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Illumina Body Map 2
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Results for ELF2_GABPA_ELF5
Z-value: 3.87
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Transcription factors associated with ELF2_GABPA_ELF5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000109381.15 | E74 like ETS transcription factor 2 | |
| ENSG00000154727.6 | GA binding protein transcription factor subunit alpha | |
| ENSG00000135374.5 | E74 like ETS transcription factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF5 | hg19_v2_chr11_-_34535297_34535317 | -0.41 | 1.8e-02 | Click! |
| GABPA | hg19_v2_chr21_+_27107672_27107698 | 0.36 | 4.0e-02 | Click! |
| ELF2 | hg19_v2_chr4_-_140005443_140005650 | 0.16 | 3.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 479.3 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.7 | 270.4 | GO:0050851 | antigen receptor-mediated signaling pathway(GO:0050851) |
| 1.3 | 188.9 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.0 | 71.2 | GO:0006968 | cellular defense response(GO:0006968) |
| 6.8 | 47.7 | GO:0098759 | response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) |
| 0.4 | 42.8 | GO:0006413 | translational initiation(GO:0006413) |
| 0.4 | 42.5 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.7 | 42.1 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.4 | 41.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.6 | 39.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 315.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 236.3 | GO:0005829 | cytosol(GO:0005829) |
| 0.3 | 155.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.2 | 147.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 133.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.1 | 124.3 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.9 | 121.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.6 | 109.2 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 1.2 | 103.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 89.9 | GO:0005634 | nucleus(GO:0005634) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 137.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 127.4 | GO:0003677 | DNA binding(GO:0003677) |
| 0.2 | 124.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 74.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.8 | 70.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 69.9 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.2 | 69.9 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.0 | 62.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.2 | 57.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.6 | 56.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 208.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.9 | 84.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.2 | 80.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.2 | 78.7 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.5 | 64.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.4 | 52.6 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.7 | 51.5 | PID ATM PATHWAY | ATM pathway |
| 0.5 | 50.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.3 | 47.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.9 | 46.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 227.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.4 | 169.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.5 | 105.2 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 2.9 | 96.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.3 | 90.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.1 | 81.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.0 | 78.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.7 | 63.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 1.6 | 54.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 52.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |