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Illumina Body Map 2
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Results for EN2_GBX2_LBX2
Z-value: 0.71
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Transcription factors associated with EN2_GBX2_LBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LBX2 | hg19_v2_chr2_-_74730087_74730111 | -0.23 | 2.1e-01 | Click! |
| EN2 | hg19_v2_chr7_+_155250824_155250824 | -0.18 | 3.2e-01 | Click! |
| GBX2 | hg19_v2_chr2_-_237076992_237077012 | -0.12 | 5.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_36245561 Show fit | 5.31 |
ENST00000506189.1
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
|
| chr17_-_76732928 Show fit | 2.15 |
ENST00000589768.1
|
cytohesin 1 |
|
| chrX_-_21676442 Show fit | 2.07 |
ENST00000379499.2
|
kelch-like family member 34 |
|
| chr15_+_58430368 Show fit | 1.92 |
ENST00000558772.1
ENST00000219919.4 |
aquaporin 9 |
|
| chr15_+_58430567 Show fit | 1.80 |
ENST00000536493.1
|
aquaporin 9 |
|
| chr7_+_77428066 Show fit | 1.78 |
ENST00000422959.2
ENST00000307305.8 ENST00000424760.1 |
putative homeodomain transcription factor 2 |
|
| chr7_+_77428149 Show fit | 1.67 |
ENST00000415251.2
ENST00000275575.7 |
putative homeodomain transcription factor 2 |
|
| chr18_+_59000815 Show fit | 1.47 |
ENST00000262717.4
|
cadherin 20, type 2 |
|
| chr12_+_81110684 Show fit | 1.43 |
ENST00000228644.3
|
myogenic factor 5 |
|
| chr7_-_77427676 Show fit | 1.31 |
ENST00000257663.3
|
transmembrane protein 60 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EN2_GBX2_LBX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.7 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.4 | 2.2 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 0.3 | 2.2 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.1 | 2.0 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 1.7 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.0 | 1.6 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.1 | 1.4 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.2 | 1.3 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.0 | 1.2 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.2 | 1.1 | GO:0061055 | myotome development(GO:0061055) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 2.6 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 2.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 1.7 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 1.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 1.3 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.0 | 1.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 0.5 | GO:0071547 | piP-body(GO:0071547) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.7 | 3.7 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 2.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 2.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 2.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.7 | 2.0 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.1 | 2.0 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 1.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.4 | 1.2 | GO:0005174 | CD40 receptor binding(GO:0005174) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 2.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.6 | PID REELIN PATHWAY | Reelin signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 3.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.4 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 2.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 2.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.4 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |