc finger, MYM-type 6
chr10_-_75682535 0.09 ENST00000409178.1
C10orf55
chromosome 10 open reading frame 55
chr2_-_166060571 0.09 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr7_-_149194843 0.09 ENST00000458143.2
ENST00000340622.3
ZNF746
zinc finger protein 746
chr21_-_44495919 0.08 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr16_+_57126428 0.08 ENST00000290776.8
CPNE2
copine II
chr9_-_70429731 0.08 ENST00000377413.1
FOXD4L4
forkhead box D4-like 4
chrX_+_70503433 0.07 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr19_-_10491130 0.07 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chr16_+_57126482 0.07 ENST00000537605.1
ENST00000535318.2
CPNE2
copine II
chr4_+_1385340 0.06 ENST00000324803.4
CRIPAK
cysteine-rich PAK1 inhibitor
chr5_+_122181128 0.06 ENST00000261369.4
SNX24
sorting nexin 24
chr15_+_27112948 0.06 ENST00000555060.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr8_-_141728444 0.06 ENST00000521562.1
PTK2
protein tyrosine kinase 2
chr3_-_176914191 0.06 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr20_+_12989596 0.06 ENST00000434210.1
ENST00000399002.2
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr1_+_100810575 0.05 ENST00000542213.1
CDC14A
cell division cycle 14A
chr9_-_114361665 0.05 ENST00000309195.5
PTGR1
prostaglandin reductase 1
chr2_-_166060552 0.05 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr4_+_78829479 0.05 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr7_+_76101379 0.05 ENST00000429179.1
DTX2
deltex homolog 2 (Drosophila)
chr12_-_11139511 0.05 ENST00000506868.1
TAS2R50
taste receptor, type 2, member 50
chr17_-_39334460 0.04 ENST00000377726.2
KRTAP4-2
keratin associated protein 4-2
chr7_+_116451100 0.03 ENST00000464223.1
ENST00000484325.1
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr15_-_83209210 0.03 ENST00000561157.1
ENST00000330244.6
RPS17L
ribosomal protein S17-like

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.8 2.5 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.6 2.4 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.5 3.2 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.5 1.5 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.4 1.3 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.4 1.5 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.3 2.4 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.2 0.7 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.2 3.9 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.2 0.9 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.2 0.3 GO:0034238 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.2 1.0 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.2 1.6 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.7 GO:0030070 insulin processing(GO:0030070)
0.1 1.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 2.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 11.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.5 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 0.9 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.6 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.8 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.9 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 1.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.4 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.2 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 1.6 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.9 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.1 1.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.3 GO:0090095 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.1 1.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.2 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.1 0.5 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 5.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.3 GO:0097327 response to antineoplastic agent(GO:0097327)
0.0 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.4 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.2 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.2 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 1.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 2.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.6 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 3.6 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.6 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.6 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 0.4 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.7 GO:0000732 strand displacement(GO:0000732)
0.0 0.2 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 1.8 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 2.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 10.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.9 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 0.6 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 2.4 GO:0042627 chylomicron(GO:0042627)
0.1 3.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.3 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.1 6.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 1.0 GO:0001891 phagocytic cup(GO:0001891)
0.0 2.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.3 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.3 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 5.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.0 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.8 2.5 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.3 5.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 1.9 GO:0032089 NACHT domain binding(GO:0032089)
0.3 1.8 GO:0004882 androgen receptor activity(GO:0004882)
0.3 3.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.5 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.3 1.5 GO:0030492 hemoglobin binding(GO:0030492)
0.2 2.4 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 10.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.7 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.6 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 0.4 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.3 GO:0032440 2-alkenal reductase [NAD(P)] activity(GO:0032440)
0.1 0.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 2.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.9 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.1 0.5 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.2 GO:0070025 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.1 0.2 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.1 0.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 7.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 2.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.1 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.5 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0005503 all-trans retinal binding(GO:0005503)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 6.0 GO:0003823 antigen binding(GO:0003823)
0.0 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 2.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 3.9 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 3.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 2.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.3 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 2.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 3.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 3.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 3.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 2.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.3 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 4.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)