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Illumina Body Map 2
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Results for EN1_ESX1_GBX1
Z-value: 1.12
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Transcription factors associated with EN1_ESX1_GBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESX1 | hg19_v2_chrX_-_103499602_103499617 | 0.23 | 2.1e-01 | Click! |
| GBX1 | hg19_v2_chr7_-_150864635_150864785 | 0.19 | 2.9e-01 | Click! |
| EN1 | hg19_v2_chr2_-_119605253_119605264 | 0.03 | 8.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_160160346 Show fit | 4.91 |
ENST00000368078.3
|
calsequestrin 1 (fast-twitch, skeletal muscle) |
|
| chr1_+_160160283 Show fit | 4.90 |
ENST00000368079.3
|
calsequestrin 1 (fast-twitch, skeletal muscle) |
|
| chr4_-_138453606 Show fit | 4.35 |
ENST00000412923.2
ENST00000344876.4 ENST00000507846.1 ENST00000510305.1 |
protocadherin 18 |
|
| chr9_-_95166976 Show fit | 3.79 |
ENST00000447356.1
|
osteoglycin |
|
| chr3_+_115342349 Show fit | 3.57 |
ENST00000393780.3
|
growth associated protein 43 |
|
| chr9_-_95166884 Show fit | 3.54 |
ENST00000375561.5
|
osteoglycin |
|
| chr15_-_37393406 Show fit | 3.51 |
ENST00000338564.5
ENST00000558313.1 ENST00000340545.5 |
Meis homeobox 2 |
|
| chr10_-_93392811 Show fit | 3.24 |
ENST00000238994.5
|
protein phosphatase 1, regulatory subunit 3C |
|
| chr1_-_234667504 Show fit | 3.19 |
ENST00000421207.1
ENST00000435574.1 |
RP5-855F14.1 |
|
| chr13_-_36788718 Show fit | 3.02 |
ENST00000317764.6
ENST00000379881.3 |
spermatogenesis and oogenesis specific basic helix-loop-helix 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EN1_ESX1_GBX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.4 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.4 | 10.3 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 8.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.6 | 8.3 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 7.5 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 5.4 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.2 | 5.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 1.7 | 5.2 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 0.3 | 5.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 1.5 | 4.4 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.2 | 9.8 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 9.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 8.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 8.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 6.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 5.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 5.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 4.6 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 4.3 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 9.0 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 8.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 7.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 5.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.3 | 5.2 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.0 | 5.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 4.7 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.2 | 4.2 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.1 | 4.2 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 9.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 6.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 4.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 4.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.3 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 7.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 6.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.4 | 5.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 4.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 4.1 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 3.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |