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Illumina Body Map 2
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Results for BPTF
Z-value: 2.05
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Transcription factors associated with BPTF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BPTF | hg19_v2_chr17_+_65821636_65821641 | 0.13 | 4.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_55653259 Show fit | 3.19 |
ENST00000593194.1
|
troponin T type 1 (skeletal, slow) |
|
| chr12_-_111358372 Show fit | 3.18 |
ENST00000548438.1
ENST00000228841.8 |
myosin, light chain 2, regulatory, cardiac, slow |
|
| chr10_-_61513201 Show fit | 3.10 |
ENST00000414264.1
ENST00000594536.1 |
long intergenic non-protein coding RNA 948 |
|
| chrX_-_15332665 Show fit | 3.08 |
ENST00000537676.1
ENST00000344384.4 |
ankyrin repeat and SOCS box containing 11 |
|
| chr6_+_53976211 Show fit | 2.99 |
ENST00000503951.1
|
muscular LMNA-interacting protein |
|
| chr17_-_10452929 Show fit | 2.92 |
ENST00000532183.2
ENST00000397183.2 ENST00000420805.1 |
myosin, heavy chain 2, skeletal muscle, adult |
|
| chr3_-_196242233 Show fit | 2.83 |
ENST00000397537.2
|
single-pass membrane protein with coiled-coil domains 1 |
|
| chr10_-_61513146 Show fit | 2.68 |
ENST00000430431.1
|
long intergenic non-protein coding RNA 948 |
|
| chr7_-_150329421 Show fit | 2.67 |
ENST00000493969.1
ENST00000328902.5 |
GTPase, IMAP family member 6 |
|
| chr6_+_53976235 Show fit | 2.57 |
ENST00000502396.1
ENST00000358276.5 |
muscular LMNA-interacting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of BPTF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.8 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 8.4 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 6.6 | GO:0007030 | Golgi organization(GO:0007030) |
| 1.6 | 6.5 | GO:1901846 | positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846) |
| 0.0 | 6.4 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.1 | 6.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 5.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.1 | 5.4 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 5.0 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
| 0.4 | 4.8 | GO:2000332 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 13.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 12.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.3 | 11.7 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 8.8 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 8.6 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 8.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 8.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 7.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 7.5 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 10.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 8.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 7.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 6.1 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 5.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 5.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 5.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 5.1 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 5.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 9.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 9.1 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.2 | 8.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 8.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 6.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.1 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 5.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 5.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 5.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 14.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 11.8 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 11.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 8.9 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.2 | 8.8 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 8.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 7.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 6.4 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 6.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |