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Illumina Body Map 2
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Results for ATF4
Z-value: 1.11
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Transcription factors associated with ATF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF4 | hg19_v2_chr22_+_39916558_39916579 | 0.26 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_41245160 Show fit | 6.14 |
ENST00000444189.2
ENST00000446533.3 |
ChaC, cation transport regulator homolog 1 (E. coli) |
|
| chr10_+_50507232 Show fit | 3.72 |
ENST00000374144.3
|
chromosome 10 open reading frame 71 |
|
| chr21_-_31864275 Show fit | 3.69 |
ENST00000334063.4
|
keratin associated protein 19-3 |
|
| chr8_-_38008783 Show fit | 3.49 |
ENST00000276449.4
|
steroidogenic acute regulatory protein |
|
| chr16_-_28550320 Show fit | 3.34 |
ENST00000395641.2
|
nuclear protein, transcriptional regulator, 1 |
|
| chr17_+_1665306 Show fit | 3.21 |
ENST00000571360.1
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
|
| chr10_+_50507181 Show fit | 3.17 |
ENST00000323868.4
|
chromosome 10 open reading frame 71 |
|
| chr1_-_178840157 Show fit | 3.09 |
ENST00000367629.1
ENST00000234816.2 |
angiopoietin-like 1 |
|
| chr16_-_28550348 Show fit | 2.88 |
ENST00000324873.6
|
nuclear protein, transcriptional regulator, 1 |
|
| chr17_-_79895097 Show fit | 2.71 |
ENST00000402252.2
ENST00000583564.1 ENST00000585244.1 ENST00000337943.5 ENST00000579698.1 |
pyrroline-5-carboxylate reductase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.0 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.3 | 6.2 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.3 | 6.1 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.8 | 5.3 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
| 0.0 | 3.7 | GO:0031424 | keratinization(GO:0031424) |
| 0.9 | 3.5 | GO:0018963 | insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963) |
| 0.3 | 3.0 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.1 | 2.6 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 2.3 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.4 | 2.0 | GO:1904640 | response to methionine(GO:1904640) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.0 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 6.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 5.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 3.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 3.5 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.3 | 3.0 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 3.0 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 2.1 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.2 | 1.5 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 1.3 | GO:0071953 | elastic fiber(GO:0071953) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.5 | 6.1 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.9 | 5.3 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 3.5 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.3 | 3.0 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.0 | 2.4 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 2.0 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 1.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.6 | 1.8 | GO:0004817 | cysteine-tRNA ligase activity(GO:0004817) |
| 0.3 | 1.8 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.5 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 8.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 3.5 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 1.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.8 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.8 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.5 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |