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Illumina Body Map 2
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Results for CUX1
Z-value: 1.71
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Transcription factors associated with CUX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CUX1 | hg19_v2_chr7_+_101459263_101459310 | -0.47 | 6.6e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 33.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.3 | 28.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 11.8 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.1 | 10.7 | GO:0031295 | lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295) |
| 0.1 | 9.6 | GO:0002455 | humoral immune response mediated by circulating immunoglobulin(GO:0002455) |
| 0.0 | 9.4 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.0 | 8.3 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 1.2 | 7.1 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.3 | 7.1 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.8 | 6.1 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 21.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.3 | 17.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 8.6 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 7.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 5.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 5.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 4.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 3.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 3.7 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 47.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 27.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 9.2 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
| 0.7 | 6.8 | GO:0019863 | IgE binding(GO:0019863) |
| 1.2 | 6.1 | GO:0004911 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 0.8 | 5.8 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.0 | 5.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 5.6 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 5.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 5.5 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.6 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 15.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 6.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 6.0 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 5.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 4.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 4.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 3.2 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 3.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.1 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 22.0 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 17.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 8.4 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.1 | 7.4 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.2 | 5.8 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 5.8 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.2 | 4.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 4.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 3.4 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.1 | 3.0 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |