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Illumina Body Map 2
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Results for ALX1_ARX
Z-value: 0.72
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Transcription factors associated with ALX1_ARX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARX | hg19_v2_chrX_-_25034065_25034088 | 0.09 | 6.3e-01 | Click! |
| ALX1 | hg19_v2_chr12_+_85673868_85673885 | -0.07 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_95236551 Show fit | 4.62 |
ENST00000238558.3
|
goosecoid homeobox |
|
| chr14_+_22631122 Show fit | 4.61 |
ENST00000390458.3
|
T cell receptor alpha variable 29/delta variable 5 (gene/pseudogene) |
|
| chr3_-_27763803 Show fit | 2.76 |
ENST00000449599.1
|
eomesodermin |
|
| chr3_-_27764190 Show fit | 2.47 |
ENST00000537516.1
|
eomesodermin |
|
| chr5_+_96840389 Show fit | 2.39 |
ENST00000504012.1
|
RP11-1E3.1 |
|
| chr1_-_151148492 Show fit | 2.25 |
ENST00000295314.4
|
tropomodulin 4 (muscle) |
|
| chr1_-_151148442 Show fit | 2.23 |
ENST00000441701.1
ENST00000416280.2 |
tropomodulin 4 (muscle) |
|
| chr6_-_66417107 Show fit | 2.01 |
ENST00000370621.3
ENST00000370618.3 ENST00000503581.1 ENST00000393380.2 |
eyes shut homolog (Drosophila) |
|
| chr3_-_3151664 Show fit | 1.96 |
ENST00000256452.3
ENST00000311981.8 ENST00000430514.2 ENST00000456302.1 |
interleukin 5 receptor, alpha |
|
| chr12_+_54410664 Show fit | 1.91 |
ENST00000303406.4
|
homeobox C4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ALX1_ARX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 1.5 | 4.6 | GO:0014034 | neural crest cell fate commitment(GO:0014034) |
| 0.4 | 4.5 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.3 | 2.4 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.4 | 2.0 | GO:0038043 | interleukin-5-mediated signaling pathway(GO:0038043) |
| 0.1 | 2.0 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 2.0 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.1 | 1.7 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.5 | 1.6 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.1 | 1.6 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 2.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 1.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 1.5 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 0.3 | 1.3 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 1.1 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 0.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.9 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 0.9 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 5.1 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 3.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 2.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 2.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 2.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.4 | 2.0 | GO:0004914 | interleukin-5 receptor activity(GO:0004914) |
| 0.0 | 1.6 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.0 | 1.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.4 | 1.3 | GO:0070123 | transforming growth factor beta receptor activity, type III(GO:0070123) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 5.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 2.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.2 | REACTOME ADP SIGNALLING THROUGH P2RY1 | Genes involved in ADP signalling through P2Y purinoceptor 1 |
| 0.0 | 1.2 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.1 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 1.1 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.5 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |