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Illumina Body Map 2
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Results for E2F7_E2F1
Z-value: 1.58
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.34 | 6.0e-02 | Click! |
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.18 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0051225 | spindle assembly(GO:0051225) |
| 1.9 | 5.7 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 0.1 | 4.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 4.0 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.1 | 3.8 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 3.8 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.3 | 3.7 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 1.0 | 3.1 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.8 | 3.1 | GO:0090095 | regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.0 | 3.1 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 12.7 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 7.7 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 5.8 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 5.7 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 5.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 5.0 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 4.9 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 4.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 4.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 9.4 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 7.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 6.8 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.7 | 6.1 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.3 | 5.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 4.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 4.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 4.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 4.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 12.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 7.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 4.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 4.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 4.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 3.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 3.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.7 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.1 | 9.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 6.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 5.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 5.6 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.1 | 4.6 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 4.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 4.1 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 4.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 3.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |