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Illumina Body Map 2
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Results for BRCA1
Z-value: 0.51
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Transcription factors associated with BRCA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BRCA1 | hg19_v2_chr17_-_41277370_41277419 | 0.34 | 5.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_41738931 Show fit | 1.04 |
ENST00000329168.3
ENST00000549132.1 |
mesenchyme homeobox 1 |
|
| chr17_-_41739283 Show fit | 1.01 |
ENST00000393661.2
ENST00000318579.4 |
mesenchyme homeobox 1 |
|
| chr14_-_60097524 Show fit | 1.00 |
ENST00000342503.4
|
reticulon 1 |
|
| chr14_-_60097297 Show fit | 0.97 |
ENST00000395090.1
|
reticulon 1 |
|
| chr2_+_196522032 Show fit | 0.82 |
ENST00000418005.1
|
solute carrier family 39 (zinc transporter), member 10 |
|
| chr6_+_12717892 Show fit | 0.76 |
ENST00000379350.1
|
phosphatase and actin regulator 1 |
|
| chr6_-_110797799 Show fit | 0.72 |
ENST00000456137.2
ENST00000368919.3 ENST00000439654.1 |
solute carrier family 22 (organic cation/carnitine transporter), member 16 |
|
| chr6_+_123100620 Show fit | 0.71 |
ENST00000368444.3
|
fatty acid binding protein 7, brain |
|
| chr19_-_48059113 Show fit | 0.66 |
ENST00000391901.3
ENST00000314121.4 ENST00000448976.1 |
zinc finger protein 541 |
|
| chr2_-_158182322 Show fit | 0.66 |
ENST00000420719.2
ENST00000409216.1 |
ermin, ERM-like protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of BRCA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.5 | GO:1903615 | regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615) |
| 0.3 | 2.1 | GO:0001757 | somite specification(GO:0001757) sclerotome development(GO:0061056) |
| 0.1 | 1.6 | GO:1902603 | carnitine transmembrane transport(GO:1902603) |
| 0.0 | 1.0 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
| 0.0 | 0.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 0.7 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.0 | 0.7 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.0 | 0.7 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.2 | 0.5 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 0.5 | GO:0002305 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 1.0 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.1 | 0.7 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.3 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 0.3 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.2 | GO:1990075 | kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075) |
| 0.0 | 0.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 2.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.3 | 1.6 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
| 0.0 | 1.0 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 0.5 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.4 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 0.3 | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity(GO:0034602) |
| 0.0 | 0.3 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.6 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 1.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.7 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |