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Illumina Body Map 2
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Results for EGR1_EGR4
Z-value: 0.86
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Transcription factors associated with EGR1_EGR4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR4 | hg19_v2_chr2_-_73520667_73520833 | -0.15 | 4.2e-01 | Click! |
| EGR1 | hg19_v2_chr5_+_137801160_137801179 | 0.06 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_109087906 Show fit | 2.69 |
ENST00000515500.1
|
lymphoid enhancer-binding factor 1 |
|
| chr6_+_15249128 Show fit | 2.68 |
ENST00000397311.3
|
jumonji, AT rich interactive domain 2 |
|
| chr11_-_64511789 Show fit | 2.66 |
ENST00000419843.1
ENST00000394430.1 |
RAS guanyl releasing protein 2 (calcium and DAG-regulated) |
|
| chr6_+_12012536 Show fit | 2.54 |
ENST00000379388.2
|
human immunodeficiency virus type I enhancer binding protein 1 |
|
| chr11_-_46142948 Show fit | 2.44 |
ENST00000257821.4
|
PHD finger protein 21A |
|
| chr15_+_74833518 Show fit | 2.31 |
ENST00000346246.5
|
AT rich interactive domain 3B (BRIGHT-like) |
|
| chr1_+_43148625 Show fit | 2.28 |
ENST00000436427.1
|
Y box binding protein 1 |
|
| chr19_-_33793430 Show fit | 2.19 |
ENST00000498907.2
|
CCAAT/enhancer binding protein (C/EBP), alpha |
|
| chr4_-_109087872 Show fit | 2.16 |
ENST00000510624.1
|
lymphoid enhancer-binding factor 1 |
|
| chr19_-_14201776 Show fit | 2.02 |
ENST00000269724.5
|
sterile alpha motif domain containing 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR1_EGR4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 1.3 | 5.1 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.0 | 5.0 | GO:0051983 | regulation of chromosome segregation(GO:0051983) |
| 0.7 | 4.8 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.3 | 4.8 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 4.3 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.2 | 3.9 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.0 | 3.9 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.1 | 3.2 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 3.2 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.0 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 12.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 8.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 6.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 5.9 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 5.8 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.4 | 5.4 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 4.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 3.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 3.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.0 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 7.1 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 5.7 | GO:0001012 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.3 | 5.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 5.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 1.3 | 5.1 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.1 | 5.0 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.3 | 4.8 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.1 | 4.8 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 4.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.7 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 12.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 8.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 6.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 6.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 6.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 5.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 5.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 4.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 3.6 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 7.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 5.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 4.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 4.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 3.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 3.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 3.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 3.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 3.4 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |