ISMARA results: DMC1

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Illumina Body Map 2

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Results for DMC1

Z-value: 0.78

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Transcription factors associated with DMC1

Gene Symbol	Gene ID	Gene Info
DMC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000100206.5	DNA meiotic recombinase 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
DMC1	hg19_v2_chr22_-_38966123_38966163	0.17	3.6e-01	Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_69865866 Show fit	3.94	ENST00000354393.2	MYPN Ensembl NCBI GeneCards UniProt NextProt Show fit	myopalladin
chr5_+_94727048 Show fit	2.43	ENST00000283357.5	FAM81B Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 81, member B
chr7_-_150884332 Show fit	2.04	ENST00000275838.1 ENST00000422024.1 ENST00000434669.1	ASB10 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin repeat and SOCS box containing 10
chr2_-_75788038 Show fit	1.99	ENST00000393913.3 ENST00000410113.1	EVA1A Ensembl NCBI GeneCards UniProt NextProt Show fit	eva-1 homolog A (C. elegans)
chr20_+_123010 Show fit	1.91	ENST00000382398.3	DEFB126 Ensembl NCBI GeneCards UniProt NextProt Show fit	defensin, beta 126
chr1_+_166958346 Show fit	1.80	ENST00000367872.4	MAEL Ensembl NCBI GeneCards UniProt NextProt Show fit	maelstrom spermatogenic transposon silencer
chr3_+_148457585 Show fit	1.77	ENST00000402260.1	AGTR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	angiotensin II receptor, type 1
chr2_+_171640291 Show fit	1.71	ENST00000409885.1	ERICH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate-rich 2
chr2_+_120187465 Show fit	1.69	ENST00000409826.1 ENST00000417645.1	TMEM37 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 37
chr1_+_166958497 Show fit	1.69	ENST00000367870.2	MAEL Ensembl NCBI GeneCards UniProt NextProt Show fit	maelstrom spermatogenic transposon silencer

Showing 1 to 10 of 100 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.0	GO:0034587	piRNA metabolic process(GO:0034587)
0.2	3.9	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.9	2.8	GO:0001869	regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.1	2.6	GO:0044458	motile cilium assembly(GO:0044458)
0.1	2.3	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.4	1.8	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.5	1.6	GO:0042700	luteinizing hormone signaling pathway(GO:0042700)
0.2	1.6	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1	1.4	GO:0006702	androgen biosynthetic process(GO:0006702)
0.2	1.3	GO:0009253	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)

Showing 1 to 10 of 33 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	5.0	GO:0030849	autosome(GO:0030849)
0.0	4.2	GO:0030018	Z disc(GO:0030018)
0.2	2.9	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	2.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	2.3	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.1	1.7	GO:0033391	chromatoid body(GO:0033391)
0.0	1.6	GO:0005581	collagen trimer(GO:0005581)
0.0	1.3	GO:0002080	acrosomal membrane(GO:0002080)
0.0	1.3	GO:0045095	keratin filament(GO:0045095)
0.4	1.2	GO:0034685	integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.9	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	2.9	GO:0051018	protein kinase A binding(GO:0051018)
0.4	2.8	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.3	2.3	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	1.9	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.6	1.8	GO:0001596	angiotensin type I receptor activity(GO:0001596)
0.4	1.6	GO:0004963	follicle-stimulating hormone receptor activity(GO:0004963)
0.0	1.6	GO:0005518	collagen binding(GO:0005518)
0.1	1.4	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.1	1.3	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.4	PID ARF6 PATHWAY	Arf6 signaling events
0.0	2.8	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	2.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	1.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	0.9	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.7	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 7 of 7 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	1.9	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	1.6	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.1	1.4	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.1	1.3	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	1.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	0.9	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.7	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.7	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.3	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling

Showing 1 to 10 of 10 entries

Results for DMC1

Z-value: 0.78

Motif logo

Transcription factors associated with DMC1

Activity-expression correlation:

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: