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Illumina Body Map 2
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Results for DBX2_HLX
Z-value: 1.05
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Transcription factors associated with DBX2_HLX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HLX | hg19_v2_chr1_+_221054411_221054411 | -0.65 | 5.6e-05 | Click! |
| DBX2 | hg19_v2_chr12_-_45444873_45444888 | 0.24 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_13517565 Show fit | 3.28 |
ENST00000282091.1
ENST00000529816.1 |
parathyroid hormone |
|
| chr10_+_69865866 Show fit | 3.25 |
ENST00000354393.2
|
myopalladin |
|
| chr12_-_10978957 Show fit | 2.73 |
ENST00000240619.2
|
taste receptor, type 2, member 10 |
|
| chr9_-_28670283 Show fit | 2.40 |
ENST00000379992.2
|
leucine rich repeat and Ig domain containing 2 |
|
| chr11_-_26593649 Show fit | 2.04 |
ENST00000455601.2
|
mucin 15, cell surface associated |
|
| chrX_-_73072534 Show fit | 1.97 |
ENST00000429829.1
|
X inactive specific transcript (non-protein coding) |
|
| chr7_+_123241908 Show fit | 1.95 |
ENST00000434204.1
ENST00000437535.1 ENST00000451215.1 |
ankyrin repeat and SOCS box containing 15 |
|
| chr11_-_26593779 Show fit | 1.94 |
ENST00000529533.1
|
mucin 15, cell surface associated |
|
| chr2_+_182850551 Show fit | 1.89 |
ENST00000452904.1
ENST00000409137.3 ENST00000280295.3 |
protein phosphatase 1, regulatory (inhibitor) subunit 1C |
|
| chr6_-_25874440 Show fit | 1.82 |
ENST00000361703.6
ENST00000397060.4 |
solute carrier family 17 (organic anion transporter), member 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBX2_HLX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.2 | 4.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 1.1 | 3.3 | GO:1900158 | negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.4 | 2.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.1 | 2.7 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 2.4 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.1 | 2.3 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.2 | 2.0 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 1.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.6 | 1.8 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 5.1 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 4.6 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 2.9 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 2.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 2.5 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 1.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 1.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 1.3 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 1.2 | GO:0044305 | calyx of Held(GO:0044305) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 3.3 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.1 | 3.1 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 2.9 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 2.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.2 | 2.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.3 | 2.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.2 | 2.3 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 2.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 2.1 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.0 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 5.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 4.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 4.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 2.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 2.2 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |