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Illumina Body Map 2
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Results for ERG
Z-value: 3.39
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Transcription factors associated with ERG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ERG | hg19_v2_chr21_-_40032581_40032605 | 0.07 | 7.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ERG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 178.2 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.6 | 98.1 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.4 | 73.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.7 | 58.0 | GO:0006968 | cellular defense response(GO:0006968) |
| 2.7 | 51.7 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 2.2 | 48.1 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 2.0 | 40.9 | GO:0045086 | positive regulation of interleukin-2 biosynthetic process(GO:0045086) |
| 0.5 | 40.7 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.3 | 36.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 36.7 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 124.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.4 | 119.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.4 | 85.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.7 | 80.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 77.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.6 | 67.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 67.7 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 62.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 51.7 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.4 | 51.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 131.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 84.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 55.8 | GO:0019001 | guanyl nucleotide binding(GO:0019001) |
| 0.5 | 54.9 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 48.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 48.3 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 3.9 | 46.3 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.6 | 46.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 1.5 | 44.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 34.5 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 190.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.2 | 84.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 67.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.6 | 56.5 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.1 | 50.1 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.8 | 48.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 46.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 42.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.8 | 40.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.8 | 28.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 182.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 3.0 | 97.6 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.3 | 80.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 68.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.8 | 61.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.8 | 59.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.8 | 54.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.1 | 41.4 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.4 | 39.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 30.5 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |