ISMARA results: ESRRA

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Illumina Body Map 2

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Results for ESRRA_ESR2

Z-value: 2.83

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Transcription factors associated with ESRRA_ESR2

Gene Symbol	Gene ID	Gene Info
ESRRA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000173153.9	estrogen related receptor alpha
ESR2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000140009.14	estrogen receptor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ESR2	hg19_v2_chr14_-_64804814_64804842	-0.28	1.2e-01	Click!
ESRRA	hg19_v2_chr11_+_64073022_64073056	0.24	1.9e-01	Click!

Activity profile of ESRRA_ESR2 motif

Sorted Z-values of ESRRA_ESR2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_106174960 Show fit	10.28	ENST00000390547.2	IGHA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant alpha 1
chr1_-_173886491 Show fit	9.71	ENST00000367698.3	SERPINC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade C (antithrombin), member 1
chr10_-_54531406 Show fit	7.76	ENST00000373968.3	MBL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	mannose-binding lectin (protein C) 2, soluble
chr22_+_22676808 Show fit	7.64	ENST00000390290.2	IGLV1-51 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 1-51
chr9_-_116840728 Show fit	7.44	ENST00000265132.3	AMBP Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-1-microglobulin/bikunin precursor
chr22_+_23248512 Show fit	7.01	ENST00000390325.2	IGLC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 3 (Kern-Oz+ marker)
chr14_-_106322288 Show fit	6.92	ENST00000390559.2	IGHM Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant mu
chr22_+_23237555 Show fit	6.83	ENST00000390321.2	IGLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 1 (Mcg marker)
chr14_-_106054659 Show fit	6.76	ENST00000390539.2	IGHA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant alpha 2 (A2m marker)
chr17_-_7082861 Show fit	6.58	ENST00000269299.3	ASGR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	asialoglycoprotein receptor 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ESRRA_ESR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	105.8	GO:0006910	phagocytosis, recognition(GO:0006910)
0.9	95.7	GO:0006958	complement activation, classical pathway(GO:0006958)
0.5	88.8	GO:0002377	immunoglobulin production(GO:0002377)
0.3	86.2	GO:0002250	adaptive immune response(GO:0002250)
0.1	76.6	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.6	36.3	GO:0006953	acute-phase response(GO:0006953)
0.4	35.6	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.9	32.1	GO:2000257	regulation of protein activation cascade(GO:2000257)
0.4	26.8	GO:0030212	hyaluronan metabolic process(GO:0030212)
2.2	24.4	GO:0060267	positive regulation of respiratory burst(GO:0060267)

Showing 1 to 10 of 1,372 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	105.9	GO:0072562	blood microparticle(GO:0072562)
2.0	103.6	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	44.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	42.5	GO:0035579	specific granule membrane(GO:0035579)
0.4	40.4	GO:0035580	specific granule lumen(GO:0035580)
0.4	40.0	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.3	36.9	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	35.3	GO:0005759	mitochondrial matrix(GO:0005759)
0.5	33.7	GO:0001772	immunological synapse(GO:0001772)
0.2	29.2	GO:0016605	PML body(GO:0016605)

Showing 1 to 10 of 429 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	200.5	GO:0003823	antigen binding(GO:0003823)
1.9	123.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.3	54.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	44.0	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	34.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	25.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.2	21.8	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.6	21.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4	19.2	GO:0042056	chemoattractant activity(GO:0042056)
2.0	17.9	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)

Showing 1 to 10 of 865 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	63.4	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.8	58.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	42.9	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	34.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	29.5	PID ARF6 PATHWAY	Arf6 signaling events
0.4	29.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.9	27.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.3	24.8	PID IL4 2PATHWAY	IL4-mediated signaling events
0.5	23.3	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.2	21.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Showing 1 to 10 of 115 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	96.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.7	36.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
1.4	36.1	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
1.1	33.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.3	31.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.3	29.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.4	28.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.4	26.9	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.4	25.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.8	23.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade

Showing 1 to 10 of 195 entries

Results for ESRRA_ESR2

Z-value: 2.83

Motif logo

Transcription factors associated with ESRRA_ESR2

Activity-expression correlation:

Activity profile of ESRRA_ESR2 motif

Sorted Z-values of ESRRA_ESR2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ESRRA_ESR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: