ISMARA results: CDX2

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Illumina Body Map 2

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Results for CDX2

Z-value: 0.81

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Transcription factors associated with CDX2

Gene Symbol	Gene ID	Gene Info
CDX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000165556.9	caudal type homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CDX2	hg19_v2_chr13_-_28545276_28545276	-0.29	1.1e-01	Click!

Activity profile of CDX2 motif

Sorted Z-values of CDX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_+_105937068 Show fit	1.67	ENST00000324342.3	RNF128 Ensembl NCBI GeneCards UniProt NextProt Show fit	ring finger protein 128, E3 ubiquitin protein ligase
chr1_-_237167718 Show fit	1.66	ENST00000464121.2	MT1HL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 1H-like 1
chrX_+_105936982 Show fit	1.60	ENST00000418562.1	RNF128 Ensembl NCBI GeneCards UniProt NextProt Show fit	ring finger protein 128, E3 ubiquitin protein ligase
chr22_+_32455111 Show fit	1.59	ENST00000543737.1	SLC5A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 5 (sodium/glucose cotransporter), member 1
chr14_+_39944025 Show fit	1.33	ENST00000554328.1 ENST00000556620.1 ENST00000557197.1	RP11-111A21.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-111A21.1
chr12_-_112443767 Show fit	1.26	ENST00000550233.1 ENST00000546962.1 ENST00000550800.2	TMEM116 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 116
chr10_-_94301107 Show fit	1.26	ENST00000436178.1	IDE Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin-degrading enzyme
chr12_-_112443830 Show fit	1.26	ENST00000550037.1 ENST00000549425.1	TMEM116 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 116
chrM_+_10464 Show fit	1.17	ENST00000361335.1	MT-ND4L Ensembl NCBI GeneCards UniProt NextProt Show fit	mitochondrially encoded NADH dehydrogenase 4L
chr10_-_103599591 Show fit	1.14	ENST00000348850.5	KCNIP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Kv channel interacting protein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.3	GO:1904352	positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0	2.6	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2	1.8	GO:2000332	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2	1.7	GO:0070779	gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2	1.6	GO:0001951	intestinal D-glucose absorption(GO:0001951)
0.1	1.6	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	1.6	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.0	1.6	GO:0030262	apoptotic nuclear changes(GO:0030262)
0.1	1.4	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3	1.1	GO:0006428	isoleucyl-tRNA aminoacylation(GO:0006428)

Showing 1 to 10 of 82 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	2.3	GO:0016605	PML body(GO:0016605)
0.0	1.9	GO:0031526	brush border membrane(GO:0031526)
0.0	1.9	GO:0016459	myosin complex(GO:0016459)
0.1	1.8	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.0	1.8	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	1.6	GO:0005577	fibrinogen complex(GO:0005577)
0.0	1.6	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	0.9	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.8	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2	1.8	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.2	1.7	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.2	1.6	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.4	1.3	GO:0031626	beta-endorphin binding(GO:0031626)
0.3	1.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.3	1.1	GO:0004822	isoleucine-tRNA ligase activity(GO:0004822)
0.1	1.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.1	1.1	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.1	1.0	GO:0097109	neuroligin family protein binding(GO:0097109)

Showing 1 to 10 of 60 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.8	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
2.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
1.6	PID CONE PATHWAY	Visual signal transduction: Cones
1.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.7	ST STAT3 PATHWAY	STAT3 Pathway
0.7	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.4	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3	ST GA12 PATHWAY	G alpha 12 Pathway

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	2.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	2.0	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.1	1.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.0	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	0.8	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.8	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.7	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.6	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.6	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling

Showing 1 to 10 of 18 entries

Results for CDX2

Z-value: 0.81

Motif logo

Transcription factors associated with CDX2

Activity-expression correlation:

Activity profile of CDX2 motif

Sorted Z-values of CDX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: