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Illumina Body Map 2
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Results for DLX3_EVX1_MEOX1
Z-value: 0.66
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Transcription factors associated with DLX3_EVX1_MEOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEOX1 | hg19_v2_chr17_-_41738931_41739040 | 0.21 | 2.4e-01 | Click! |
| EVX1 | hg19_v2_chr7_+_27282319_27282394 | -0.18 | 3.1e-01 | Click! |
| DLX3 | hg19_v2_chr17_-_48072574_48072597 | 0.04 | 8.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_6233828 Show fit | 1.40 |
ENST00000572068.1
ENST00000261405.5 |
von Willebrand factor |
|
| chr4_-_36245561 Show fit | 1.38 |
ENST00000506189.1
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
|
| chr14_+_22748980 Show fit | 1.37 |
ENST00000390465.2
|
T cell receptor alpha variable 38-2/delta variable 8 |
|
| chr5_-_115890554 Show fit | 1.34 |
ENST00000509665.1
|
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
|
| chr7_-_111424462 Show fit | 1.18 |
ENST00000437129.1
|
dedicator of cytokinesis 4 |
|
| chr13_+_58206655 Show fit | 1.17 |
ENST00000377918.3
|
protocadherin 17 |
|
| chr6_+_151646800 Show fit | 1.14 |
ENST00000354675.6
|
A kinase (PRKA) anchor protein 12 |
|
| chr4_-_138453606 Show fit | 1.09 |
ENST00000412923.2
ENST00000344876.4 ENST00000507846.1 ENST00000510305.1 |
protocadherin 18 |
|
| chr7_-_111424506 Show fit | 1.07 |
ENST00000450156.1
ENST00000494651.2 |
dedicator of cytokinesis 4 |
|
| chr18_-_53019208 Show fit | 1.05 |
ENST00000562607.1
|
transcription factor 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX3_EVX1_MEOX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.5 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.3 | 2.3 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.1 | 1.5 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.0 | 1.5 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 1.3 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.4 | 1.2 | GO:1990709 | presynaptic active zone organization(GO:1990709) |
| 0.1 | 1.2 | GO:2000334 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 1.2 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 1.2 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.3 | 1.0 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.4 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 3.9 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.2 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.0 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.7 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 0.6 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 0.6 | GO:0032584 | growth cone membrane(GO:0032584) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 2.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 2.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 1.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 1.6 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.1 | 1.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 1.3 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 1.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 1.2 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 1.0 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 2.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 1.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 1.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 1.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 1.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 1.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.9 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |