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Illumina Body Map 2
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Results for EMX1
Z-value: 1.59
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Transcription factors associated with EMX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EMX1 | hg19_v2_chr2_+_73144604_73144654 | 0.44 | 1.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_111794446 Show fit | 9.64 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chr1_+_160160283 Show fit | 7.43 |
ENST00000368079.3
|
calsequestrin 1 (fast-twitch, skeletal muscle) |
|
| chr1_+_160160346 Show fit | 7.08 |
ENST00000368078.3
|
calsequestrin 1 (fast-twitch, skeletal muscle) |
|
| chr13_+_110958124 Show fit | 6.15 |
ENST00000400163.2
|
collagen, type IV, alpha 2 |
|
| chr9_-_95166976 Show fit | 5.76 |
ENST00000447356.1
|
osteoglycin |
|
| chr12_-_6233828 Show fit | 5.58 |
ENST00000572068.1
ENST00000261405.5 |
von Willebrand factor |
|
| chr13_-_38172863 Show fit | 5.44 |
ENST00000541481.1
ENST00000379743.4 ENST00000379742.4 ENST00000379749.4 ENST00000541179.1 ENST00000379747.4 |
periostin, osteoblast specific factor |
|
| chr2_-_217560248 Show fit | 5.21 |
ENST00000233813.4
|
insulin-like growth factor binding protein 5 |
|
| chr9_+_134165063 Show fit | 4.95 |
ENST00000372264.3
|
phosphatidic acid phosphatase type 2 domain containing 3 |
|
| chr15_+_62853562 Show fit | 4.83 |
ENST00000561311.1
|
talin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EMX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.1 | 14.5 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.6 | 13.1 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 11.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 10.1 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 10.1 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.4 | 9.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.2 | 8.9 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 8.8 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.2 | 6.1 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 27.7 | GO:0030018 | Z disc(GO:0030018) |
| 1.8 | 14.5 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 13.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 13.2 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 10.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.6 | 9.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 8.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 8.3 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 7.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 12.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 12.5 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 12.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 11.6 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 11.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 10.1 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 10.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 9.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 8.4 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.5 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.3 | 20.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 9.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 6.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 5.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 4.7 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 3.9 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 3.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 3.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 10.8 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 10.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 9.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 7.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 5.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 5.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 5.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 5.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.9 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |