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Illumina Body Map 2
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Results for E2F3
Z-value: 1.72
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Transcription factors associated with E2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg19_v2_chr6_+_20403997_20404034 | 0.11 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_4388805 Show fit | 2.32 |
ENST00000504171.1
|
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA. |
|
| chr17_+_55334364 Show fit | 1.90 |
ENST00000322684.3
ENST00000579590.1 |
musashi RNA-binding protein 2 |
|
| chr1_+_77747656 Show fit | 1.80 |
ENST00000354567.2
|
adenylate kinase 5 |
|
| chr19_+_35773242 Show fit | 1.71 |
ENST00000222304.3
|
hepcidin antimicrobial peptide |
|
| chr19_+_35596873 Show fit | 1.70 |
ENST00000313865.6
|
Uncharacterized protein |
|
| chr3_+_54156664 Show fit | 1.56 |
ENST00000474759.1
ENST00000288197.5 |
calcium channel, voltage-dependent, alpha 2/delta subunit 3 |
|
| chr6_-_33714752 Show fit | 1.52 |
ENST00000451316.1
|
inositol hexakisphosphate kinase 3 |
|
| chr4_+_89300158 Show fit | 1.52 |
ENST00000502870.1
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr22_-_24384240 Show fit | 1.49 |
ENST00000439996.2
ENST00000417870.1 |
glutathione S-transferase theta 1 |
|
| chr7_-_16460863 Show fit | 1.47 |
ENST00000407010.2
ENST00000399310.3 |
isoprenoid synthase domain containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 6.5 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.1 | 6.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 5.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.8 | 4.2 | GO:0070352 | positive regulation of white fat cell proliferation(GO:0070352) |
| 0.1 | 4.2 | GO:0097503 | sialylation(GO:0097503) |
| 0.1 | 3.4 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.0 | 3.4 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 3.0 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.5 | 2.9 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 17.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 6.1 | GO:1902710 | GABA receptor complex(GO:1902710) |
| 0.1 | 4.7 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 4.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 4.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 4.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 4.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 4.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 4.1 | GO:0016234 | inclusion body(GO:0016234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 9.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 5.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 4.8 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 4.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 4.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 3.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 3.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.7 | 3.3 | GO:0004306 | ethanolamine-phosphate cytidylyltransferase activity(GO:0004306) |
| 0.2 | 3.2 | GO:1903136 | cuprous ion binding(GO:1903136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 5.0 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 3.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 2.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 1.8 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 7.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 7.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 5.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 5.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 4.9 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 3.8 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 3.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 3.6 | REACTOME PI3K AKT ACTIVATION | Genes involved in PI3K/AKT activation |
| 0.0 | 3.5 | REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |