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Illumina Body Map 2
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Results for ATF2_ATF1_ATF3
Z-value: 1.63
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Transcription factors associated with ATF2_ATF1_ATF3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115966.12 | activating transcription factor 2 | |
| ENSG00000123268.4 | activating transcription factor 1 | |
| ENSG00000162772.12 | activating transcription factor 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF3 | hg19_v2_chr1_+_212782012_212782257 | -0.67 | 2.4e-05 | Click! |
| ATF1 | hg19_v2_chr12_+_51158263_51158395 | 0.26 | 1.5e-01 | Click! |
| ATF2 | hg19_v2_chr2_-_176032843_176032941 | -0.18 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_139456226 Show fit | 7.91 |
ENST00000367658.2
|
headcase homolog (Drosophila) |
|
| chr19_+_1941117 Show fit | 4.95 |
ENST00000255641.8
|
casein kinase 1, gamma 2 |
|
| chr5_-_175965008 Show fit | 4.89 |
ENST00000537487.1
|
ring finger protein 44 |
|
| chr7_-_105926058 Show fit | 4.36 |
ENST00000417537.1
|
nicotinamide phosphoribosyltransferase |
|
| chr19_-_46088068 Show fit | 4.31 |
ENST00000263275.4
ENST00000323060.3 |
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) |
|
| chr11_-_77185094 Show fit | 4.31 |
ENST00000278568.4
ENST00000356341.3 |
p21 protein (Cdc42/Rac)-activated kinase 1 |
|
| chr7_-_142120321 Show fit | 4.21 |
ENST00000390377.1
|
T cell receptor beta variable 7-7 |
|
| chr7_-_140624499 Show fit | 3.96 |
ENST00000288602.6
|
v-raf murine sarcoma viral oncogene homolog B |
|
| chr7_+_142031986 Show fit | 3.94 |
ENST00000547918.2
|
T cell receptor beta variable 7-1 (non-functional) |
|
| chr6_-_34664612 Show fit | 3.84 |
ENST00000374023.3
ENST00000374026.3 |
chromosome 6 open reading frame 106 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 8.2 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.1 | 7.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 6.7 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161) |
| 0.1 | 6.6 | GO:0030148 | sphingolipid biosynthetic process(GO:0030148) |
| 0.1 | 6.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 6.2 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 6.2 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 6.1 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.7 | 6.0 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 32.2 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 27.1 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 18.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 16.5 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 14.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 12.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.3 | 10.2 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.1 | 8.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 8.4 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 8.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.3 | 14.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 12.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 10.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 8.4 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 7.7 | GO:0032182 | ubiquitin-like protein binding(GO:0032182) |
| 0.1 | 7.3 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 6.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 6.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 6.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 10.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 10.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 9.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 9.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 9.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 6.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 5.6 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 5.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.3 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 8.1 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 8.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 7.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 7.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 6.8 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 6.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 6.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 5.8 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 5.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |