ISMARA results: EGR3

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Illumina Body Map 2

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Results for EGR3_EGR2

Z-value: 1.06

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Transcription factors associated with EGR3_EGR2

Gene Symbol	Gene ID	Gene Info
EGR3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000179388.8	early growth response 3
EGR2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000122877.9	early growth response 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EGR3	hg19_v2_chr8_-_22550815_22550844	0.60	2.7e-04	Click!
EGR2	hg19_v2_chr10_-_64576105_64576133	0.12	5.1e-01	Click!

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_84115868 Show fit	5.27	ENST00000427482.2	SH3GL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 3
chr11_+_124609823 Show fit	3.97	ENST00000412681.2	NRGN Ensembl NCBI GeneCards UniProt NextProt Show fit	neurogranin (protein kinase C substrate, RC3)
chr11_+_124609742 Show fit	3.90	ENST00000284292.6	NRGN Ensembl NCBI GeneCards UniProt NextProt Show fit	neurogranin (protein kinase C substrate, RC3)
chrX_+_117957741 Show fit	3.51	ENST00000310164.2	ZCCHC12 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger, CCHC domain containing 12
chr15_+_84116106 Show fit	3.43	ENST00000535412.1 ENST00000324537.5	SH3GL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 3
chr19_+_10400615 Show fit	3.15	ENST00000221980.4	ICAM5 Ensembl NCBI GeneCards UniProt NextProt Show fit	intercellular adhesion molecule 5, telencephalin
chr16_+_25703274 Show fit	3.07	ENST00000331351.5	HS3ST4 Ensembl NCBI GeneCards UniProt NextProt Show fit	heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr11_-_18813110 Show fit	2.86	ENST00000396168.1	PTPN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr19_+_49617581 Show fit	2.71	ENST00000391864.3	LIN7B Ensembl NCBI GeneCards UniProt NextProt Show fit	lin-7 homolog B (C. elegans)
chr4_-_90758227 Show fit	2.63	ENST00000506691.1 ENST00000394986.1 ENST00000506244.1 ENST00000394989.2 ENST00000394991.3	SNCA Ensembl NCBI GeneCards UniProt NextProt Show fit	synuclein, alpha (non A4 component of amyloid precursor)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	11.0	GO:1900273	positive regulation of long-term synaptic potentiation(GO:1900273)
0.7	10.0	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1	7.7	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	7.3	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	6.7	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.5	5.9	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.4	5.9	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.1	5.5	GO:0086010	membrane depolarization during action potential(GO:0086010)
0.6	5.1	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.3	5.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)

Showing 1 to 10 of 305 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.1	GO:0043195	terminal bouton(GO:0043195)
0.1	11.2	GO:0031901	early endosome membrane(GO:0031901)
0.5	9.5	GO:0031209	SCAR complex(GO:0031209)
0.1	9.2	GO:0034705	potassium channel complex(GO:0034705)
0.0	9.1	GO:0060076	excitatory synapse(GO:0060076)
0.1	8.2	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	8.2	GO:0043204	perikaryon(GO:0043204)
0.5	7.9	GO:0044327	dendritic spine head(GO:0044327)
0.4	6.1	GO:0043083	synaptic cleft(GO:0043083)
0.2	5.5	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Showing 1 to 10 of 139 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.4	GO:0048365	Rac GTPase binding(GO:0048365)
0.3	8.2	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.2	8.2	GO:0070300	phosphatidic acid binding(GO:0070300)
0.1	7.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	6.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	6.0	GO:0003785	actin monomer binding(GO:0003785)
1.2	5.9	GO:0031751	D4 dopamine receptor binding(GO:0031751)
0.4	5.1	GO:0097016	L27 domain binding(GO:0097016)
0.0	5.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.0	4.9	GO:0060961	phospholipase D inhibitor activity(GO:0060961)

Showing 1 to 10 of 222 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	10.1	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	3.9	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	3.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	3.2	PID AURORA A PATHWAY	Aurora A signaling
0.0	2.8	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	2.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	2.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	2.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	2.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	18.7	REACTOME NEURONAL SYSTEM	Genes involved in Neuronal System
0.1	9.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.4	9.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	6.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	6.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	6.0	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	5.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	4.4	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	4.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	4.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway

Showing 1 to 10 of 58 entries

Results for EGR3_EGR2

Z-value: 1.06

Motif logo

Transcription factors associated with EGR3_EGR2

Activity-expression correlation:

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: