ISMARA results: CLOCK

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Illumina Body Map 2

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Results for CLOCK

Z-value: 1.57

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Transcription factors associated with CLOCK

Gene Symbol	Gene ID	Gene Info
CLOCK Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134852.10	clock circadian regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CLOCK	hg19_v2_chr4_-_56412713_56412799	-0.30	9.0e-02	Click!

Activity profile of CLOCK motif

Sorted Z-values of CLOCK motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_23877474 Show fit	5.07	ENST00000405093.3	MYH6 Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin, heavy chain 6, cardiac muscle, alpha
chr14_-_23876801 Show fit	4.90	ENST00000356287.3	MYH6 Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin, heavy chain 6, cardiac muscle, alpha
chr16_+_56703703 Show fit	4.26	ENST00000332374.4	MT1H Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 1H
chr18_-_3220106 Show fit	3.79	ENST00000356443.4 ENST00000400569.3	MYOM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	myomesin 1
chr16_+_56703737 Show fit	3.58	ENST00000569155.1	MT1H Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 1H
chr12_-_103310987 Show fit	3.33	ENST00000307000.2	PAH Ensembl NCBI GeneCards UniProt NextProt Show fit	phenylalanine hydroxylase
chr1_-_40137710 Show fit	3.21	ENST00000235628.1	NT5C1A Ensembl NCBI GeneCards UniProt NextProt Show fit	5'-nucleotidase, cytosolic IA
chr16_-_81129845 Show fit	3.08	ENST00000569885.1 ENST00000566566.1	GCSH Ensembl NCBI GeneCards UniProt NextProt Show fit	glycine cleavage system protein H (aminomethyl carrier)
chr22_+_18593097 Show fit	2.85	ENST00000426208.1	TUBA8 Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin, alpha 8
chr4_+_74275057 Show fit	2.57	ENST00000511370.1	ALB Ensembl NCBI GeneCards UniProt NextProt Show fit	albumin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CLOCK

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	10.5	GO:0003228	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.2	7.8	GO:0071294	cellular response to zinc ion(GO:0071294)
0.8	7.7	GO:0019264	glycine biosynthetic process from serine(GO:0019264)
1.2	5.9	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.6	5.8	GO:0006552	leucine catabolic process(GO:0006552)
0.9	5.4	GO:0019470	4-hydroxyproline catabolic process(GO:0019470)
0.1	5.3	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1	5.1	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1	4.7	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.3	4.0	GO:0070257	positive regulation of mucus secretion(GO:0070257)

Showing 1 to 10 of 268 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	15.7	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	10.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.3	9.8	GO:0032982	myosin filament(GO:0032982)
0.8	7.7	GO:0070552	BRISC complex(GO:0070552)
1.5	5.9	GO:0005863	striated muscle myosin thick filament(GO:0005863)
1.0	5.8	GO:1905202	3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.0	5.6	GO:0030018	Z disc(GO:0030018)
0.3	5.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	4.4	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.0	3.8	GO:0005746	mitochondrial respiratory chain(GO:0005746)

Showing 1 to 10 of 121 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.1	10.0	GO:0017018	myosin phosphatase activity(GO:0017018)
0.8	7.7	GO:0008732	glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2	6.3	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
1.0	5.8	GO:0004485	methylcrotonoyl-CoA carboxylase activity(GO:0004485)
1.8	5.4	GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.2	5.1	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	4.8	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	4.2	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2	3.9	GO:0008253	5'-nucleotidase activity(GO:0008253)

Showing 1 to 10 of 216 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
2.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
2.1	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
1.7	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
1.7	PID CMYB PATHWAY	C-MYB transcription factor network
1.4	PID FOXO PATHWAY	FoxO family signaling
1.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
1.3	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
1.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development

Showing 1 to 10 of 35 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	9.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	6.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.2	5.7	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.2	5.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.2	5.1	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.2	4.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	3.9	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	3.5	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	3.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism

Showing 1 to 10 of 78 entries

Results for CLOCK

Z-value: 1.57

Motif logo

Transcription factors associated with CLOCK

Activity-expression correlation:

Activity profile of CLOCK motif

Sorted Z-values of CLOCK motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CLOCK

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: