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Illumina Body Map 2
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Results for EOMES
Z-value: 0.91
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Transcription factors associated with EOMES
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EOMES | hg19_v2_chr3_-_27764190_27764208 | -0.32 | 7.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_139613269 Show fit | 3.03 |
ENST00000358430.3
|
taxilin beta |
|
| chr16_+_30064444 Show fit | 2.17 |
ENST00000395248.1
ENST00000566897.1 ENST00000568435.1 |
aldolase A, fructose-bisphosphate |
|
| chr16_+_30064411 Show fit | 1.84 |
ENST00000338110.5
|
aldolase A, fructose-bisphosphate |
|
| chrY_+_15016725 Show fit | 1.57 |
ENST00000336079.3
|
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
|
| chr10_-_101190202 Show fit | 1.48 |
ENST00000543866.1
ENST00000370508.5 |
glutamic-oxaloacetic transaminase 1, soluble |
|
| chr3_-_42744130 Show fit | 1.42 |
ENST00000417472.1
ENST00000442469.1 |
hedgehog acyltransferase-like |
|
| chr10_-_13342051 Show fit | 1.35 |
ENST00000479604.1
|
phytanoyl-CoA 2-hydroxylase |
|
| chrY_+_15016013 Show fit | 1.30 |
ENST00000360160.4
ENST00000454054.1 |
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
|
| chr1_-_184943610 Show fit | 1.25 |
ENST00000367511.3
|
family with sequence similarity 129, member A |
|
| chr10_-_13342097 Show fit | 1.20 |
ENST00000263038.4
|
phytanoyl-CoA 2-hydroxylase |
Network of associatons between targets according to the STRING database.
First level regulatory network of EOMES
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.0 | 3.7 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 3.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 3.1 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 3.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.5 | 2.5 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.0 | 2.2 | GO:1901998 | toxin transport(GO:1901998) |
| 0.2 | 1.8 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.2 | 1.7 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
| 0.1 | 1.7 | GO:1901725 | regulation of histone deacetylase activity(GO:1901725) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 3.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 3.2 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 2.5 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 1.8 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 1.7 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.1 | 1.7 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 1.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 1.6 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 3.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 3.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 2.9 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.1 | 2.6 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.8 | 2.5 | GO:0048244 | phytanoyl-CoA dioxygenase activity(GO:0048244) |
| 0.2 | 2.2 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.1 | 2.2 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 1.8 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.2 | 1.7 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 3.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.0 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 3.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.5 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 2.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 1.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 1.7 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 1.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.6 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 1.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |