Illumina Body Map 2


Results for CBFB

Z-value: 0.68

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_43343886 2.54 ENST00000190983.4
WNT1 inducible signaling pathway protein 2
chr6_-_75912508 2.09 ENST00000416123.2
collagen, type XII, alpha 1
chr22_+_23222886 2.04 ENST00000390319.2
immunoglobulin lambda variable 3-1
chr14_-_61116168 1.97 ENST00000247182.6
SIX homeobox 1
chr1_+_47264711 1.94 ENST00000371923.4
cytochrome P450, family 4, subfamily B, polypeptide 1
chr20_+_44637526 1.61 ENST00000372330.3
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr3_-_99569821 1.40 ENST00000487087.1
filamin A interacting protein 1-like
chr4_+_71091786 1.29 ENST00000317987.5
follicular dendritic cell secreted protein
chr14_-_24977457 1.21 ENST00000250378.3
chymase 1, mast cell
chr2_-_158300556 1.19 ENST00000264192.3
cytohesin 1 interacting protein
chr8_+_104384616 1.11 ENST00000520337.1
collagen triple helix repeat containing 1
chr2_+_173955327 1.03 ENST00000422149.1
Mitogen-activated protein kinase kinase kinase MLT
chr17_-_34417479 0.99 ENST00000225245.5
chemokine (C-C motif) ligand 3
chr7_+_120628731 0.96 ENST00000310396.5
cadherin-like and PC-esterase domain containing 1
chr15_+_49715449 0.90 ENST00000560979.1
fibroblast growth factor 7
chr11_-_1912084 0.85 ENST00000391480.1
chromosome 11 open reading frame 89
chr14_+_22919081 0.81 ENST00000390473.1
T cell receptor delta joining 1
chr12_-_68553512 0.75 ENST00000229135.3
interferon, gamma
chr12_-_53575120 0.67 ENST00000542115.1
cysteine sulfinic acid decarboxylase
chr3_+_157154578 0.64 ENST00000295927.3
pentraxin 3, long
chr3_-_71834318 0.63 ENST00000353065.3
prokineticin 2
chrX_+_68048803 0.61 ENST00000204961.4
chr14_+_85996471 0.61 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr15_+_49715293 0.61 ENST00000267843.4
fibroblast growth factor 7
chr2_+_68592305 0.58 ENST00000234313.7
chr1_+_159770292 0.57 ENST00000536257.1
Fc receptor-like 6
chr9_-_130541017 0.56 ENST00000314830.8
SH2 domain containing 3C
chr3_-_71834207 0.56 ENST00000295619.3
prokineticin 2
chr1_+_196621156 0.55 ENST00000359637.2
complement factor H
chr14_+_22748980 0.54 ENST00000390465.2
T cell receptor alpha variable 38-2/delta variable 8
chr2_-_64881018 0.53 ENST00000313349.3
SERTA domain containing 2
chr10_-_29811456 0.53 ENST00000535393.1
chr17_+_1633755 0.51 ENST00000545662.1
WD repeat domain 81
chr14_+_85996507 0.50 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr11_-_66103932 0.50 ENST00000311320.4
Ras and Rab interactor 1
chr15_+_73976545 0.50 ENST00000318443.5
CD276 molecule
chr5_+_35856951 0.49 ENST00000303115.3
interleukin 7 receptor
chr11_-_66103867 0.43 ENST00000424433.2
Ras and Rab interactor 1
chr6_-_113953705 0.42 ENST00000452675.1
chr11_+_114310102 0.41 ENST00000265881.5
RNA exonuclease 2
chr18_-_53089723 0.41 ENST00000561992.1
transcription factor 4
chrX_+_115567767 0.41 ENST00000371900.4
solute carrier family 6 (amino acid transporter), member 14
chr1_+_196621002 0.39 ENST00000367429.4
complement factor H
chr20_+_54987168 0.36 ENST00000360314.3
Cas scaffolding protein family member 4
chrX_-_153718988 0.35 ENST00000263512.4
solute carrier family 10, member 3
chrX_-_49041242 0.34 ENST00000453382.1
prickle homolog 3 (Drosophila)
chr11_+_114310164 0.33 ENST00000544196.1
RNA exonuclease 2
chr2_+_103035102 0.33 ENST00000264260.2
interleukin 18 receptor accessory protein
chr3_-_11610255 0.32 ENST00000424529.2
vestigial like 4 (Drosophila)
chr11_-_66104237 0.31 ENST00000530056.1
Ras and Rab interactor 1
chr11_+_114310237 0.29 ENST00000539119.1
RNA exonuclease 2
chr15_+_67390920 0.29 ENST00000559092.1
SMAD family member 3
chr2_+_207024306 0.29 ENST00000236957.5
eukaryotic translation elongation factor 1 beta 2
chr18_-_53089538 0.28 ENST00000566777.1
transcription factor 4
chr2_-_87248975 0.27 ENST00000409310.2
plasminogen-like B1
chr6_+_30908747 0.26 ENST00000462446.1
diffuse panbronchiolitis critical region 1
chr1_+_209859510 0.25 ENST00000367028.2
hydroxysteroid (11-beta) dehydrogenase 1
chrX_-_70838306 0.24 ENST00000373691.4
chemokine (C-X-C motif) receptor 3
chr3_+_132843652 0.23 ENST00000508711.1
transmembrane protein 108
chr6_+_27925019 0.23 ENST00000244623.1
olfactory receptor, family 2, subfamily B, member 6
chr21_-_36421535 0.23 ENST00000416754.1
runt-related transcription factor 1
chr1_+_89246647 0.23 ENST00000544045.1
protein kinase N2
chr14_-_59951112 0.22 ENST00000247194.4
L-3-hydroxyproline dehydratase (trans-)
chr2_+_234826016 0.22 ENST00000324695.4
transient receptor potential cation channel, subfamily M, member 8
chr11_-_64885111 0.20 ENST00000528598.1
zinc finger, HIT-type containing 2
chr1_-_52499443 0.19 ENST00000371614.1
KTI12 homolog, chromatin associated (S. cerevisiae)
chr20_+_62492566 0.18 ENST00000369916.3
abhydrolase domain containing 16B
chr11_-_58343319 0.18 ENST00000395074.2
chr21_-_36421626 0.18 ENST00000300305.3
runt-related transcription factor 1
chr12_+_25205568 0.17 ENST00000548766.1
lymphoid-restricted membrane protein
chr17_+_75316336 0.16 ENST00000591934.1
septin 9
chr21_-_36421401 0.15 ENST00000486278.2
runt-related transcription factor 1
chr6_+_52051171 0.15 ENST00000340057.1
interleukin 17A
chr14_-_85996332 0.15 ENST00000380722.1
chr14_+_22959438 0.14 ENST00000390489.1
T cell receptor alpha joining 48
chr20_+_54987305 0.13 ENST00000371336.3
Cas scaffolding protein family member 4
chr1_-_184723942 0.13 ENST00000318130.8
ER degradation enhancer, mannosidase alpha-like 3
chr12_-_53594227 0.12 ENST00000550743.2
integrin, beta 7
chr6_-_34524093 0.12 ENST00000544425.1
SAM pointed domain containing ETS transcription factor
chr8_-_28747424 0.11 ENST00000523436.1
integrator complex subunit 9
chrX_-_19688475 0.11 ENST00000541422.1
SH3-domain kinase binding protein 1
chr6_-_34524049 0.11 ENST00000374037.3
SAM pointed domain containing ETS transcription factor
chr21_+_35107346 0.09 ENST00000456489.1
intersectin 1 (SH3 domain protein)
chr3_-_147123837 0.09 ENST00000462748.2
Zic family member 4
chr14_-_59950724 0.08 ENST00000481608.1
L-3-hydroxyproline dehydratase (trans-)
chr9_-_35079911 0.07 ENST00000448890.1
Fanconi anemia, complementation group G
chr6_+_42847649 0.07 ENST00000424341.2
ribosomal protein L7-like 1
chr3_+_187957646 0.06 ENST00000457242.1
LIM domain containing preferred translocation partner in lipoma
chr8_-_28747717 0.06 ENST00000416984.2
integrator complex subunit 9
chr22_+_42665742 0.03 ENST00000332965.3
chr2_-_127977654 0.03 ENST00000409327.1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr16_+_53088885 0.02 ENST00000566029.1
chromodomain helicase DNA binding protein 9
chr19_-_14049184 0.02 ENST00000339560.5
podocan-like 1
chr8_-_134072593 0.02 ENST00000427060.2
chr1_+_17634689 0.02 ENST00000375453.1
peptidyl arginine deiminase, type IV
chr12_-_52585765 0.02 ENST00000313234.5
keratin 80
chr12_-_4754356 0.01 ENST00000540967.1
A kinase (PRKA) anchor protein 3
chr1_+_248058889 0.00 ENST00000360358.3
olfactory receptor, family 2, subfamily W, member 3
chr1_-_157014865 0.00 ENST00000361409.2
Rho guanine nucleotide exchange factor (GEF) 11
chr17_+_32582293 0.00 ENST00000580907.1
chemokine (C-C motif) ligand 2

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.5 2.0 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.4 1.2 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.3 0.8 GO:2000309 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.2 1.6 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.2 1.9 GO:0018879 biphenyl metabolic process(GO:0018879)
0.2 1.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 1.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 1.1 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.1 0.7 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 1.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.6 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1 0.6 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 2.1 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 1.2 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.0 0.2 GO:0097106 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) postsynaptic density organization(GO:0097106)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 1.0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 2.0 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.2 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 2.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 1.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.7 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.1 0.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.3 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 2.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.9 GO:0070330 aromatase activity(GO:0070330)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.7 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 4.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 3.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.3 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.5 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.7 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 1.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters