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Illumina Body Map 2
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Results for DLX4_HOXD8
Z-value: 2.00
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Transcription factors associated with DLX4_HOXD8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD8 | hg19_v2_chr2_+_176995011_176995085 | -0.42 | 1.8e-02 | Click! |
| DLX4 | hg19_v2_chr17_+_48046671_48046697 | -0.21 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_158345341 Show fit | 11.50 |
ENST00000435117.1
|
cytohesin 1 interacting protein |
|
| chr15_-_22448819 Show fit | 9.71 |
ENST00000604066.1
|
immunoglobulin heavy variable 1/OR15-1 (non-functional) |
|
| chr17_-_64225508 Show fit | 9.21 |
ENST00000205948.6
|
apolipoprotein H (beta-2-glycoprotein I) |
|
| chr14_+_22337014 Show fit | 8.76 |
ENST00000390436.2
|
T cell receptor alpha variable 13-1 |
|
| chr1_-_183538319 Show fit | 8.45 |
ENST00000420553.1
ENST00000419402.1 |
neutrophil cytosolic factor 2 |
|
| chr14_+_22580233 Show fit | 8.34 |
ENST00000390454.2
|
T cell receptor alpha variable 25 |
|
| chr5_-_55412774 Show fit | 8.33 |
ENST00000434982.2
|
ankyrin repeat domain 55 |
|
| chr10_+_7745303 Show fit | 7.88 |
ENST00000429820.1
ENST00000379587.4 |
inter-alpha-trypsin inhibitor heavy chain 2 |
|
| chr12_-_10151773 Show fit | 7.66 |
ENST00000298527.6
ENST00000348658.4 |
C-type lectin domain family 1, member B |
|
| chr14_+_22631122 Show fit | 7.38 |
ENST00000390458.3
|
T cell receptor alpha variable 29/delta variable 5 (gene/pseudogene) |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX4_HOXD8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 158.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 64.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.0 | 46.8 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 32.3 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 1.9 | 26.8 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.4 | 20.6 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 1.4 | 19.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 15.8 | GO:0002228 | natural killer cell mediated immunity(GO:0002228) |
| 1.0 | 14.4 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.8 | 13.7 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 84.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 51.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 45.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 25.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.5 | 21.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 16.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 16.0 | GO:0005769 | early endosome(GO:0005769) |
| 0.2 | 15.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.8 | 15.2 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 15.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 151.4 | GO:0003823 | antigen binding(GO:0003823) |
| 1.2 | 61.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.8 | 50.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 2.9 | 20.5 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 20.3 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.5 | 17.6 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.6 | 17.1 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 15.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 2.3 | 13.7 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.4 | 13.0 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 19.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 18.4 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 18.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 15.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 14.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 14.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.2 | 14.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 12.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 11.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 49.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.4 | 31.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.5 | 27.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 19.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 19.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 19.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 15.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.5 | 14.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.4 | 13.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.3 | 13.6 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |