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Illumina Body Map 2
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Results for CUX2
Z-value: 1.50
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Transcription factors associated with CUX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CUX2 | hg19_v2_chr12_+_111537227_111537250 | 0.71 | 4.9e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_196912902 Show fit | 5.31 |
ENST00000476712.2
ENST00000367415.5 |
complement factor H-related 2 |
|
| chr17_-_64216748 Show fit | 4.33 |
ENST00000585162.1
|
apolipoprotein H (beta-2-glycoprotein I) |
|
| chr1_-_75100539 Show fit | 4.08 |
ENST00000420661.2
|
chromosome 1 open reading frame 173 |
|
| chr19_-_58864848 Show fit | 3.87 |
ENST00000263100.3
|
alpha-1-B glycoprotein |
|
| chr3_+_35683651 Show fit | 3.84 |
ENST00000187397.4
|
cAMP-regulated phosphoprotein, 21kDa |
|
| chr18_+_29171689 Show fit | 3.75 |
ENST00000237014.3
|
transthyretin |
|
| chr3_+_35721106 Show fit | 3.58 |
ENST00000474696.1
ENST00000412048.1 ENST00000396482.2 ENST00000432682.1 |
cAMP-regulated phosphoprotein, 21kDa |
|
| chr4_+_74275057 Show fit | 3.57 |
ENST00000511370.1
|
albumin |
|
| chr13_-_46679185 Show fit | 3.44 |
ENST00000439329.3
|
carboxypeptidase B2 (plasma) |
|
| chr1_-_159684371 Show fit | 3.31 |
ENST00000255030.5
ENST00000437342.1 ENST00000368112.1 ENST00000368111.1 ENST00000368110.1 ENST00000343919.2 |
C-reactive protein, pentraxin-related |
Network of associatons between targets according to the STRING database.
First level regulatory network of CUX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.4 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.6 | 6.8 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 1.6 | 6.5 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.4 | 5.8 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.0 | 5.4 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 0.3 | 5.0 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.2 | 4.4 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.4 | 4.1 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.8 | 3.9 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 1.3 | 3.8 | GO:1903718 | carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 9.1 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 5.9 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 4.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 4.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 3.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 3.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 3.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 2.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 2.5 | GO:0030658 | transport vesicle membrane(GO:0030658) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.2 | 7.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 1.0 | 6.8 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 5.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 4.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.9 | 4.4 | GO:0033265 | choline binding(GO:0033265) |
| 0.0 | 4.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.0 | 4.1 | GO:1904493 | Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493) |
| 0.0 | 3.9 | GO:0004540 | ribonuclease activity(GO:0004540) |
| 0.9 | 3.8 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 7.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 6.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 3.9 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 3.4 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 3.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 2.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 1.8 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 6.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.3 | 5.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 5.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 3.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 3.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 3.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 3.1 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 3.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 3.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |